Efficacy of Transversus Abdominal Plane (TAP) block vs. Diclofenac Suppository for Management of Post-Operative Pain in Patients Undergoing Laparoscopic Cholecystectomy
DOI:
https://doi.org/10.70749/ijbr.v3i4.1112Keywords:
TAP block, Diclofenac suppository, Post-operative pain, Laparoscopic cholecystectomyAbstract
Background: Effective post-operative pain management enhances recovery and patient comfort following laparoscopic cholecystectomy. Objective: To evaluate and compare the analgesic efficacy of TAP block versus diclofenac suppository in patients undergoing elective laparoscopic cholecystectomy. Methods: This randomized controlled trial was conducted at the Department of General Surgery, Allama Iqbal Memorial Teaching Hospital, Sialkot. A total of 60 patients scheduled for elective laparoscopic cholecystectomy were randomly allocated into two groups: Group A received bilateral TAP block using the landmark technique, and Group B received a 200 mg diclofenac suppository. All patients received 20 mg/kg intravenous paracetamol. Pain was assessed using the Numeric Rating Scale (NRS) at 2 hours post-operatively. Results: The mean pain score at 2 hours was significantly lower in the TAP block group (2.4 ± 0.9) compared to the diclofenac group (3.8 ± 0.8) (p < 0.001). Rescue analgesia was required in 20% of patients in the TAP block group versus 60% in the diclofenac group (p = 0.003). No complications were reported in either group. Conclusion: The study concludes that the transversus abdominis plane (TAP) block is more effective than diclofenac rectal suppository in managing early post-operative pain after elective laparoscopic cholecystectomy. Patients receiving the TAP block reported significantly lower pain scores and needed less rescue analgesia within the first two hours post-surgery. Additionally, the TAP block showed a favorable safety profile, making it a reliable option in multimodal analgesia, particularly in settings where reducing systemic analgesic use is preferred for better patient outcomes.
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Honda M, Kumamaru H, Etoh T, Miyata H, Yamashita Y, Yoshida K, et al. Surgical risk and benefits of laparoscopic surgery for elderly patients with gastric cancer: a multicenter prospective cohort study. Gastric Cancer. 2018 Dec 11;22(4):845–52. https://doi.org/10.1007/s10120-018-0898-7
Small C, Laycock H. Acute postoperative pain management. British Journal of Surgery [Internet]. 2020 Jan 5;107(2). https://bjssjournals.onlinelibrary.wiley.com/doi/10.1002/bjs.11477
Oderda GM, Senagore AJ, Morland K, Iqbal SU, Kugel M, Liu S, et al. Opioid-related respiratory and gastrointestinal adverse events in patients with acute postoperative pain: prevalence, predictors, and burden. Journal of Pain & Palliative Care Pharmacotherapy. 2019 Oct 2;33(3-4):82–97. https://doi.org/10.1080/15360288.2019.1668902
Chen Y ‐Y. K, Boden KA, Schreiber KL. The role of regional anaesthesia and multimodal analgesia in the prevention of chronic postoperative pain: a narrative review. Anaesthesia. 2021 Jan;76(S1):8–17. https://doi.org/10.1111/anae.15256
Ismail S. Multimodal analgesia for cesarean section: Evolving role of transversus abdominis plane block. J Obstet Anaesth Crit Care. 2012;2:67–8 https://doi.org/10.4103/2249-4472.104729
Calderon-Ospina CA, Nava-Mesa MO, Arbeláez Ariza CE. Effect of Combined Diclofenac and B Vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) for Low Back Pain Management: Systematic Review and Meta-analysis. Pain Medicine. 2019 Sep 16; https://doi.org/10.1093/pm/pnz216
Dayi JO, Fyneface-Ogan S, Johnson UU. A Comparative Study of the Analgesic Efficacy of Transversus Abdominis Plane Block Alone Versus Transversus Abdominis Plane Block and Diclofenac Suppository in the Management of Post Caesarean Section Pain. African Journal of Anaesthesia and Intensive Care [Internet]. 2020;20(2):19–25. https://www.ajol.info/index.php/ajaic/article/view/229047
Tekeli AE, Eker E, Bartin MK, Öner MÖ. The efficacy of transversus abdominis plane block for postoperative analgesia in laparoscopic cholecystectomy cases: a retrospective evaluation of 515 patients. J Int Med Res. 2020 Aug;48(8):300060520944058. PMID: 32787595; PMCID: PMC7543107. https://doi.org/10.1177/0300060520944058.
Ismail, S., Mistry, A. A., Siddiqui, A. S., Aziz, A., Zuberi, N. (2023). The analgesic efficacy of ultrasound guided transversus abdominis plane block vs. local anesthetic infiltration technique in major gynecologic surgery: A randomized controlled trial. Journal of Anaesthesiology Clinical Pharmacology, 39(4), 557-564. https://doi.org/10.4103/joacp.joacp_78_22
Houben AM, Moreau AJ, Detry OM, Kaba A, Joris JL. Bilateral subcostal transversus abdominis plane block does not improve the postoperative analgesia provided by multimodal analgesia after laparoscopic cholecystectomy: A randomised placebo controlled trial. Eur J Anaesthesiol 2019;36:772 7. https://doi.org/10.1097/eja.0000000000001028
Cai Q, Gao ML, Chen GY, Pan LH. Transversus abdominis plane block versus wound infiltration with conventional local anesthetics in adult patients underwent surgery: A systematic review and meta analysis of randomized controlled trials. Biomed Res Int 2020;2020:8914953. https://doi.org/10.1155/2020/8914953
Zhou H, Ma X, Pan J, Shuai H, Liu S, Luo X, et al. Effects of transversus abdominis plane blocks after hysterectomy: A meta analysis of randomized controlled trials. J Pain Res 2018;11:2477 89. https://doi.org/10.2147/jpr.s172828
Dai L, Ling X, Qian Y. Effect of Ultrasound-Guided Transversus Abdominis Plane Block Combined with Patient-Controlled Intravenous Analgesia on Postoperative Analgesia After Laparoscopic Cholecystectomy: a Double-Blind, Randomized Controlled Trial. J Gastrointest Surg. 2022 Dec;26(12):2542-2550. Epub 2022 Sep 13. PMID: 36100826; PMCID: PMC9674727. https://doi.org/10.1007/s11605-022-05450-6.
Zhao T, Shen Z, Sheng S. The efficacy and safety of nefopam for pain relief during laparoscopic cholecystectomy: A meta-analysis. Medicine (Baltimore) 2018;97(10):e0089. https://doi.org/10.1097/MD.0000000000010089.
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