Frequency of Urinary Tract Infection (UTI) in Febrile Children
DOI:
https://doi.org/10.70749/ijbr.v3i7.2265Keywords:
Urinary tract infection, Febrile children, Frequency, Risk factors.Abstract
Background: UTI is a major cause of fever in children and is often asymptomatic with no particular urinary symptoms, especially in infants and toddlers. Renal complications, scarring and recurring infections are expected to be prevented by early detection and treatment. The frequency of UTI in febrile children can be determined with the assistance of determining the proper diagnostics tests. Objective: To identify the Frequency of urinary tract infection in febrile children and to identify demographic variables related to higher risk in order to enhance clinical suspicion and diagnostic yield. Study design: A cross-sectional study. Place and duration of study: Paediatrics Department of Bolan Medical Complex Hospital, Quetta, from January 2025 to May 2025. Methods: This cross-sectional investigation was carried out among 100 febrile children aged between 2 months to 12 years of age who presented without a definite source of infection. Urine samples were collected by clean-catch or catheterized urine samples and sent to undergo urinalysis and culture. The demographic information, clinical presentation and lab results were documented. Mean, standard deviation and chi-square test were performed with a significant p < 0.05. Findings: 100 febrile children were recruited, and the average age of them was 3.8 +- 2.1 years. Among them, 12 (12%) or were diagnosed with UTI with positive cultures of urine. The proportion was bigger among females (16%) than among males (8%) (p = 0.04). In male children, UTI was much higher in uncircumcised boys (14%) than those who had been circumcised (3%) (p = 0.02). A high frequency of UTI was also related to fever [?]39degC (p = 0.03). Conclusion: UTI is a frequent etiologic agent of fever in children, especially in girls and in uncircumcised boys. In high-risk groups, routine urine tests must be considered in febrile children with an unexplained origin. Complications can be avoided and the burden of recurrent urinary infections can be decreased by early detection and treatment.
Downloads
References
1. Belyayeva M, Leslie SW, Jeong JM. Acute Pyelonephritis. StatPearls. Treasure Island (FL) ineligible companies. Disclosure: Stephen Leslie declares no relevant financial relationships with ineligible companies. Disclosure: Jordan Jeong declares no relevant financial relationships with ineligible companies.: StatPearls Publishing. Copyright © 2025, StatPearls Publishing LLC.; 2025.
2. Buettcher M, Trueck J, Niederer-Loher A, Heininger U, Agyeman P, Asner S, et al. Swiss consensus recommendations on urinary tract infections in children. European journal of pediatrics. 2021;180(3):663-74.
https://doi.org/10.1007/s00431-020-03714-4
3. Doval L, Paye-Jaouen A, Pierucci UM, Lachkar AA, Duneton C, Lopez P, et al. Incidence of febrile post-procedural urinary tract infection following voiding cystourethrography in children without prior urine culture. World journal of urology. 2024;42(1):499.
https://doi.org/10.1007/s00345-024-05217-5
4. Hamilton JL, Evans SG, Bakshi M. Management of Fever in Infants and Young Children. American family physician. 2020;101(12):721-9.
5. Horsager TH, Hagstrøm S, Skals R, Winding L. Renal scars in children with febrile urinary tract infection - Looking for associated factors. Journal of pediatric urology. 2022;18(5):682.e1-.e9.
https://doi.org/10.1016/j.jpurol.2022.09.012
6. Hum S, Liu H, Shaikh N. Risk Factors for the Development of Febrile Recurrences in Children with a History of Urinary Tract Infection. The Journal of pediatrics. 2022;243:152-7.
https://doi.org/10.1016/j.jpeds.2021.12.037
7. Karamian A, Modiri R, Hosseinirad H, Firouzi M. Urinary Tract Infection in Infants <1 Month of Age: Demographic, Clinical, and Microbiological Characteristics. Infectious disorders drug targets. 2023;23(3):e161122210959.
https://doi.org/10.2174/1871526523666221116103202
8. Lejarzegi A, Fernandez-Uria A, Gomez B, Velasco R, Benito J, Mintegi S. Febrile Urinary Tract Infection in Infants Less Than 3 Months of Age. The Pediatric infectious disease journal. 2023;42(8):e278-e82.
https://doi.org/10.1097/inf.0000000000003947
9. Lotfollahzadeh S, Leslie SW, Aeddula NR. Vesicoureteral Reflux. StatPearls. Treasure Island (FL) with ineligible companies. Disclosure: Stephen Leslie declares no relevant financial relationships with ineligible companies. Disclosure: Narothama Aeddula declares no relevant financial relationships with ineligible companies.: StatPearls Publishing. Copyright © 2025, StatPearls Publishing LLC.; 2025.
