Significance of Mean Platelet Volume and Platelet Count in Ischemic Heart Disease

Kashaf Iqbal; Nasir Farooq Butt

doi:10.70749/ijbr.v3i4.1169

Authors

Kashaf Iqbal West Medical Ward, Mayo Hospital, Lahore, Pakistan.
Nasir Farooq Butt West Medical Ward, Mayo Hospital, Lahore, Pakistan.

DOI:

https://doi.org/10.70749/ijbr.v3i4.1169

Keywords:

Cardiovascular risk, Mean Platelet Volume, Ischemic heart disease, Platelet

Abstract

Background: Ischemic heart disease (IHD) is one of the main causes of death and illness, and platelet indices play a key part in how it works. Objective: To determine the frequency of IHD in patients presenting with chest pain and compare Mean Platelet Volume (MPV) and Platelet Count between IHD and non-IHD patients. Methodology: This descriptive case series was conducted at the Department of Cardiology & Internal Medicine, Mayo Hospital, Lahore, for the duration of three months from December 6, 2024 to March 5, 2025. Total 145 people between the ages of 18 and 65 who came in with chest pain were included. People with blood diseases, who were pregnant, or who were taking blood thinners were not allowed to participate. Blood samples were tested for MPV and PC, and an independent t-test and chi-square test were used to compare the results statistically. A p-value less than 0.05 was thought to be significant. Results: The average MPV was higher in people with IHD (10.7 ± 1.1 fl) than in people without IHD (9.5 ± 1.2 fl, p < 0.001). The platelet count was much lower in people with IHD (212.4 ± 53.8 × 10⁹/L) than in people without IHD (244.1 ± 49.2 × 10⁹/L, p = 0.003). Diabetes mellitus, high blood pressure, and smoking were all strongly linked to IHD (p = 0.002, p = 0.017, and p = 0.009, respectively). Conclusion: Elevated MPV and reduced platelet count are significantly associated with IHD, suggesting their potential role as biomarkers for cardiovascular risk assessment.

Downloads

Download data is not yet available.

References

Zhang H, Zheng X, Huang P, Guo L, Zheng Y, Zhang D, Ma X. The burden and trends of heart failure caused by ischaemic heart disease at the global, regional, and national levels from 1990 to 2021. European Heart Journal-Quality of Care and Clinical Outcomes. 2024 Nov 13:qcae094.

https://doi.org/10.1093/ehjqcco/qcae094.

Młynarska E, Czarnik W, Fularski P, Hajdys J, Majchrowicz G, Stabrawa M, Rysz J, Franczyk B. From atherosclerotic plaque to myocardial infarction—The leading cause of coronary artery occlusion. International Journal of Molecular Sciences. 2024 Jul 2;25(13):7295.

https://doi.org/10.3390/ijms25137295.

Boğa E. Measurement of mean platelet volume in the diagnosis of acute ischemic stroke and transient ischemic attack. Journal of Medicine and Palliative Care. 2025 Feb 2;6(1):7-12.

https://doi.org/10.47582/jompac.1590302.

Regassa DA, Nagaash RS, Habtu BF, Haile WB. Diagnostic significance of complete blood cell count and hemogram-derived markers for neonatal sepsis at Southwest Public Hospitals, Ethiopia. World Journal of Clinical Pediatrics. 2024 Jun 9;13(2):92392. https://doi.org/10.5409/wjcp.v13.i2.92392.

Poznyak AV, Orekhova VA, Sukhorukov VN, Melnichenko AA, Pleshko EM, Orekhov AN. Platelet Implication in Atherosclerosis Pathogenesis. Journal of Angiotherapy. 2024;8(1):1-8. https://doi.org/10.25163/angiotherapy.819385

Bravo GM, Annarapu G, Carmona E, Nawarskas J, Clark R, Novelli E, Alvidrez RI. Platelets in thrombosis and atherosclerosis: a double-edged sword. The American Journal of Pathology. 2024 Sep 1;194(9):1608-21.

https://doi.org/10.1016/j.ajpath.2024.05.010

Mitsis A, Myrianthefs M, Sokratous S, Karmioti G, Kyriakou M, Drakomathioulakis M, Tzikas S, Kadoglou NP, Karagiannidis E, Nasoufidou A, Fragakis N. Emerging Therapeutic Targets for Acute Coronary Syndromes: Novel Advancements and Future Directions. Biomedicines. 2024 Jul 26;12(8):1670. https://doi.org/10.3390/biomedicines12081670.

