Safety and Efficacy of Microneedling Procedure in Treating Warts: Retrospective Analysis
DOI:
https://doi.org/10.70749/ijbr.v2i02.267Keywords:
Human Papilloma Virus, Warts, Warts Treatment, Micro NeedlingAbstract
Introduction: Warts are one of the most prevalent viral disorders that affect epidermal keratinocytes and are cutaneous signs of human papilloma virus infection. Warts are usually slow-growing and self-limiting, but treatment is required because of the possibility of transmission, aesthetic effect of the warts, psychological impact, excruciating pain, and disfiguring effects. Methodology: This was a retrospective analysis of 130 patients with warts to determine the effectiveness and safety of the needling procedure and the factors that could affect the outcomes. Results: In total, 130 patients were included in this study. Females made the major section (70.8%) of the study population, and the mean age of the study sample was 24.14 ± 5.9 years. The number of lesions ranged from single to 75. Time for the warts being symptomatic to present to clinic was 1 to 15 weeks, and 16.9% patients had pain when they presented to clinic. The sole (33.8%) and toes (17.7%) of feet were the most common sites of warts. The duration for which the patient had been symptomatic and the symptom of pain at presentation were significant factors for healing (p < 0.05). Conclusion: Needling procedures are still effective method for treating warts; in our study, 64.62% participants out of 130 showed improvement at certain level. Person perception and patient satisfaction were subjective.
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Muhammed-Ameen, D., & Meran, A. (2022). Topical Imiquimod 5% Cream Versus Salicylic acid 30% Cream in Treating Common Warts: A comparative study. Iraqi Journal of Pharmacy, 19(1), 65-79. https://www.iasj.net/iasj/download/9a3f5245d1c16da3
Nasr, M., Mohamed, S., & Elkholy, B. M. (2022). New Lines in the Treatment of multiple Warts: Review Article. The Egyptian Journal of Hospital Medicine, 88(1), 3990–3993. https://doi.org/10.21608/ejhm.2022.254073
Nofal, A., Abd Elmonsef, E. R., & Elkholy, B. M. (2022). An Overview of Various Lines in The Treatment of Warts: Review Article. The Egyptian Journal of Hospital Medicine, 86(1), 570–573. https://doi.org/10.21608/ejhm.2022.215111
Zhu, P., Qi, R., Yang, Y., Huo, W., Zhang, Y., He, L., Wang, G., Xu, J., Zhang, F., Yang, R., Tu, P., Ma, L., Liu, Q., Li, Y., Gu, H., Cheng, B., Chen, X., Chen, A., Xiao, S., & Jin, H. (2022). Clinical guideline for the diagnosis and treatment of cutaneous warts (2022). Journal of Evidence-Based Medicine, 15(3), 284–301. https://doi.org/10.1111/jebm.12494
Torres, S. P., Rupprecht, C., Relangi, S., Rana, D., & Krishnaswamy, G. (2023). AMELIORATION OF SEVERE EXTRAGENITAL WARTS USING HPV VACCINATION: CASE REPORT AND SURVEY OF THE LITERATURE. Annals of Allergy, Asthma & Immunology, 131(5), S191–S192. https://doi.org/10.1016/j.anai.2023.08.590
Mayakuntla, B., Meda, S., Ravi, S. S., Indira, B., Anitha, V., & Satyanarayana, V. V. V. (2023). Intralesional acyclovir in the treatment of cutaneous warts: A novel therapeutic approach. Journal of Pakistan Association of Dermatologists, 33(2), 495-498. https://jpad.com.pk/index.php/jpad/article/view/2151
Kumar, S., Kaur, N., Brar, B., Bano, R., Boparai, A., & Gill, S. (2022). A comparative evaluation of therapeutic efficacy and safety of Falknor’s needling versus autoimplantation in cutaneous warts. National Journal of Physiology Pharmacy and Pharmacology, 0, 1–1. https://doi.org/10.5455/njppp.2023.13.09419202214092022
Truong, K., Joseph, J., Manago, B., & Wain, T. (2022). Destructive therapies for cutaneous warts: A review of the evidence. Australian Journal of General Practice, 51(10), 799–803. https://doi.org/10.31128/ajgp-01-22-6305
Chen, J., Ren, H., Zhou, P., Zheng, S., Du, B., Liu, X., & Xiao, F. (2022). Microneedle-mediated drug delivery for cutaneous diseases. Frontiers in Bioengineering and Biotechnology, 10. https://doi.org/10.3389/fbioe.2022.1032041
Devi, K., Intaran, A., Made, L., Rusyati, M., & Sadeli, M. (2022). Current Treatment Options for Cutaneous and Plantar Warts: A Literature Review and Update Corresponding Author: 2*. Teikyo Medical Journal, 45. https://www.teikyomedicaljournal.com/volume/TMJ/45/05/current-treatment-options-for-cutaneous-and-plantar-warts-a-literature-review-and-update-62bd2c88aac74.pdf
Witchey, D. J., Witchey, N. B., Roth-Kauffman, M. M., & Kauffman, M. K. (2018). Plantar Warts: Epidemiology, Pathophysiology, and Clinical Management. The Journal of the American Osteopathic Association, 118(2), 92. https://doi.org/10.7556/jaoa.2018.024
