Frequency of Chronic Kidney Disease (CKD) in Diabetic Cancer Patients

Authors

  • Mishal Awan Department of Internal Medicine, Shaukat Khanum Memorial Hospital, Lahore, Punjab, Pakistan.
  • Muhammad Arslan Department of Internal Medicine, Mujahid Hospital, Lahore, Punjab, Pakistan.

DOI:

https://doi.org/10.70749/ijbr.v3i4.1172

Keywords:

Cancer, Diabetes Mellitus, Chronic Kidney Disease

Abstract

Objective: To determine the frequency of chronic kidney disease in diabetes mellitus associated cancer patients. Design of Study: Cross-sectional study. Place and Study Duration: Department of Medicine, Shaukat Khanum Memorial Hospital and Research centre, Lahore. From January 2024 to December 2024. Methodology: A total of 96 individuals, both male and female, aged 18 to 60, with diabetes and cancer were included. Cases involving known non diabetic patients and patients with type 1 diabetes were excluded. The fundamental variables include age (in years), gender, and the type of cancer were noted down via a patient information sheet. Diabetes, hypertension, glomerulonephritis, or genetic predisposition are some of the underlying factors that can lead to impaired waste and fluid regulation in the body. Kidney damage indicators such as albuminuria and a persistent decline in GFR below 60 mL/min/1.73 m² are indicators of CKD, which is characterized by a progressive loss of kidney function. Results: The study's participants ranged in age from 18 to 60, with a mean age of 47.30 ± 8.64 years.  The majority of the 71 patients, or 73.96%, were in the 41–60 age range.  With a male to female ratio of 1.7:1, 61 (63.54%) of the 96 patients were men and 35 (36.46%) were women.  In our investigation, the average duration of DM was 5.86 ± 2.65 years. 37 (38.54%) of the cancer patients in our study who had diabetes mellitus also had chronic renal disease.  Conclusion: According to the study's findings, cancer patients with diabetes mellitus have a very high prevalence of chronic renal disease.

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References

Pastor, S. (2020). Genetic variants associated with chronic kidney disease in a Spanish population. Scientific Reports, 10(1), 1-11. https://doi.org/10.1038/s41598-019-56695-2

Ma, R. C. W. (2018). Epidemiology of diabetes and diabetic complications in China. Diabetologia, 61(6), 1249–1260. https://doi.org/10.1007/s00125-018-4557-7

Levey, A. S., Stevens, L. A., Schmid, C. H., Zhang, Y. (., Castro, A. F., Feldman, H. I., Kusek, J. W., Eggers, P., Van Lente, F., Greene, T., & Coresh, J. (2009). A new equation to estimate glomerular filtration rate. Annals of Internal Medicine, 150(9), 604-612. https://doi.org/10.7326/0003-4819-150-9-200905050-00006

Coresh, J., Selvin, E., Stevens, L. A., Manzi, J., Kusek, J. W., Eggers, P., Van Lente, F., & Levey, A. S. (2007). Prevalence of chronic kidney disease in the United States. JAMA, 298(17), 2038. https://doi.org/10.1001/jama.298.17.2038

Wyld, M. L., Mata, N. L., Viecelli, A., Swaminathan, R., O'Sullivan, K. M., O'Lone, E., Rowlandson, M., Francis, A., Wyburn, K., & Webster, A. C. (2022). Sex-based differences in risk factors and complications of chronic kidney disease. Seminars in Nephrology, 42(2), 153-169. https://doi.org/10.1016/j.semnephrol.2022.04.006

Cengiz, K. (2002). Increased incidence of neoplasia in chronic renal failure (20-year experience). International Urology and Nephrology, 33(1), 121–126. https://doi.org/10.1023/a:1014489911153

Vajdic, C. M., McDonald, S. P., McCredie, M. R. E., van Leeuwen, M. T., Stewart, J. H., Law, M., Chapman, J. R., Webster, A. C., Kaldor, J. M., & Grulich, A. E. (2006). Cancer Incidence Before and After Kidney Transplantation. JAMA, 296(23), 2823. https://doi.org/10.1001/jama.296.23.2823

Malyszko, J., Tesarova, P., Capasso, G., & Capasso, A. (2020). The link between kidney disease and cancer: Complications and treatment. The Lancet, 396(10246), 277-287. https://doi.org/10.1016/s0140-6736(20)30540-7

Fiseha, T., & Tamir, Z. (2020). Prevalence and awareness of chronic kidney disease among adult diabetic outpatients in Northeast Ethiopia. BMC Nephrology, 21(1). https://doi.org/10.1186/s12882-020-01768-y

