Frequency of Eosinophilia in Patients Presenting with Bronchial Asthma Presenting at Tertiary Care Hospital
DOI:
https://doi.org/10.70749/ijbr.v3i7.2399Keywords:
Asthma, Blood Eosinophil Count, Chronic Disease, Pulmonary Function, SmokingAbstract
Background: Bronchial asthma is a chronic inflammatory disorder of the airways, characterized by recurrent episodes of airflow obstruction, bronchial hyperresponsiveness, and symptoms such as wheezing, cough, chest tightness, and shortness of breath. Eosinophilia, an elevated count of eosinophilic granulocytes in peripheral blood, reflects ongoing immunoinflammatory activity and serves as a biomarker for disease severity and therapeutic guidance. Objective: To determine the frequency of eosinophilia in patients presenting with bronchial asthma presenting at tertiary care hospital. Study Design: Descriptive cross-sectional study. Duration and Place of Study: The study was conducted from 23 March 2025 to 23 June 2025 at the Department of Pulmonology, Saidu Group of Teaching Hospitals, Swat. Methodology: A total of 143 patients aged 18–70 years, diagnosed with bronchial asthma based on characteristic symptoms and spirometry criteria, were enrolled using non-probability consecutive sampling. Patients with allergic bronchopulmonary aspergillosis, chronic obstructive pulmonary disease, or systemic corticosteroid therapy were excluded. Venous blood samples were collected to measure absolute eosinophil counts, with eosinophilia defined as greater than 500 cells per microliter. Demographic information and comorbidities were recorded. Results: The mean age was 42.44 ± 11.63 years, with 42% males and 58% females. Eosinophilia was present in 44.8% of patients. Younger age, rural residence, and smoking were significantly associated with elevated eosinophil counts. Comorbidities such as diabetes and hypertension showed no significant association. Conclusion: Eosinophilia is a common inflammatory marker in nearly half of patients with bronchial asthma, with age, environmental exposure, and smoking status being important determinants.
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References
1. Koefoed, H. J., Zwitserloot, A. M., Vonk, J. M., & Koppelman, G. H. (2021). Asthma, bronchial hyperresponsiveness, allergy and lung function development until early adulthood: A systematic literature review. Pediatric Allergy and Immunology, 32(6), 1238-1254.
https://doi.org/10.1111/pai.13516
2. Wang, Y., & Liu, L. (2024). Immunological factors, important players in the development of asthma. BMC Immunology, 25(1).
https://doi.org/10.1186/s12865-024-00644-w
3. Pham, D. L., Le, K., Truong, D. D., Le, H. T., & Trinh, T. H. (2023). Environmental allergen reduction in asthma management: An overview. Frontiers in Allergy, 4.
https://doi.org/10.3389/falgy.2023.1229238
4. Gohal, G., Moni, S. S., Bakkari, M. A., & Elmobark, M. E. (2024). A review on asthma and allergy: Current understanding on molecular perspectives. Journal of Clinical Medicine, 13(19), 5775.
https://doi.org/10.3390/jcm13195775
5. Menzel, A., Samouda, H., Dohet, F., Loap, S., Ellulu, M. S., & Bohn, T. (2021). Common and novel markers for measuring inflammation and oxidative stress ex vivo in research and clinical practice—Which to use regarding disease outcomes? Antioxidants, 10(3), 414.
https://doi.org/10.3390/antiox10030414
6. Kim, C., Callaway, Z., & Pawankar, R. (2023). Eosinophil granule proteins as a biomarker in managing asthma and allergies. Asia Pacific Allergy, 13(2), 66-71.
https://doi.org/10.5415/apallergy.0000000000000104
7. Graf, L., Radtke, D., & Voehringer, D. (2025). Regulation of eosinophil recruitment and heterogeneity during allergic airway inflammation. Frontiers in Allergy, 6.
https://doi.org/10.3389/falgy.2025.1585142
8. Porpodis, K., Tsiouprou, I., Apostolopoulos, A., Ntontsi, P., Fouka, E., Papakosta, D., Vliagoftis, H., & Domvri, K. (2022). Eosinophilic asthma, phenotypes-endotypes and current biomarkers of choice. Journal of Personalized Medicine, 12(7), 1093.
https://doi.org/10.3390/jpm12071093
9. Hussain, M., & Liu, G. (2024). Eosinophilic asthma: Pathophysiology and therapeutic horizons. Cells, 13(5), 384.
https://doi.org/10.3390/cells13050384
10. Chandrasekara, S., & Wark, P. (2024). Biologic therapies for severe asthma with persistent type 2 inflammation. Australian Prescriber, 47(2), 36-42.
https://doi.org/10.18773/austprescr.2024.015
11. Wu, C. (2023). Research progress of serum eosinophil in chronic obstructive pulmonary disease and asthma. Open Life Sciences, 18(1).
https://doi.org/10.1515/biol-2022-0779
12. Yasin, M., Adeel, M., Muhammad, M., Sadaf, S., Tareen, S., & Jan, F. (2021). Frequency of Eosinophilia in Patients with Bronchial Asthma in Khyber Pakhtunkhwa. Pakistan Journal of Chest Medicine, 27(3), 117-120.
https://www.pjcm.net/index.php/pjcm/article/view/722
13. Ramaswamy, L., Mahilmaran, A., Vignesh, D., & Hariprasad, S. (2023). PREVALENCE AND PREDICTORS OF EOSINOPHILIC ASTHMA IN OUT-PATIENT DEPARTMENTS IN A TERTIARY CARE CENTRE–A HOSPITAL RECORD-BASED STUDY. Int J Acad Med Pharm, 5(5), 779-784.
