Prevalence of Acute Kidney Injury (AKI) in Females with Pre-Eclampsia in Tertiary Care Hospital
DOI:
https://doi.org/10.70749/ijbr.v3i7.2346Keywords:
Acute Kidney Injury, Pre-eclampsia, Females, Pregnancy.Abstract
Objective: To determine the prevalence of acute kidney injury (AKI) in females with pre-eclampsia in a tertiary care hospital setting. Study Design: Cross-sectional study. Place and Duration of Study: Department of Obstetrics and Gynecology, Jinnah Postgraduate Medical Centre (JPMC), Karachi, over a period of Three months from 20th March, 2025 to 20th June, 2025. Methodology: A total of 78 females aged 18–45 years with singleton pregnancies and a clinical diagnosis of pre-eclampsia after 20 weeks of gestation were enrolled using non-probability consecutive sampling. Patients with a prior history of renal disease, multiple gestations, fetal anomalies, or nephrotoxic drug use were excluded. Serum creatinine was measured, and the diagnosis and staging of AKI were done according to the RIFLE criteria. Data were analyzed using SPSS version 20. Chi-square test was applied to evaluate associations, with a p-value ≤ 0.05 considered statistically significant. Results: The mean age of participants was 29.8 ± 5.6 years, and the mean gestational age was 33.2 ± 3.4 weeks. Among 78 women, 19 (24.4%) were diagnosed with AKI. Of these, 9 (47.4%) had Stage 1, 6 (31.6%) had Stage 2, and 4 (21.0%) had Stage 3 AKI. AKI was significantly more prevalent among patients with severe pre-eclampsia (p = 0.02). Additionally, a higher frequency of AKI was observed in women with a history of diabetes and chronic hypertension. Conclusion: A substantial proportion of females with pre-eclampsia developed AKI, particularly those with severe disease and comorbidities such as diabetes and hypertension. Routine renal function assessment should be incorporated into antenatal care protocols for early detection and prevention of complications related to AKI.
Downloads
References
1. Gestational hypertension and Preeclampsia. (2020). Obstetrics & Gynecology, 135(6), e237-e260.
https://doi.org/10.1097/aog.0000000000003891
2. Vigil-De Gracia, P., Vargas, C., Sánchez, J., & Collantes-Cubas, J. (2023). Preeclampsia: Narrative review for clinical use. Heliyon, 9(3), e14187.
https://doi.org/10.1016/j.heliyon.2023.e14187
3. Ives, C. W., Sinkey, R., Rajapreyar, I., Tita, A. T., & Oparil, S. (2020). Preeclampsia—Pathophysiology and clinical presentations. Journal of the American College of Cardiology, 76(14), 1690-1702.
https://doi.org/10.1016/j.jacc.2020.08.014
4. Phipps, E. A., Thadhani, R., Benzing, T., & Karumanchi, S. A. (2019). Pre-eclampsia: Pathogenesis, novel diagnostics and therapies. Nature Reviews Nephrology, 15(5), 275-289.
https://doi.org/10.1038/s41581-019-0119-6
5. Rana, S., Lemoine, E., Granger, J. P., & Karumanchi, S. A. (2019). Preeclampsia. Circulation Research, 124(7), 1094-1112.
https://doi.org/10.1161/circresaha.118.313276
6. Taj, I., Naqvi, K. Z., Mushtaq, N., & Abbas, H. Y. (2022). Acute kidney injury during pregnancy and puerperium. Pakistan Journal of Medical and Health Sciences, 16(7), 906-908.
https://doi.org/10.53350/pjmhs22167906
7. Hassan, M., Mayanja, R., Ssalongo, W. G., Robert, N., Mark, L. H., Samson, O., & Muhindo, R. (2022). Incidence and predictors of acute kidney injury among women with severe pre-eclampsia at Mbarara regional referral hospital. BMC Nephrology, 23(1).
https://doi.org/10.1186/s12882-022-02972-8
8. Rasool, B., Akbar, H., Muhammad, A., & Riaz Malik, M. (2021). Frequency of pre-eclampsia induced acute kidney injury. Pakistan Journal of Medical and Health Sciences, 15(10), 2580-2581.
https://doi.org/10.53350/pjmhs2115102580
9. Conti-Ramsden, F. I., Nathan, H. L., De greeff, A., Hall, D. R., Seed, P. T., Chappell, L. C., Shennan, A. H., & Bramham, K. (2019). Pregnancy-related acute kidney injury in Preeclampsia. Hypertension, 74(5), 1144-1151.
https://doi.org/10.1161/hypertensionaha.119.13089
10. Liu Z, Qian Y, Zhang Y, Liu Y. Incidence and risk factors of pregnancy-related acute kidney injury in preeclamptic patients. Clin Nephrol. 2020;93(3):141–7.
11. Siddiqui A, Hafeez R, Rizvi F. Acute kidney injury in obstetric patients: A tertiary hospital experience in a developing country. Cureus. 2021;13(3):e13733.
12. Goplani, K., Shah, P., Gera, D., Gumber, M., Dabhi, M., Feroz, A., Kanodia, K., Suresh, S., Vanikar, A., & Trivedi, H. (2008). Pregnancy-related acute renal failure: A single-center experience. Indian Journal of Nephrology, 18(1), 17.
https://doi.org/10.4103/0971-4065.41283
13. Mehrabadi A, Liu S, Bartholomew S, Hutcheon JA, Kramer MS, Liston RM, et al. Temporal trends in incidence of pregnancy-related acute renal failure in Canada: a population-based study. J Obstet Gynaecol Can. 2014;36(1):21–27.
14. August P, Podymow T. Hypertension in pregnancy. In: Taler SJ, editor. Current Diagnosis & Treatment: Hypertension. 1st ed. New York: McGraw-Hill Education; 2021. p. 241–66.
15. Ray, J. G., Vermeulen, M. J., Schull, M. J., & Redelmeier, D. A. (2005). Cardiovascular health after maternal placental syndromes (CHAMPS): Population-based retrospective cohort study. The Lancet, 366(9499), 1797-1803.
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Indus Journal of Bioscience Research
This work is licensed under a Creative Commons Attribution 4.0 International License.
