Exploring the Role of Nanotechnology in Targeted Drug Delivery for the Control of Postoperative Inflammation and Promotion of the Surgical Recovery

Zarina Naz; Mohsin Raza; Momina Shahid; Hassan Ameen; Urwa Eiman; Sahaab Alvi

doi:10.70749/ijbr.v3i10.2542

Authors

Zarina Naz National University of Medical Sciences, Rawalpindi, Pakistan.
Mohsin Raza Department of Natural Compounds, Pharmaceutical and Medicinal Chemistry, The National Research Tomsk State University, Tomsk, Russian Federation.
Momina Shahid University of the Punjab, Lahore, Pakistan.
Hassan Ameen Institute of Molecular Biology and Biotechnology, Bahauddin Zakaria University, Multan, Pakistan.
Urwa Eiman Foundation University Medical College, Islamabad, Pakistan.
Sahaab Alvi Biosytomaics, Houston, Texas, USA.

DOI:

https://doi.org/10.70749/ijbr.v3i10.2542

Keywords:

Nanotechnology, Targeted Drug Delivery, Postoperative Inflammation, Wound Healing, Surgical Recovery, Nanocarriers, Controlled Release, Tissue Regeneration.

Abstract

This study explores the role of nanotechnology-based targeted drug delivery in controlling postoperative inflammation and enhancing surgical recovery. Traditional anti-inflammatory approaches often suffer from systemic toxicity and poor localization, whereas nanoscale carriers such as liposomes, polymeric nanoparticles, and dendrimers enable precise, sustained, and site-specific therapeutic release. Quantitative analysis of 200 postoperative patients revealed that 46% experienced minimal inflammation (mean CRP = 4.2 mg/L) and 27% showed only mild responses, demonstrating superior inflammatory control compared to conventional treatments. Moreover, 70% of patients treated with nanocarrier-mediated systems achieved rapid wound healing within 5–10 days, supported by accelerated epithelialization, reduced edema, and minimal infection risk. Overall, 72% exhibited excellent or good recovery, characterized by early mobility, minimal pain, and shorter hospital stays. These findings confirm that nanotechnology enhances drug bioavailability, modulates cytokine activity, promotes tissue regeneration, and significantly improves postoperative outcomes. Therefore, nanotechnology-based targeted delivery represents a safer and more effective therapeutic paradigm for postoperative care and surgical rehabilitation.

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