14. Ranjan, S. R., Kumar, B. S., Sasmita, M., & Kumar, M. B. (2023). A STUDY ON FREQUENCY OF EOSINOPHILIA IN PATIENTS WITH BRONCHIAL ASTHMA IN A TERTIARY CARE HOSPITAL IN WESTERN ODISHA. Int J Acad Med Pharm, 5(5), 313-315.
15. AWOPEJU, O. F., AWE, A., OGUNTOYE, O., AWOPEJU, I., ASAOLU, P., & SALAWU, L. (2025). Eosinophilic asthma according to blood eosinophil count in Nigerian adults with asthma: A single center cross-sectional study. Asthma Allergy Immunology, 136-144.
https://doi.org/10.21911/aai.2025.774
16. Ali, M. A. (2018-2019). The frequency of eosinophilia in asthmatic hospitalized patients. Research Project, Al-Nahrain University College of Medicine.
https://www.colmed-alnahrain.edu.iq/upload/res/896.pdf
17. Siddiqui, M. H., Baloch, A. A., Qasim, A., Bashir, B., & us Salam, J. (2014). Correlation between clinical severity and eosinophil count in asthmatic patients. Med Forum, 25(2), 31-32.
https://medicalforummonthly.com/index.php/mfm/article/view/1803
18. Mufarih Shah, D. M. (2024). Frequency of raised total serum ig E, sputum eosinophilia and blood eosinophil count in patients with severe persistent asthma. Journal of Population Therapeutics & Clinical Pharmacology, 36(6), 2101-2117.
https://doi.org/10.53555/jptcp.v31i6.6828
19. Qaiser, S., Saqib, M., & Mahmud, T. (2021). Frequency of raised total serum Ig E, sputum eosinophilia and blood eosinophil count in patients with severe persistent asthma. Proceedings, 35(1), 23-26.
https://doi.org/10.47489/p000s351z7791-4mc
20. BUTT, K., OMAR, A., HAMID, S., & JAWWAD, G. Effect of Inhaled Corticosteroids and Oral Montelukast on Frequency of high Eosinophil count in poorly controlled Asthmatic patient. Pak J Med Health Sci, 14(1), 561-563.
21. Vishnu Trinath, K. A. (2023). Correlation of sputum and peripheral eosinophil count in assessing the clinical severity in bronchial asthma. International Journal of Science and Research (IJSR), 12(5), 535-544.
https://doi.org/10.21275/sr23505135902
22. Kumar, N., Bylappa, K., Ramesh, A. C., & Reddy, S. (2012). A study of eosinophil count in nasal and blood smear in allergic respiratory diseases in a rural setup. Internet Journal of Medical Update-EJOURNAL, 7(1).
https://doi.org/10.4314/ijmu.v7i1
23. Issa, H. Y., Ramadhan, A. A., Safo, A. S., & Al Habib, O. A. (2020). Relationship between pulmonary function tests, sputum eosinophilia and total serum Ige levels among asthmatic patients in Duhok, Iraq. International Journal of Research in Medical Sciences, 8(6), 2033.
https://doi.org/10.18203/2320-6012.ijrms20202239
24. Fayezi, A., Torabizadeh, M., Masoomi, N., Abolnezhadian, F., Alisamir, M., Mirkarimi, M., & Bahadoram, M. (2021). Blood eosinophil count and bronchodilator responsiveness in pediatric patients admitted for wheezing attacks. Immunopathologia Persa.
https://doi.org/10.34172/ipp.2022.29298
25. Mathur, S., Corbridge, T., Packnett, E., Jariwala-Parikh, K., & Deb, A. (2024). Eosinophil count testing in patients with asthma varies by healthcare provider type in the US: A retrospective study. Allergy, Asthma & Clinical Immunology, 20(1).
https://doi.org/10.1186/s13223-024-00917-4
26. Marra, A., Rossi, C., Piga, M., Moroncini, G., & Bilò, M. (2024). Eosinophil-associated diseases: The allergist's and clinical immunologist's perspective. European Annals of Allergy and Clinical Immunology, 56(05), 195.
https://doi.org/10.23822/eurannaci.1764-1489.339
27. Butt, N. M., Lambert, J., Ali, S., Beer, P. A., Cross, N. C., Duncombe, A., Ewing, J., Harrison, C. N., Knapper, S., McLornan, D., Mead, A. J., Radia, D., & Bain, B. J. (2017). Guideline for the investigation and management of eosinophilia. British Journal of Haematology, 176(4), 553-572.
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