Jitraknatee, J., Ruengorn, C., & Nochaiwong, S. (2020). Prevalence and risk factors of chronic kidney disease among type 2 diabetes patients: A cross-sectional study in primary care practice. Scientific Reports, 10(1). https://doi.org/10.1038/s41598-020-63443-4

Abd ElHafeez, S., Bolignano, D., D’Arrigo, G., Dounousi, E., Tripepi, G., & Zoccali, C. (2018). Prevalence and burden of chronic kidney disease among the general population and high-risk groups in Africa: A systematic review. BMJ Open, 8(1), e015069. https://doi.org/10.1136/bmjopen-2016-015069

Naser, A. Y., Alwafi, H., Alotaibi, B., Salawati, E., Samannodi, M., Alsairafi, Z., Alanazi, A. F., & Dairi, M. S. (2021). Prevalence of chronic kidney diseases in patients with diabetes mellitus in the Middle East: A systematic review and meta-analysis. International Journal of Endocrinology, 2021, 1-9. https://doi.org/10.1155/2021/4572743

Tesfe, D., Adugna, M., Nigussie, Z. M., Woldeyohanins, A. E., & Kifle, Z. D. (2022). The proportion of chronic kidney disease and its associated factors among adult diabetic patients at Tibebe Ghion specialized hospital, Bahir DAR, Ethiopia. Metabolism Open, 15, 100198. https://doi.org/10.1016/j.metop.2022.100198

Alemu, H., Hailu, W., & Adane, A. (2020). Prevalence of chronic kidney disease and associated factors among patients with diabetes in northwest Ethiopia: A hospital-based cross-sectional study. Current Therapeutic Research, 92, 100578. https://doi.org/10.1016/j.curtheres.2020.100578

Israel, E., Borko, U. D., Mota, K., Tesfaw, M., Feleke, T., Abraham, A., Akako, B., Samuel, B., & Aynalem, A. (2024). Out of sight: Chronic kidney diseases among diabetic patients attending care and follow up. Findings from pastoralist health facilities of Southern Ethiopia. Frontiers in Public Health, 12. https://doi.org/10.3389/fpubh.2024.1326011

Fiseha, T. (2014). Prevalence of chronic kidney disease and associated risk factors among diabetic patients in Southern Ethiopia. American Journal of Health Research, 2(4), 216. https://doi.org/10.11648/j.ajhr.20140204.28

Akpor, O. A., Adeoye, A. O., Ibitoba, F. A., & Akpor, O. B. (2022). Prevalence of chronic kidney disease among diabetes and hypertensive patients in a teaching hospital in Ekiti state, Southwest Nigeria. The Open Public Health Journal, 15(1). https://doi.org/10.2174/18749445-v15-e221220-2022-99

Afkarian, M., Zelnick, L. R., Hall, Y. N., Heagerty, P. J., Tuttle, K., Weiss, N. S., & De Boer, I. H. (2016). Clinical manifestations of kidney disease among US adults with diabetes, 1988-2014. JAMA, 316(6), 602. https://doi.org/10.1001/jama.2016.10924

Zhou, Y., Echouffo-Tcheugui, J. B., Gu, J., Ruan, X., Zhao, G., Xu, W., Yang, L., Zhang, H., Qiu, H., Narayan, K. M., & Sun, Q. (2013). Prevalence of chronic kidney disease across levels of glycemia among adults in Pudong new area, Shanghai, China. BMC Nephrology, 14(1). https://doi.org/10.1186/1471-2369-14-253

Low, S. K., Sum, C. F., Yeoh, L. Y., Tavintharan, S., Ng, X. W., Lee, S. B., Tang, W. E., & Lim, S. C. (2015). Prevalence of chronic kidney disease in adults with type 2 diabetes mellitus. Annals of the Academy of Medicine, Singapore, 44(5), 164-171. https://doi.org/10.47102/annals-acadmedsg.v44n5p164

Rossing, P., Caramori, M., Chan, J., & Al., E. (2023). Executive summary of the KDIGO 2022 clinical practice guideline for diabetes management in chronic kidney disease: An update based on rapidly emerging new evidence. KIDNEYS, 11(4), 218-230. https://doi.org/10.22141/2307-1257.11.4.2022.386

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Published

2025-04-30

How to Cite

Frequency of Chronic Kidney Disease (CKD) in Diabetic Cancer Patients. (2025). Indus Journal of Bioscience Research, 3(4), 800-804. https://doi.org/10.70749/ijbr.v3i4.1172