Correlation of Coagulation Profile with Injury Severity in Road Traffic Accident Patients
DOI:
https://doi.org/10.70749/ijbr.v3i7.2113Keywords:
Coagulation Profile, Injury Severity, Road Traffic Accidents, Trauma Patients.Abstract
Background: Road Traffic Accidents (RTAs) are a significant cause of morbidity and mortality worldwide. Trauma-induced coagulopathy is a common and life-threatening complication observed in severely injured patients. Objective: This study aimed to assess the correlation between coagulation profiles and injury severity among patients involved in road traffic accidents. Methods: A cross-sectional descriptive study was conducted at Mufti Mehmood Memorial Teaching Hospital and the A&E Department of DHQ Hospital, Dera Ismail Khan. A total of 230 patients with moderate to severe injuries were recruited. Coagulation profiles (PT, APTT, INR, platelet count) were measured upon admission, and the Injury Severity Score (ISS) was calculated for each patient. Data were analyzed using SPSS version 23, with significance set at p < 0.05. Results: Out of 230 trauma patients, 67.8% were male, and 32.2% were female. The mean age was 36.4 ± 12.7 years. A majority of patients presented with moderate to severe trauma based on ISS. Thrombocytopenia was found in 29% of patients. Prolonged PT and APTT were observed in 46% and 38% of cases respectively. Elevated D-dimer levels were noted in 52%, and low fibrinogen levels were found in 33% of patients. Statistical analysis revealed a significant correlation between abnormal coagulation parameters and higher ISS scores. DIC scores were significantly elevated in patients with severe trauma, suggesting a strong link between coagulopathy and injury severity. Abnormal PT, APTT, and INR levels were significantly associated with higher injury severity scores (p < 0.05). Platelet counts showed moderate correlation with injury severity. The data suggests that abnormal coagulation profiles are prevalent among RTA patients with severe injuries. Conclusion: There is a significant correlation between coagulation abnormalities and injury severity in road traffic accident patients. Early assessment of coagulation profiles may aid in the risk stratification and timely management of trauma patients.
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References
1. Thakur, D., Sharma, M., & Lohani, I. (2016). Correlation of Coagulopathy of trauma and revised trauma score in predicting outcome in trauma patients. Journal of Institute of Medicine Nepal, 38(2&3), 105-111.
https://doi.org/10.59779/jiomnepal.907
2. Kulkarni, K. K., Bhandari, A. P., & Rathod, P. (2021). Study of coagulation profile in patients admitted to a trauma center in a tertiary care hospital. Journal of Applied Hematology, 12(1), 26-30.
https://doi.org/10.4103/joah.joah_151_20
3. Mukhopadhyay, A., Chhabra, G., Sharma, S., Subramanian, A., Agrawal, D., & Sinha, S. (2013). Coagulopathy as prognostic marker in acute traumatic brain injury. Journal of Emergencies, Trauma, and Shock, 6(3), 180.
https://doi.org/10.4103/0974-2700.115332
4. MacLeod, J. B., Lynn, M., McKenney, M. G., Cohn, S. M., & Murtha, M. (2003). Early Coagulopathy predicts mortality in trauma. The Journal of Trauma: Injury, Infection, and Critical Care, 55(1), 39-44.
https://doi.org/10.1097/01.ta.0000075338.21177.ef
5. Ashraf, F., Ibrahim, M. F., Feroz, R., Wasey, A., Arsalan, M., & Quraishy, M. S. (2021). Acute trauma coagulopathy: Prevalence and outcome in trauma patients presenting to the emergency department SMBB trauma centre, civil hospital Karachi.
https://doi.org/10.21203/rs.3.rs-183028/v1
6. Derakhshanfar, H., Vafaei, A., Tabatabaey, A., & Noori, S. (2017). Prevalence and associated factors of acute traumatic coagulopathy; a cross sectional study. Emergency, 5(1), e58.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5585828/
7. Raffee, L. A., Oteir, A. O., Alawneh, K. Z., & Alustath, A. M. (2020). Relationship between initial arterial blood gases and coagulation profiles–analyzing the prognosis and outcomes in patients with multiple injuries/trauma. Open Access Emergency Medicine, 12, 87-92.
https://doi.org/10.2147/oaem.s244941
8. Krishna, G., Aggarwal, V., & Singh, I. (2021). Prospective analysis of Coagulopathy associated with isolated traumatic brain injury and clinical outcome. Indian Journal of Neurosurgery, 11(03), 253-259.
https://doi.org/10.1055/s-0041-1728989
9. Caspers, M., Schäfer, N., Bouillon, B., Schaeben, V., Ciorba, M. C., Maegele, M., Müller, J., & Pötzsch, B. (2022). Plasmatic coagulation profile after major traumatic injury: A prospective observational study. European Journal of Trauma and Emergency Surgery, 48(6), 4595-4606.
https://doi.org/10.1007/s00068-022-01971-6
10. Nardi, G., Agostini, V., Rondinelli, B., Russo, E., Bastianini, B., Bini, G., Bulgarelli, S., Cingolani, E., Donato, A., Gambale, G., & Ranaldi, G. (2015). Trauma-induced coagulopathy: Impact of the early coagulation support protocol on blood product consumption, mortality and costs. Critical Care, 19(1).
https://doi.org/10.1186/s13054-015-0817-9
11. Hess, J. R., Lindell, A. L., Stansbury, L. G., Dutton, R. P., & Scalea, T. M. (2008). The prevalence of abnormal results of conventional coagulation tests on admission to a trauma center. Transfusion, 49(1), 34-39.
https://doi.org/10.1111/j.1537-2995.2008.01944.x
12. World Health Organization. (2023). Global status report on road safety 2023. Geneva.
13. Pasha HA, Tariq M, Yousuf MA. Burden of road traffic injuries in Pakistan: challenges and the way forward. Pak J Med Sci. 2021;37(3):881–6.
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