Inflammation and Cardiovascular Risk: Investigating the Link between CRP and Coronary Artery Disease
DOI:
https://doi.org/10.70749/ijbr.v3i4.1054Keywords:
C-Reactive Protein, Coronary Artery Disease, Hs-CRP, Inflammation, Risk StratificationAbstract
Objective: To evaluate the association between C-reactive protein levels and the severity of coronary artery disease in a population of patients. Methodology: This was a retrospective observational study involving 220 patients, divided into two groups based on their hs-CRP levels: Group A (<3 mg/L) and Group B (≥3 mg/L). Data was collected from hospital records, including patient demographics, CRP levels, and coronary angiography results. Chi-square and T-tests were used for statistical analysis, with p < 0.05 considered significant. Results: Of the 220 patients, Group B (hs-CRP ≥3 mg/L) was significantly older (55.1 ± 9.4 years vs. 50.2 ± 11.1 years, p = 0.0004). Chi-square test showed a significant correlation between CRP levels and CAD severity (χ² = 15.21, p = 0.0016), with more patients in Group B presenting with multi-vessel disease (TVD/DVD). T-test for age comparison between CRP groups revealed a significant age difference (t = -3.59, p = 0.0004). Conclusion: Elevated CRP levels are strongly associated with increased CAD severity and older age in patients, supporting CRP as an effective inflammatory marker for predicting cardiovascular risk. These findings highlight the importance of incorporating CRP testing into routine cardiovascular screening.
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References
Amezcua-Castillo, González-Pacheco, Martín, Méndez-Ocampo, Gutiérrez-Moctezuma, Massó, et al. C-Reactive Protein: The Quintessential Marker Of Systemic Inflammation In Coronary Artery Disease—Advancing Toward Precision Medicine. Biomedicines 2023;11. https://doi.org/10.3390/biomedicines11092444
Zhao, Gao, Chen, Chen, Liu, Gu. C-Reactive Protein: An Important Inflammatory Marker Of Coronary Atherosclerotic Disease. Angiology 2024:33197241273360-. https://doi.org/10.1177/00033197241273360
Zeller, Bogner, Mcfadyen, Kiefer, Braig, Pietersz, et al. Transitional Changes In The Structure Of C-Reactive Protein Create Highly Pro-Inflammatory Molecules: Therapeutic Implications For Cardiovascular Diseases. Pharmacol Ther 2022:108165. https://doi.org/10.1016/j.pharmthera.2022.108165
Yang, Pan, Zheng. Baseline High-Sensitivity C-Reactive Protein As A Predictor Of Adverse Clinical Events In Patients With Coronary Artery Disease Undergoing Percutaneous Coronary Intervention: A Meta-Analysis. Cardiol Rev 2023. https://doi.org/10.1097/crd.0000000000000604
Shahid. Analysis Of C Reactive Protein And Other Inflammatory Markers In The Cardiovascular Risk Prediction In Women. Isra Med J 2022. https://doi.org/10.55282/imj.oa1320
Ali, Zehra, Khalid, Hassan, Shah. Role Of C-Reactive Protein In Disease Progression, Diagnosis And Management. Discoveries 2023;11. https://doi.org/10.15190/d.2023.18
Han, Fritzer-Szekeres, Szekeres, Gehrig, Gyöngyösi, Bergler-Klein. Comparison Of High-Sensitivity C-Reactive Protein Vs C-Reactive Protein For Cardiovascular Risk Prediction In Chronic Cardiac Disease. J Appl Lab Med 2022. https://doi.org/10.1093/jalm/jfac069
Boutaleb, Belkouchia, Badaoui, Arous, Benouna, Drighil, et al. Association Of C-Reactive Protein Levels With Angiographic Findings Among Patients With Non-ST-Segment Elevation Myocardial Infarction. Arch Cardiovasc Dis Suppl 2021;13:200–1. https://doi.org/10.1016/j.acvdsp.2021.04.134
Melnikov, Kozlov, Okhota, Saburova, Avtaeva, Kuznetsova, et al. Higher Monomeric C-Reactive Protein Levels Are Associated With Premature Coronary Artery Disease. Front Immunol 2025;15. https://doi.org/10.3389/fimmu.2024.1501125
B, Kr, N. A Prospective Study Of Congestive Cardiac Failure And Its Prognostication With 3C: Reactive Protein As A Marker Of Severity. Int J Cardiol Res 2020. https://doi.org/10.33545/26634104.2020.v2.i1a.17
Kuppa, Tripathi, Al-Darraji, Tarhuni, Abdel-Latif. C-Reactive Protein Levels And Risk Of Cardiovascular Diseases: A Two-Sample Bidirectional Mendelian Randomization Study. Int J Mol Sci 2023;24. https://doi.org/10.3390/ijms24119129
Tokuda, Tanaka, Tobe, Shirai, Kurobe, Kubota, et al. Impact Of C-Reactive Protein On Long-Term Cardiac Events In Stable Coronary Artery Disease Patients With Chronic Kidney Disease. J Atheroscler Thromb 2023;30:1635–43. https://doi.org/10.5551/jat.64047
Da Rocha Martinez. Landmarks On C-Reactive Protein As Inflammation Marker. Am J Med Clin Res & Rev 2024. https://doi.org/10.58372/2835-6276.1221
Liu, Xu, Qian, Zhou, Liu. C-Reactive Protein Level Predicts Cardiovascular Risk In Chinese Young Female Population. Oxid Med Cell Longev 2021;2021. https://doi.org/10.1155/2021/6538079
Naureen, Saleem, Naeem, Naeem, Nawaz. Study The Association Of C-Reactive Protein And Risk Of Cardiovascular Disease In Heart Patients Above The Age Of 50 Years 2021.
Umrani, Jamshed, Rizwan. Comparison Of Atorvastatin And Rosuvastatin In Reduction Of Inflammatory Markers In Acute Coronary Syndrome. Cureus 2020;12. https://doi.org/10.7759/cureus.11760
Anees, Raza, Farooq, Mumtaz. Correlation Between Acute Kidney Injury And Inflammatory Markers In Coronavirus Disease 2019. Pakistan J Kidney Dis 2022. https://doi.org/10.53778/pjkd61190
Malik, Malik, Sukhera, Khalid, Waqas, Qayyum, et al. Metabolic Syndrome And Related Inflammation, Prevalence, And Predictive Value Of C-Reactive Protein In South Asian Youths. Metab Syndr Relat Disord 2021. https://doi.org/10.1089/met.2021.0016
Ridker, Danielson, Fonseca, Genest, Gotto, Kastelein, et al. Rosuvastatin To Prevent Vascular Events In Men And Women With Elevated C-Reactive Protein From The Center For Cardiovascular Dis Ease Prevention (P. N Engl j Med 2008;21:359. https://doi.org/10.1056/nejmoa0807646
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