Are Lowered Blood Platelets Count an Indicator of Hypertension Among Pregnant Women
DOI:
https://doi.org/10.70749/ijbr.v3i7.2068Keywords:
Platelet Count, Hypertensive Disorders of Pregnancy, Gestational ThrombocytopeniaAbstract
Background: Pregnancy-related hypertensive conditions, including gestational hypertension and preeclampsia, are leading causes of morbidity and mortality among mothers and fetuses worldwide. Potential, affordable hematological markers that could help with early detection and monitoring of these disorders include platelet count and platelet indices. Objective: In order to assess their potential as diagnostic and prognostic tools in prenatal care, the purpose of this study was to determine if decreased platelet counts and changed platelet indices are signs of hypertension in pregnant women. Methods: A six-month qualitative study was carried out at a Quetta, Balochistan, tertiary care hospital. Purposive sampling was used to enroll 130 pregnant women in total. Standard blood pressure criteria and clinical observations were used to categorize the participants into normotensive and hypertensive groups. Platelet count, mean platelet volume (MPV), and platelet distribution width (PDW) were measured by whole blood counts. Frequency distribution tables and group comparisons were used to analyze the data. Results: According to the study, pregnant women with hypertension disorders had far lower platelet counts than normotensive women. Of these, 31.5% had mild thrombocytopenia (100,000–150,000 cells/mm³) and 23.1% had severe thrombocytopenia (<100,000 cells/mm³). Furthermore, higher platelet activation and turnover were indicated by the fact that 40.0% of hypertensive participants had increased platelet distribution width (PDW >16%) and 46.2% had elevated mean platelet volume (MPV >11 fL). Particularly in cases of pre-eclampsia and eclampsia, these hematological alterations were associated with the degree of hypertension. Conclusion: Pregnancy hypertension correlates with lower platelet counts, higher indices, aiding early, affordable detection in resource-limited settings.
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References
1. Pinto A. et al. (1991). hypertension in pregnancy: characteristics, management, and outcomes. American Journal of Obstetrics and Gynecology.
2. Sonmez, O., & Sonmez, M. (2017). Role of platelets in immune system and inflammation. Porto Biomedical Journal, 2(6), 311-314. https://doi.org/10.1016/j.pbj.2017.05.005
3. Pogorzelska, K., Krętowska, A., Krawczuk-Rybak, M., & Sawicka-Żukowska, M. (2020). Characteristics of platelet indices and their prognostic significance in selected medical condition – a systematic review. Advances in Medical Sciences, 65(2), 310-315. https://doi.org/10.1016/j.advms.2020.05.002
4. Rolnik, D. L., Nicolaides, K. H., & Poon, L. C. (2022). Prevention of preeclampsia with aspirin. American journal of obstetrics and gynecology, 226(2), S1108-S1119. https://doi.org/10.1016/j.ajog.2020.08.045
5. Golebiewska, E. M., & Poole, A. W. (2015). Platelet secretion: From haemostasis to wound healing and beyond. Blood Reviews, 29(3), 153-162. https://doi.org/10.1016/j.blre.2014.10.003
6. Harris, P. A., Taylor, R., Minor, B. L., Elliott, V., Fernandez, M., O'Neal, L., McLeod, L., Delacqua, G., Delacqua, F., Kirby, J., & Duda, S. N. (2019). The redcap consortium: Building an international community of software platform partners. Journal of Biomedical Informatics, 95, 103208. https://doi.org/10.1016/j.jbi.2019.103208
7. P.A. Harris et al. support Biomed Inform (2009)
8. Felfernig-Boehm, D., Salat, A., Vogl, S. E., Murabito, M., Felfernig, M., Schmidt, D., Mittlboeck, M., Husslein, P., & Mueller, M. R. (2000). Early detection of Preeclampsia by determination of platelet Aggregability. Thrombosis Research, 98(2), 139-146. https://doi.org/10.1016/s0049-3848(99)00224-8
