Examine the Factors Influencing the Occurrence of Molar Pregnancies Among Women Attending in Tertiary Care PMC Hospital, Nawabshah
DOI:
https://doi.org/10.70749/ijbr.v3i7.2588Keywords:
Molar pregnancy, parity, cousin marriageAbstract
Introduction: Hydatidiform mole problems, particularly the emergence of invasive forms, may have a significant impact on women's health in underdeveloped areas. The clinical and epidemiological research suggests that HM is a public health concern. The prevalence of molar pregnancy has been recorded in a variety of target populations and geographical locations. One out of every 45 live births was reported to have GTD in a Sindhi tertiary hospital. Objectives: To determine the frequency of factors leading to hydatidiform mole among pregnant women. Study design: Descriptive, cross-sectional study. Setting: People's University of Medical and Health Sciences for Women, Shaheed Benazirabad, Sindh. Duration of study: January 2025 to June 2025. Materials & Methods: One hundred women with HM between the ages of 18 and 45 were enrolled. Patients who had hypertension or any other type of cancer in any part of their body were not included. We collected their demographic information, such as age, length of time since marriage, and history of using oral contraceptive pills (OCPs). They had their risk factors evaluated. Results: The study's participants ranged in age from 18 to 45, with a mean age of 29.50 ± 5.71 years. Of the 57 patients, the majority (57.0%) were in the 18–30 age range. Age >40 years (5.0%), parity >2 (22.0%), history of prior mole (5.0%), and cousin marriage (23.0%), according to my research, are the factors that contribute to hydatidiform moles in pregnant women. Conclusion: Age >40 years (5.0%), parity >2 (22.0%), history of prior mole (5.0%), and cousin marriage (23.0%) are characteristics that contribute to hydatidiform mole in pregnant women, according to the study's findings.
Downloads
References
1. Ireson J, Jones G, Winter MC, Radley SC, Hancock BW, Tidy JA. Systematic review of health-related quality of life and patient-reported outcome measures in gestational trophoblastic disease: a parallel synthesis approach. Lancet Oncol. 2018;19(1):e56-e64.
https://doi.org/10.1016/s1470-2045(17)30686-1
2. Jiang F, Wan XR, Xu T, Feng FZ, Ren T, Yang JJ, et al. Evaluation and suggestions for improving the FIGO 2000 staging criteria for gestational trophoblastic neoplasia: A ten-year review of 1420 patients. Gynecol Oncol. 2018;149(3):539-44.
https://doi.org/10.1016/j.ygyno.2018.04.001
3. Tarney CM, Tian C, Craig ER, Crothers BA, Chan JK, Gist GD, et al. Relative effects of age, race, and stage on mortality in gestational choriocarcinoma. Int J Gynecol Cancer. 2018;28(2):338-45.
https://doi.org/10.1097/igc.0000000000001156
4. Zong L, Yang J, Wang X, Kong Y, Ren T, Zhao J, et al. Management and prognosis of patients with liver metastases from gestational trophoblastic neoplasia: a retrospective cohort study. Cancer Manag Res. 2018;10:557-63.
https://doi.org/10.2147/cmar.s160606
5. Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, et al. Update on the diagnosis and management of gestational trophoblastic disease. Int J Gynaecol Obstet. 2018;143 Suppl 2:79-85.
https://doi.org/10.1002/ijgo.12615
6. Bangash AG, Sadaf R. Gestational trophoblast neoplasia and mortality risk factors. J Med Sci 2017;25(1):19-23.
7. Perveen S, Jabbar S, Nizar S. Gestational trophoblastic disease and gestational trophoblastic neoplasm-an experience at tertiary care hospital. Ann Abbasi Shaheed Hosp Karachi Med Dent Coll 2018;23(3):136-42.
https://doi.org/10.58397/ashkmdc.v23i3.74
8. Shamshiri Milani H, Abdollahi M, Torbati S, Asbaghi T, Azargashb E. Risk factors for hydatidiform mole: Is husband's job a major risk factor? Asian Pac J Cancer Prev. 2017;18(10):2657-62.
https://doi.org/10.31557/apjcb.2017.2.1.1-2
9. Schorge JOW, Schorge JO, Bradshaw KD, Halvorson LM, Schaffer JI, Corton MM, Williams Gynecology, McGraw-Hill, New York City, NY, USA, 2008.