Levytskyi H, Sheiko V. Predicting the dynamics of organ failure in patients with acute pancreatitis depending on the mean platelet volume. Surgery Open Science. 2024 Jun 1;19:166-71. https://doi.org/10.1016/j.sopen.2024.04.011.

Galimzhanov A, Tun HN, Sabitov Y, Perone F, Kursat TM, Tenekecioglu E, Mamas MA. The prognostic value of mean platelet volume in patients with coronary artery disease: An updated systematic review with meta‐analyses. European journal of clinical investigation. 2024 Dec;54(12):e14295. https://doi.org/10.1111/eci.14295.

Ci, J., Zhai, Y., Wang, B. et al. Correlation between Blood Cadmium Levels and Platelet Characteristics, As Well As Their Impact on Susceptibility to Coronary Heart Disease: Findings from NHANES 2005–2018 Data. Cardiovasc Toxicol 24, 335–344 (2024).

https://doi.org/10.1007/s12012-024-09840-x

Ludhiadch A, Yadav P, Singh SK, Sulena, Munshi A. Evaluation of mean platelet volume and platelet count in ischemic stroke and its subtypes: focus on degree of disability and thrombus formation. International Journal of Neuroscience. 2024 May 3;134(5):503-10. https://doi.org/10.1080/00207454.2022.2118599

Arefnia M, Ariani TH, Ghodsirad M, Alirezaei T, Hosseinzadeh E, Amoui M, Pirayesh E, Norouzi G. Utilization of Mean Platelet Volume for Predicting Ischemic Heart Disease in Diabetic and Non-Diabetic Patients. Novelty in Biomedicine. 2025 Jan 1;13(1):39-45.

https://doi.org/10.22037/nbm.v13i1.46513.

Cassano, V., Armentaro, G., Iembo, D. et al. Mean platelet volume (MPV) as new marker of diabetic macrovascular complications in patients with different glucose homeostasis. Cardiovasc Diabetol 23, 89 (2024).

https://doi.org/10.1186/s12933-024-02177-3.

Fu FF, Chen X, Xing L. Association between ratio of white blood cells to mean platelet volume and coronary artery ectasia. Angiology. 2024 Oct;75(9):874-83. https://doi.org/10.1177/00033197231185920.

Hatamnejad MR, Medzikovic L, Dehghanitafti A, Rahman B, Vadgama A, Eghbali M. Role of Gut Microbial Metabolites in Ischemic and Non-Ischemic Heart Failure. International Journal of Molecular Sciences. 2025 Mar 2;26(5):2242. https://doi.org/10.3390/ijms26052242.

Mambo, A., Yang, Y., Mahulu, E. et al. Investigating the interplay of smoking, cardiovascular risk factors, and overall cardiovascular disease risk: NHANES analysis 2011–2018. BMC Cardiovasc Disord 24, 193 (2024). https://doi.org/10.1186/s12872-024-03838-7

Asta L, Falco D, Benedetto U, Porreca A, Majri F, Angelini GD, Sensi S, Di Giammarco G. Stroke after cardiac surgery: A risk factor analysis of 580,117 patients from UK National Adult Cardiac Surgical Audit cohort. Journal of Personalized Medicine. 2024 Jan 31;14(2):169. https://doi.org/10.3390/jpm14020169.

Młynarska E, Czarnik W, Fularski P, Hajdys J, Majchrowicz G, Stabrawa M, Rysz J, Franczyk B. From atherosclerotic plaque to myocardial infarction—The leading cause of coronary artery occlusion. International Journal of Molecular Sciences. 2024 Jul 2;25(13):7295. https://doi.org/10.3390/ijms25137295.

Ishida M, Sakai C, Kobayashi Y, Ishida T. Cigarette smoking and atherosclerotic cardiovascular disease. Journal of atherosclerosis and thrombosis. 2024 Mar 1;31(3):189-200. https://doi.org/10.5551/jat.RV22015.