Design, Synthesis, Molecular Docking, and Pharmacological Evaluation of 2-Aminobenzimidazole Derivatives as Potential Anti-Alzheimer’s Agents
DOI:
https://doi.org/10.70749/ijbr.v3i10.2451Abstract
Some new aminobenzimidazole derivatives were synthesized and investigated their pharmacological potential including anti-oxidant and acetylcholinesterase inhibitory activity to treat AD. A series of eight benzimidazole derivatives was synthesized by two-step procedure. All the synthesized derivatives were characterized by spectroscopic techniques such as NMR (1H-NMR) and FTIR. All the compounds were further evaluated for their anti-oxidant and AchE inhibitory potential. Four compounds 2g, 2a and 2b have shown potent inhibitory activity as 91.86%, 88.69%, and 81.91% respectively. Among eight synthesized compounds, the highest anti-oxidant activity 86.64% was exhibited by compound 2d, and compound 2d showed higher potency with IC50 of 4.96 µg/mL. Next docking studies were performed by using Auto Dock Vina program for which acetylcholinesterase has been used as target. Compounds 2e, 2a and 2d have exhibited the highest binding affinity with acetylcholinesterase among the synthesized derivatives with a value of -10.5 kcal/mol, -10.4 kcal/mol and -10.3 kcal/mol respectively. The results indicated that benzimidazole derivatives could be used as lead molecules for acetylcholinesterase inhibitors and can be further evaluated for their therapeutic potential for the treatment of AD.
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