10. Fu J, Fang F, Xie L. Prophylactic chemotherapy for hydatidiform mole to prevent gestational trophoblastic neoplasia. Cochrane Database of Systematic Rev. 2012;11:CD007289.
https://doi.org/10.1002/14651858.cd007289.pub2
11. Lurain JR. Gestational trophoblastic disease I: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole. Am J Obstet Gynecol. 2010;203:531–39.
https://doi.org/10.1016/j.ajog.2010.06.073
12. Igwegbe A. Hydatidiform mole: a review of management outcomes in a tertiary hospital in south-east Nigeria. Ann Med Health Sci. Res. 2013;3:210.
https://doi.org/10.4103/2141-9248.113664
13. Mohammadjafari R, Abedi P. The gestational trophoblastic diseases: a ten year retrospective study. Cell Journal, 2010;4.
14. Bugti QA, Baloch N, Baloch MA. Gestational trophoblastic disease in Quetta. Pak J Med Res. 2005;44:92–95.
15. Genest DR. Partial hydatiform mole: Clinicopathological features differential diagnosis ploidy and molecular studies and gold standards for diagnosis. Int J Ginecol Pathol 2001;20(4):355-22.
https://doi.org/10.1097/00004347-200110000-00001
16. Grgurević M. Trofoblastna bolest. U: Dražančić A i sur. Porodništvo. Školska knjiga Zagreb. 1994;242-248.
17. Sebire NJ, Foskett M, Fisher RA, Ress CH, Seckl M, Newlands E. Risk of partial and complete hydatiform molar pregnancy in relation to maternal age. BJOG 2002;109:99-102.
https://doi.org/10.1111/j.1471-0528.2002.t01-1-01037.x
18. Berkowitz RS, Goldstein DP. Gestational trophoblastic disease. In: Berek JS. Novaks Gynecology. Lippincott Philadelphia. 2003; pp1353-1374.
19. Haller H. Gestacijska trofoblastična bolest. In: Kuvačić I, Kurjak A, Đelmiš J et al. Porodništvo. Medicinska naklada Zagreb, 2009;257-259.
20. Harriet O.S. Gestational trophoblastic disease, epidemiology and tends. Clin Obstet Gynecol. 2003;46:541-5.
https://doi.org/10.1097/00003081-200309000-00006
21. Berkowitz RS, Goldstein DP. Gestational trophoblastic disease. In: Berek JS. Novaks Gynecology. Lippincott Philadelphia. 2003; pp1353-1374.
22. Genest DR. Partial hydatiform mole: Clinicopathological features differential diagnosis ploidy and molecular studies and gold standards for diagnosis. Int J Ginecol Pathol 2001;20(4):355-22.
https://doi.org/10.1097/00004347-200110000-00001
23. Audu BM, Takai IU, Chama CM, Bukar M, Kyari O. Hydatidiform mole as seen in a University Teaching Hospital: A 10-year review. J Obstet Gynaecol. 2009;29(4):322-325.
https://doi.org/10.1080/01443610902807345
24. Hancock B, Tidy J. Curent management of molar pregnancy. J. Repord Med 2002;47:347-354.
25. Parazzini F, LA Vecchia S, Pampallona S. Parental age and risk of complate and partial hydatidiform mole. BJOG. 1986;93(4):582-585.
https://doi.org/10.1111/j.1471-0528.1986.tb07957.x
26. Ben Temime Riadh, Chechia A, Hannachi W, Attia L, Makhlouf T, Koubaa A. Clinical analysis and Management of gestational trophoblastic disease: A 90 cases study. International Journal of Biomedical Science. 2009;5(4):321-325.
https://doi.org/10.59566/ijbs.2009.5321
27. Altieri A, Franceschi S, Ferlay J. Epidemiology and an etiology of gestational trophoblastic disease. Lancet Oncol. 2003;4(11):670-8.
https://doi.org/10.1016/s1470-2045(03)01245-2
28. Nowak E, Drews K, Spacznski M. Gestational trophoblastic disease. 2000;71(8):767-72.
29. Kuvačić I. Spontani i habitualni pobačaji. U: Dražančić A. Porodništvo. Zagreb: Školska knjiga, 1994;218-220.
30. Semer DA, Macfee MS. Gestational trophoblastic disease epidemiology. Semin Oncol. 1995;22:109-15.
31. Kashanian M, Baradaran HR, Teimour IN. Risk factors for complete molar pregnancy: A study in Iran. J Reprod Med 2009;54(10):621-4.
32. Rezavanet N, Kamravamanesh M, Safdari Z, Ghodsi F. Study hydatidiform mole frequency and some of its relevant factors. IJAR. 2011;3(2):834-837.
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Indus Journal of Bioscience Research

This work is licensed under a Creative Commons Attribution 4.0 International License.