9. CHU, S., BECKER, R., BERGER, P., BHATT, D., EIKELBOOM, J., KONKLE, B., MOHLER, E., REILLY, M., & BERGER, J. (2010). Mean platelet volume as a predictor of cardiovascular risk: A systematic review and meta‐analysis. Journal of Thrombosis and Haemostasis, 8(1), 148-156. https://doi.org/10.1111/j.1538-7836.2009.03584.x
10. Ford, N. D., Cox, S., Ko, J. Y., Ouyang, L., Romero, L., Colarusso, T., Ferre, C. D., Kroelinger, C. D., Hayes, D. K., & Barfield, W. D. (2022). Hypertensive disorders in pregnancy and mortality at delivery hospitalization — United States, 2017–2019. MMWR. Morbidity and Mortality Weekly Report, 71(17), 585-591. https://doi.org/10.15585/mmwr.mm7117a1
11. Juan, P., Stefano, G., Antonella, S., & Albana, C. (2011). Platelets in pregnancy. Journal of prenatal medicine, 5(4), 90. https://pmc.ncbi.nlm.nih.gov/articles/PMC3399052/
12. Tesfay, F., Negash, M., Alemu, J., Yahya, M., Teklu, G., Yibrah, M., Asfaw, T., & Tsegaye, A. (2019). Role of platelet parameters in early detection and prediction of severity of preeclampsia: A comparative cross-sectional study at Ayder comprehensive specialized and Mekelle general hospitals, Mekelle, Tigray, Ethiopia. PLOS ONE, 14(11), e0225536. https://doi.org/10.1371/journal.pone.0225536
13. Fitzgerald, D. J., Entman, S. S., Mulloy, K., & FitzGerald, G. A. (1987). Decreased prostacyclin biosynthesis preceding the clinical manifestation of pregnancy-induced hypertension. Circulation, 75(5), 956-963. https://doi.org/10.1161/01.cir.75.5.956
14. Wagner, D. D., & Burger, P. C. (2003). Platelets in inflammation and thrombosis. Arteriosclerosis, thrombosis, and vascular biology, 23(12), 2131-2137. https://doi.org/10.1161/01.ATV.0000095974.95122.EC
15. Vigil-De Gracia, P., Montufar-Rueda, C., & Ruiz, J. (2003). Expectant management of severe preeclampsia and preeclampsia superimposed on chronic hypertension between 24 and 34 weeks’ gestation. European Journal of Obstetrics & Gynecology and Reproductive Biology, 107(1), 24-27. https://doi.org/10.1016/s0301-2115(02)00269-5
16. Barron WM, Murphy MB, Lindheimer MD. In: Raven Laragh GH, Brenner BM, eds. Management of Hypertension during Pregnancy. New York: Hypertension pathophysiology, diagnosis and management. 3rd ed. vol. 2. 1990:1809e1827.
17. Taylor RN. Pregnancy. Am J Obstet Gynecol. 1990;163:1691e1712.
18. Prabhakaran, D., & Yusuf, S. (2010). Cardiovascular disease in India: Lessons learnt & challenges ahead. Indian Journal of Medical Research, 132(5), 529-530. https://doi.org/10.4103/ijmr.2010_132_05_529
19. Kaito, K., Otsubo, H., Usui, N., Yoshida, M., Tanno, J., Kurihara, E., Matsumoto, K., Hirata, R., Domitsu, K., & Kobayashi, M. (2005). Platelet size deviation width, platelet large cell ratio, and mean platelet volume have sufficient sensitivity and specificity in the diagnosis of immune thrombocytopenia. British Journal of Haematology, 128(5), 698-702. https://doi.org/10.1111/j.1365-2141.2004.05357.x
20. Khandekar, M. M., Khurana, A. S., Deshmukh, S. D., Kakrani, A. L., Katdare, A. D., & Inamdar, A. K. (2006). Platelet volume indices in patients with coronary artery disease and acute myocardial infarction: An Indian scenario. Journal of Clinical Pathology, 59(2), 146-149. https://doi.org/10.1136/jcp.2004.025387
21. Dey M, Singh S, Bhattacharjee S. Platelet parameters as a biomarker in preeclampsia. Journal of Clinical and Diagnostic Research. 2021;15(2):QC01–QC04.
22. Akinbami AA, Ajibola SO, Rabiu KA, et al. Mean platelet volume in women with preeclampsia. Open Journal of Obstetrics and Gynecology. 2016;6(11):657–664
23. AlSheeha, M. A., Alaboudi, R. S., Alghasham, M. A., Iqbal, J., & Adam, I. (2016). Platelet count and platelet indices in women with preeclampsia. Vascular health and risk management, 477-480. https://doi.org/10.2147/VHRM.S120944
24. Sultana S, Karim N, Ahmed S, Jahan S. (2020). Evaluation of platelet indices in hypertensive disorders of pregnancy. Journal of Dhaka Medical College, 29(1), 15–20.
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