Comparison of Efficacy of Combination Therapy (Tamsulosin + Solifenacin) Versus Monotherapy (Tamsulosin) Alone for Double J Stent Related Lower Urinary Tract Symptoms

Authors

  • Waleed Javaid Department of Urology, Allied Hospital II, Faisalabad Medical University, Faisalabad, Punjab, Pakistan.
  • Muhammad Akmal Department of Urology, Faisalabad Medical University, Faisalabad, Punjab, Pakistan.
  • Zaighum Sohail Department of Urology, Allied Hospital II, Faisalabad Medical University, Faisalabad, Punjab, Pakistan.
  • Munzir Bin Dastgir Department of Urology, Faisalabad Medical University, Faisalabad, Punjab, Pakistan.
  • Rana Farrukh Irshad Department of Urology, Faisalabad Medical University / CPSP, Faisalabad, Punjab, Pakistan.

DOI:

https://doi.org/10.70749/ijbr.v3i7.1770

Keywords:

Tamsulosin, Solifenacin, Double-J Stent, Lower Urinary Tract Symptoms, IPSS, Combination Therapy

Abstract

Objectives: To compare the efficacy of combination therapy (Tamsulosin + Solifenacin) versus monotherapy (Tamsulosin) in relieving DJ stent-related LUTS. Methodology: The study was conducted at Department of Urology, Allied Hospital, Faisalabad from 31 January 2025 to 30 April 2025. Sixty patients aged between 18 and 40 years who underwent unilateral DJ stent placement were selected through non-probability consecutive sampling and randomly divided into two groups: Group A received combination therapy, while Group B received monotherapy. The International Prostate Symptom Score (IPSS) questionnaire was administered at baseline and at four weeks following surgery to assess LUTS severity. Results: Patients in the combination group showed a significantly greater reduction in mean IPSS scores (from 9.55 ± 1.94 to 4.79 ± 1.92) compared to the monotherapy group (from 10.95 ± 2.17 to 6.33 ± 1.64), with a post-treatment p-value of 0.001. Conclusion: Combination therapy with Tamsulosin and Solifenacin is significantly more effective than Tamsulosin alone in managing DJ stent-related LUTS. These findings support the routine use of dual pharmacotherapy to improve symptom relief and patient comfort during stent indwelling.

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References

1. Anand, A., Dayapule, S., Krishna, B. M., Yamajala, S. S., & Chadalawada, N. R. (2021). Effects of tamsulosin and tamsulosin+solifenacin combination therapy for the treatment of ureteral stent related lower urinary tract symptoms. International Journal of Surgery Science, 5(4), 156-160.

https://doi.org/10.33545/surgery.2021.v5.i4c.779

2. Pérez-Fentes, D., Aranda-Pérez, J., De la Cruz, J. E., & Soria, F. (2022). Indications, complications and side effects of ureteral stents. Urinary Stents, 5-20.

https://doi.org/10.1007/978-3-031-04484-7_2

3. Tomer, N., Garden, E., Small, A., & Palese, M. (2021). Ureteral stent encrustation: Epidemiology, pathophysiology, management and current technology. Journal of Urology, 205(1), 68-77.

https://doi.org/10.1097/ju.0000000000001343

4. Sajid, M. T., Rehman, S. U., Akmal, M., Ahmad, H., Mirza, Z. I., & Mahmood, A. (2021). Comparison of solifenacin versus combination of solifenacin and tamsulosin in improving unilateral double-J stent related lower urinary tract symptoms - A prospective randomized control trial. Pakistan Armed Forces Medical Journal, 71(1), 45-50.

https://doi.org/10.51253/pafmj.v71i1.2617

5. Harper, J. D., Desai, A. C., Antonelli, J. A., Tasian, G. E., Ziemba, J. B., Al-Khalidi, H. R., Lai, H. H., Maalouf, N. M., Reese, P. P., Wessells, H. B., Kirkali, Z., & Scales, C. D. (2022). Quality of life impact and recovery after ureteroscopy and stent insertion: Insights from daily surveys in STENTS. BMC Urology, 22(1).

https://doi.org/10.1186/s12894-022-01004-9

6. Reddy, V. V. V., Repaka, A. K., Varma, R., & Ramadugu, A. (2023). A study on correlation of microbial culture of stent and symptomatology in patients with lower urinary tract symptoms (LUTS) after DJ stenting. Int J Acad Med Pharm, 5(5), 1201-1207.