10. Marzuillo P, Guarino S, Sessa AD, Liguori L, Rambaldi PF, Belfiore MP, et al. Evolution of congenital anomalies of urinary tract in children with and without solitary kidney. Pediatric research. 2022;92(3):767-75.
https://doi.org/10.1038/s41390-021-01781-3
11. Montini G, Tessitore A, Console K, Ronfani L, Barbi E, Pennesi M. Short Oral Antibiotic Therapy for Pediatric Febrile Urinary Tract Infections: A Randomized Trial. Pediatrics. 2024;153(1).
https://doi.org/10.1542/peds.2023-062598
12. Nakanishi K, Okutani T, Kotani S, Kamoi Y, Kim S, Yamane M. Risk factors for cefazolin-resistant febrile urinary tract infection in children. Pediatrics international : official journal of the Japan Pediatric Society. 2022;64(1):e15046.
https://doi.org/10.1111/ped.15046
13. Neheman A, Sabler IM, Beberashvili I, Goltsman G, Verchovsky G, Kord E, et al. Ureteral Stent Colonization and Urinary Tract Infection in Children Undergoing Minimally Invasive Pyeloplasty. European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery [et al] = Zeitschrift fur Kinderchirurgie. 2023;33(1):47-52.
https://doi.org/10.1055/a-1905-4460
14. Okada M, Kijima E, Yamamura H, Nakatani H, Yokoyama H, Imai M, et al. Obesity and febrile urinary tract infection in young children. Pediatrics international : official journal of the Japan Pediatric Society. 2022;64(1):e14686.
https://doi.org/10.1111/ped.14686
15. Overland MR, Trandem K, Allen IE, Copp HL. Revisiting the utility of prenatal ultrasound in the routine workup of first febrile UTI: A systematic review and meta-analysis of the negative predictive value of prenatal ultrasound for identification of urinary tract abnormalities after first febrile urinary tract infection in children. Journal of pediatric urology. 2023;19(6):754-65.
https://doi.org/10.1016/j.jpurol.2023.08.020
16. Qadir S, Memon S, Chohan MN, Memon Y. Frequency of Vitamin-D deficiency in children with Urinary tract infection: A descriptive cross-sectional study. Pakistan journal of medical sciences. 2021;37(4):1058-62.
https://doi.org/10.12669/pjms.37.4.3896
17. Rohner K, Mazzi S, Buder K, Weitz M. Febrile Urinary Tract Infections in Children with Primary Non-Refluxing Megaureter: A Systematic Review and Meta-Analysis. Klinische Padiatrie. 2022;234(1):5-13.
https://doi.org/10.1055/a-1303-4695
18. Rosenblad T, Lindén M, Ambite I, Brandström P, Hansson S, Godaly G. Genetic determinants of renal scarring in children with febrile UTI. Pediatric nephrology (Berlin, Germany). 2024;39(9):2703-15.
https://doi.org/10.1007/s00467-024-06394-6
19. t Hoen LA, Bogaert G, Radmayr C, Dogan HS, Nijman RJM, Quaedackers J, et al. Update of the EAU/ESPU guidelines on urinary tract infections in children. Journal of pediatric urology. 2021;17(2):200-7.
https://doi.org/10.1016/j.jpurol.2021.01.037
20. Tanaka Y, Oishi T, Ono S, Kono M, Kato A, Miyata I, et al. Epidemiology of urinary tract infections in children: Causative bacteria and antimicrobial therapy. Pediatrics international : official journal of the Japan Pediatric Society. 2021;63(10):1198-204.
https://doi.org/10.1111/ped.14639
21. Vachvanichsanong P, McNeil EB, Dissaneewate P. Extended-spectrum beta-lactamase Escherichia coli and Klebsiella pneumoniae urinary tract infections. Epidemiology and infection. 2020;149:e12.
https://doi.org/10.1017/s0950268820003015
22. Vazouras K, Velali K, Tassiou I, Anastasiou-Katsiardani A, Athanasopoulou K, Barbouni A, et al. Antibiotic treatment and antimicrobial resistance in children with urinary tract infections. Journal of global antimicrobial resistance. 2020;20:4-10.
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Indus Journal of Bioscience Research

This work is licensed under a Creative Commons Attribution 4.0 International License.