Frequency and Gender Differences of Non Motor Symptoms in Patients with Parkinson’s Disease; A Cross Sectional Study
DOI:
https://doi.org/10.70749/ijbr.v3i7.2814Keywords:
Parkinson’s Disease, Non Motor Symptoms, Frequency and Gender Differences.Abstract
Background: Parkinson’s disease is one of the most common neurodegenerative disorder, presenting with a variety of symptoms. Objective: To determine Frequencies and gender differences of Non Motor symptoms among patients presenting with Parkinson’s disease to Tertiary Care Hospital of Lahore. Methodology: This cross sectional study was conducted at the department of Neurology, National Hospital and Medical Center, Lahore, from, December 2024 to May 2025. A total of 185 patients presenting with Parkinson’s disease in the neurology department were included through non-probability consecutive sampling. Individuals of both genders aged 30 to 90 years were enrolled after obtaining informed consent. Results: Out of 185 patients, 137(74.1%) were male and 48(25.9%) were female .The mean age was 63.6±7.3 years. The majority of patients (59.5%) were within the 61-70 year age group. Across both genders, the most common symptoms were fatigue and urinary problems(65.9%).Among females, the most common symptom was depression (85.4%), while males predominantly experienced fatigue (62.8%). Conclusion: It is concluded that Parkinson's disease was more prevalent in men, and majority of patients suffered from non motor symptoms, with fatigue and urinary problems as the most commonly reported symptoms overall. However, females experienced a higher burden of mood disorders and pain.
Downloads
References
1. Armstrong, M. J., & Okun, M. S. (2020). Diagnosis and treatment of Parkinson disease. JAMA, 323(6), 548.
https://doi.org/10.1001/jama.2019.22360
2. Lew, M. (2007). Overview of Parkinson's disease. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 27(12P2).
https://doi.org/10.1592/phco.27.12part2.155s
3. Miller, I. N., & Cronin‐Golomb, A. (2010). Gender differences in Parkinson's disease: Clinical characteristics and cognition. Movement Disorders, 25(16), 2695-2703.
https://doi.org/10.1002/mds.23388
4. Schapira, A. H., Chaudhuri, K. R., & Jenner, P. (2017). Non-motor features of Parkinson disease. Nature Reviews Neuroscience, 18(7), 435-450.
https://doi.org/10.1038/nrn.2017.62
5. World Health Organization. (2023, August 9). Parkinson disease. World Health Organization.
https://www.who.int/news-room/fact-sheets/detail/parkinson-disease
6. Cacabelos, R. (2017). Parkinson’s disease: From pathogenesis to Pharmacogenomics. International Journal of Molecular Sciences, 18(3), 551.
https://doi.org/10.3390/ijms18030551
7. Dean, A. G. (2010). OpenEpi: open source epidemiologic statistics for public health, version 2.3. 1.
8. Growdon JH, Corkin S, Rosen TJ. Distinctive patterns of cognitive loss in Parkinson's disease. Adv Neurol. 1990;53:139-43.
9. Postuma, R. B., Berg, D., Stern, M., Poewe, W., Olanow, C. W., Oertel, W., Obeso, J., Marek, K., Litvan, I., Lang, A. E., Halliday, G., Goetz, C. G., Gasser, T., Dubois, B., Chan, P., Bloem, B. R., Adler, C. H., & Deuschl, G. (2015). MDS clinical diagnostic criteria for Parkinson's disease. Movement Disorders, 30(12), 1591-1601.
https://doi.org/10.1002/mds.26424
10. Zirra, A., Rao, S. C., Bestwick, J., Rajalingam, R., Marras, C., Blauwendraat, C., Mata, I. F., & Noyce, A. J. (2022). Gender differences in the prevalence of Parkinson's disease. Movement Disorders Clinical Practice, 10(1), 86-93.
https://doi.org/10.1002/mdc3.13584
11. Hussain W, Bashir F, Naeem A, et al. Epidemiological distribution of Parkinson disease by age and gender in Pakistan: a population-based approach. ResearchGate; 2025.
12. Luo, Y., Qiao, L., Li, M., Wen, X., Zhang, W., & Li, X. (2025). Global, regional, national epidemiology and trends of Parkinson’s disease from 1990 to 2021: Findings from the global burden of disease study 2021. Frontiers in Aging Neuroscience, 16.
https://doi.org/10.3389/fnagi.2024.1498756
13. Haaxma, C. A., Bloem, B. R., Borm, G. F., Oyen, W. J., Leenders, K. L., Eshuis, S., Booij, J., Dluzen, D. E., & Horstink, M. W. (2007). Gender differences in Parkinson's disease. Journal of Neurology, Neurosurgery & Psychiatry, 78(8), 819-824.
https://doi.org/10.1136/jnnp.2006.103788
14. Barone, P., Antonini, A., Colosimo, C., Marconi, R., Morgante, L., Avarello, T. P., Bottacchi, E., Cannas, A., Ceravolo, G., Ceravolo, R., Cicarelli, G., Gaglio, R. M., Giglia, R. M., Iemolo, F., Manfredi, M., Meco, G., Nicoletti, A., Pederzoli, M., Petrone, A., … Dotto, P. D. (2009). The PRIAMO study: A multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson's disease. Movement Disorders, 24(11), 1641-1649.
https://doi.org/10.1002/mds.22643
15. Fernandes, M., Pierantozzi, M., Stefani, A., Cattaneo, C., Bonizzoni, E. A., Cerroni, R., Mercuri, N. B., & Liguori, C. (2021). Frequency of non-motor symptoms in Parkinson's patients with motor fluctuations. Frontiers in Neurology, 12.
https://doi.org/10.3389/fneur.2021.678373
16. Martinez-Martin, P., Falup Pecurariu, C., Odin, P., van Hilten, J. J., Antonini, A., Rojo-Abuin, J. M., ... & Ray Chaudhuri, K. (2012). Gender-related differences in the burden of non-motor symptoms in Parkinson’s disease. Journal of neurology, 259(8), 1639-1647.
https://doi.org/10.1007/s00415-011-6392-3
17. Nicoletti A, Rodriguez-Blazquez C, Vasta R, Mostile G, Lucas-del-Pozo S, Quintana S, et al. Gender, mood and quality of life in Parkinson's disease. J Psychosom Res. 2017 Aug;99:60-65.
18. Picillo M, Nicoletti A. Gender differences in non-motor symptoms in Parkinson's disease. Curr Opin Neurol. 2013 Aug;26(4):391-6.
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Indus Journal of Bioscience Research

This work is licensed under a Creative Commons Attribution 4.0 International License.