https://doi.org/10.47009/jamp.2023.5.5.237

7. Song, Y., Chen, G., Huang, P., Hu, C., & Liu, X. (2020). Effects of Tamsulosin combined with Solifenacin on lower urinary tract symptoms: Evidence from a systematic review, meta-analysis, and trial sequential analysis of randomized controlled trials. Frontiers in Pharmacology, 11.

https://doi.org/10.3389/fphar.2020.00763

8. Ramachandra, M., Mosayyebi, A., Carugo, D., & Somani, B. K. (2020). Strategies to improve patient outcomes and QOL: Current complications of the design and placements of ureteric Stents. Research and Reports in Urology, 12, 303-314.

https://doi.org/10.2147/rru.s233981

9. Salih, E. M., Koritenah, A. K., Yehya, M., & Mourad, M. M. (2021). The efficacy of alpha-1A blocker (tamsulosin), antimuscarinic (solifenacin) and their combination in the management of double-J stent-related lower urinary tract symptoms: A randomized controlled study. African Journal of Urology, 27(1).

https://doi.org/10.1186/s12301-021-00142-0

10. Hasbi, B. E., Palinrungi, M. A., Kholis, K., Bakri, S., Syahrir, S., & Kasim, F. (2021). The effectiveness between Tamsulosin and Solifenacin combined with Tamsulosin on treatment of ureteral stent-related symptoms. Nusantara Medical Science Journal, 1-17.

https://doi.org/10.20956/nmsj.v6i1.14263

11. Jan Hafiz, A. U., Ali, S. W., & Khalid, S. (2022). The efficacy of tamsulosin and solifenacin versus tamsulosin alone in double-J stent associated with lower urinary tract symptoms. International Journal of Endorsing Health Science Research, 10(3), 313-318.

https://doi.org/10.29052/ijehsr.v10.i3.2022.313-318

12. Sajid, M. T., Rehman, S. U., Akmal, M., Ahmad, H., Mirza, Z. I., & Mahmood, A. (2021). Comparison of solifenacin versus combination of solifenacin and tamsulosin in improving unilateral double-J stent related lower urinary tract symptoms - A prospective randomized control trial. Pakistan Armed Forces Medical Journal, 71(1), 45-50.

https://doi.org/10.51253/pafmj.v71i1.2617

13. Tareq, A. I., & Islam, M. S. (2020). To compare the efficacy of Tamsulosin, Solifenacin and combination of both in the treatment of Double-J stent related irritative lower urinary tract symptoms and low back pain. Bangladesh Journal of Urology, 23(1), 48-51.

https://doi.org/10.3329/bju.v23i1.50289

14. Shalaby, E., Ahmed, A., Maarouf, A., Yahia, I., Ali, M., & Ghobish, A. (2013). Randomized controlled trial to compare the safety and efficacy of Tamsulosin, Solifenacin, and combination of both in treatment of Double-J stent-related lower urinary symptoms. Advances in Urology, 2013, 1-6.

https://doi.org/10.1155/2013/752382

15. Guitynavard, F., Gooran, S., Kasiri, P., Gholipour, F., & Aghamir, S. M. (2019). Effect of tamsulosin on lower urinary tract symptoms related to double-J ureteral stent: A randomised, double-blinded, placebo controlled trial. WCET Journal, 39(3), 26-31.

https://doi.org/10.33235/wcet.39.3.26-31

16. Hasbi, B. E., Palinrungi, M. A., Kholis, K., Bakri, S., Syahrir, S., & Kasim, F. (2021). The effectiveness between Tamsulosin and Solifenacin combined with Tamsulosin on treatment of ureteral stent-related symptoms. Nusantara Medical Science Journal, 1-17.

https://doi.org/10.20956/nmsj.v6i1.14263

17. Piedad, J. C., Allam, M., & Mahmalji, W. (2024). Pharmacological treatment of bladder stent symptoms. Bladder, 11(3), e21200012.

https://doi.org/10.14440/bladder.2024.0018

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Published

2025-07-08

Issue

Vol. 3 No. 7 (2025): Indus Journal of Bioscience Research

Section

Original Article

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Copyright (c) 2025 Indus Journal of Bioscience Research

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This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

Javaid, W., Akmal, M., Sohail, Z., Dastgir, M. B., & Irshad, R. F. (2025). Comparison of Efficacy of Combination Therapy (Tamsulosin + Solifenacin) Versus Monotherapy (Tamsulosin) Alone for Double J Stent Related Lower Urinary Tract Symptoms. Indus Journal of Bioscience Research, 3(7), 486-490. https://doi.org/10.70749/ijbr.v3i7.1770