Microbiological Investigations of Girardinia palmata (Forssk.) Gaudich. as a Potential Antimicrobial Agent Against MDR Pathogens

Maryum Khan; Aqsa Nawaz; Sabah Mansoor; Muhammad Shahzad; Manzoor Hussain; Abdul Moeez Qureshi; Nauman Ahmad; Kashmala Ali

doi:10.70749/ijbr.v3i10.2401

Authors

Maryum Khan Department of Botany, Hazara University, Mansehra, KP, Pakistan.
Aqsa Nawaz Department of Plant Pathology, University of the Punjab, Lahore, Punjab, Pakistan.
Sabah Mansoor Institute of Biochemistry and Biotechnology, University of Veterinary and Animal Sciences, Lahore, Punjab, Pakistan.
Muhammad Shahzad Faculty of Pharmacy, Gomal University, Dera Ismail Khan, KP, Pakistan.
Manzoor Hussain Department of Botany, Hazara University, Mansehra, KP, Pakistan.
Abdul Moeez Qureshi Department of Microbiology, Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Punjab, Pakistan.
Nauman Ahmad Department of Microbiology, Lahore Garrison University, Lahore, Punjab, Pakistan.
Kashmala Ali Department of Zoology, Shaheed Benazir Bhutto Women University, Peshawar, KP, Pakistan.

DOI:

https://doi.org/10.70749/ijbr.v3i10.2401

Keywords:

Girardinia palmata, antimicrobial activity, multi-drug resistant pathogens, phytochemical screening, ethnopharmacology

Abstract

The use of natural products isolated from plants against infection, cancer diseases and other oxidative-stress-related diseases is one of the cornerstones of modern medicine. Therefore, we tried to establish a combination of medicinal plants for the development of antibacterial agents against these MDR strains. The aim of the research was to understand the Pharmacognostic features of dried stem, leaves and roots of Girardinia palmata (Forssk) Gaudich. Further antibacterial activity of Plant Girardinia palmata (Forssk) Gaudich. against MDR strains was determined via agar well diffusion assay. All experiments were conducted in triplicate. The results showed that the plant extract were shown to have zones of inhibition from 6 mm to 26 mm against multidrug-resistant pathogens such as Acinetobacter baumannii, Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumonia, Proteus mirabilis, Staphylococcus epidermidis and Salmonella typhi. The plant composites were active against most of the tested microorganisms. Hence, the present study suggested the possibility of employing compounds present in plant for the development of new antibacterial agents, as well as efflux pump inhibitors. The results showed that the Plant extract were have zones of inhibition from 6mm to 26mm against multidrug-resistant pathogens such as Acinetobacter baumannii, Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumonia, Proteus mirabilis, Salmonella typhi and Staphylococcus epidermidis. This study can be used as an effective tool for the authentication and identification of this plant. Further research should be done for the possibility of employing compounds present in plants for the development of new antibacterial agents, as well as efflux pump inhibitors.

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