Association of Hyperparathyroidism with Patients of Beta Thalassemia Major in a Tertiary Care Hospital

Zahid Ullah; Taqweem Ul Haq; Beenish Ejaz; Lubna Humayun; Muhammad Abdullah; Muhammad Zubair

doi:10.70749/ijbr.v3i8.2050

Authors

Zahid Ullah District Children Specialist, Women and Children Hospital, Karak, KP, Pakistan.
Taqweem Ul Haq House Officer, Abbottabad Medical Complex, Abbottabad, KP, Pakistan.
Beenish Ejaz Haematology/Pathology Department, Allama Iqbal Medical College, Lahore, Punjab, Pakistan.
Lubna Humayun Department of Pathology, University College of Medicine and Dentistry, The University of Lahore, Lahore, Punjab, Pakistan.
Muhammad Abdullah Medical Officer, University of Lahore Teaching Hospital, Lahore, Punjab, Pakistan.
Muhammad Zubair Associate Professor of Pathology, Saidu Medical College/Saidu Group of Teaching Hospitals, Swat, KP, Pakistan.

DOI:

https://doi.org/10.70749/ijbr.v3i8.2050

Keywords:

Association, Hyperparathyroidism, Beta Thalassemia Major.

Abstract

Background: Beta-thalassemia is an inherited disorder that leads to abnormity of hemoglobin. There is a significant frequency of endocrine disorders among beta thalassemia major patients. Objective: The aim of this study was to determine the Association of hyperparathyroidism with patients of beta thalassemia major in a tertiary care hospital. Material and method: The present study was carried out at women and children hospital karak after taking permission from the ethical board of the hospital. A total of 120 children already diagnosed with beta thalassemia major of both gender and different age groups were included. Children were evaluated by a detailed medical history and clinical examination. Blood samples were collected from children using extremely strict aseptic methods and forwarded to a medical laboratory for analysis. Serum levels of calcium, phosphorus, hemoglobin, and parathyroid hormone were checked. The participants’ bio data (name, age, gender, and address) was collected using a pre-designed proforma. The collected data was analyzed through SPSS version 20. Results: A total of 120 children with beta thalassemia major were evaluated in this study, out of which 90(75%) were male and 30(25%) were female. Biochemical data revealed a mean hemoglobin level of 11.48±2.70 mg/dl, with 48 (40%) having high serum ferritin, 47 (39.1%) had low serum calcium, 46 (38.3%) showed high serum phosphorus, and 46 (38.3%) reported low parathyroid hormone. Hypoparathyroidism has been noted in 38.3% of thalassemic individuals. There was no significant association between age or gender and hypoparathyroidism. This study found a substantial correlation between serum calcium, phosphorus, and parathyroid hormone levels and hypothyroidism in thalassemic individuals. PTH levels between 10-60 pg/ml were considered normal, but those below 10 pg/ml were classified as hypoparathyroid. Conclusion: The current study concluded that hyperparathyroidism had a prime association with beta thalassemia major. The frequency of hyperparathyroidism was 38.3% in the beta thalassemia major participants in the present study.

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