Silverberg, N. B. (2019). Pediatric warts: update on interventions. PubMed, 103(1), 26;27;28;29;30;E2;E3;E4–26;27;28;29;30;E2;E3;E4. https://pubmed.ncbi.nlm.nih.gov/30758340/
Hekmatjah, J., Farshchian, M., Grant-Kels, J. M., & Mehregan, D. (2021). The status of treatment for plantar warts in 2021: No definitive advancements in decades for a common dermatology disease. Clinics in Dermatology, 39(4), 688–694. https://doi.org/10.1016/j.clindermatol.2021.05.024
Winterton, S., & Daly, S. (2018). What is the best treatment for plantar warts? Evidence-Based Practice, 21(6), 12. https://doi.org/10.1097/01.ebp.0000545158.92446.cd
Saaiq, M. (2023). Clinical epidemiology and management outcome of non-genital cutaneous viral warts. Mirpur Journal of Medical Sciences, 1(1), 3-8. https://mjms.org.pk/index.php/mjms/article/view/3
Bar‐Ilan, E., Bar, J., Baniel, A., Slodownik, D., Artzi, O., Samuelov, L., Sprecher, E., & Mashiah, J. (2023). Intralesional human papillomavirus vaccine for the treatment of recalcitrant cutaneous warts. The Journal of Dermatology, 50(11), 1373–1380. https://doi.org/10.1111/1346-8138.16905
Abdel Meguid, A. M., Abdel Motaleb, A. A., & Abdel Sadek, A. M. I. (2018). Cryotherapy vs trichloroacetic acid 90% in treatment of common warts. Journal of Cosmetic Dermatology, 18(2), 608–613. https://doi.org/10.1111/jocd.12805
Nuccitelli, R., LaTowsky, B. M., Lain, E., Munavalli, G., Loss, L., Ross, E. V., Jauregui, L., & Knape, W. A. (2021). Safety and Efficacy of Nano‐Pulse Stimulation Treatment of Non‐Genital, Cutaneous Warts (Verrucae). Lasers in Surgery and Medicine, 53(10), 1301–1306. https://doi.org/10.1002/lsm.23423
Bristow, I., Lim, W. C., Lee, A., Holbrook, D., Savelyeva, N., Thomson, P., Webb, C., Polak, M., & Ardern-Jones, M. R. (2017). Microwave therapy for cutaneous human papilloma virus infection. European Journal of Dermatology, 27(5), 511–518. https://doi.org/10.1684/ejd.2017.3086
Gamil, H. D., Nasr, M. M., Khattab, F. M., & Ibrahim, A. M. (2020). Combined therapy of plantar warts with topical bleomycin and microneedling: a comparative controlled study. The Journal of Dermatological Treatment, 31(3), 235–240. https://doi.org/10.1080/09546634.2019.1612837
Marahatta, S., Khadka, D. K., Agrawal, S., & Rijal, A. (2021). Intralesional Bleomycin for the Treatment of Resistant Palmoplantar and Periungual Warts. Dermatology Research and Practice, 2021, 1–6. https://doi.org/10.1155/2021/8655004
Mohta, A., Chand Ghiya, B., Dutt Mehta, R., Soni, P., Khokhar, R., Sharda, P., & Ranga, Z. (2021). Skin needling with 100% trichloroacetic acid vs. needling with bleomycin in the treatment of recalcitrant cutaneous warts. Clinical and Experimental Dermatology. https://doi.org/10.1111/ced.14968
Redzic, N., Benoy, I., Vanden Broeck, D., & Bogers, Johannes. P. (2020). Efficacy of AV2-Salicylic acid combination therapy for cutaneous warts: Study protocol for a single-center randomized controlled trial. Contemporary Clinical Trials Communications, 17, 100534. https://doi.org/10.1016/j.conctc.2020.100534 .
Soenjoyo, K. R., Chua, B. W. B., Wee, L. W. Y., Koh, M. J. A., & Ang, S. B. (2020). Treatment of cutaneous viral warts in children: A review. Dermatologic Therapy. https://doi.org/10.1111/dth.14034 .
Vakharia, P. P., Chopra, R., Silverberg, N. B., & Silverberg, J. I. (2018). Efficacy and Safety of Topical Cantharidin Treatment for Molluscum Contagiosum and Warts: A Systematic Review. American Journal of Clinical Dermatology, 19(6), 791–803. https://doi.org/10.1007/s40257-018-0375-4
Rijsbergen, M., Niemeyer‐van der Kolk, T., Hogendoorn, G., Kouwenhoven, S., Lemoine, C., Klaassen, E. S., de Koning, M., Beck, S., Bouwes Bavinck, J. N., Feiss, G., Burggraaf, J., & Rissmann, R. (2019). A randomized controlled proof‐of‐concept trial of digoxin and furosemide in adults with cutaneous warts. British Journal of Dermatology, 180(5), 1058–1068. https://doi.org/10.1111/bjd.17583
Gerodimou, M., Gerochristou, M., Emmanouil, G., Douvali, T., & Mazioti, M. (2020). Efficacy of topical 85% formic acid solution in the treatment of warts. Our Dermatology Online, 11(4), 363–366. https://doi.org/10.7241/ourd.20204.7
Yadav, D., Kumari, P., Vijay, A., Jain, S., Kumar, M., Kumar, R., & Nyati, A. (2018). Falknor’s needling method as a potential immunotherapy in palmo-plantar warts. Indian Journal of Dermatology, Venereology and Leprology, 0(0), 0. https://doi.org/10.4103/ijdvl.ijdvl_809_17
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