Enhanced Fluoride Release from Glass Ionomer Cements and Compomers Modified with Clove Oil and Thymol: A Step Toward Advanced Caries Prevention
DOI:
https://doi.org/10.70749/ijbr.v3i1.285Keywords:
Fluoride Release, Glass Ionomer Cements (GICs), Natural Additives, Dental Caries PreventionAbstract
Dental caries, a prevalent global health issue, significantly impacts oral health and quality of life. Glass ionomer cements (GICs) and compomers, valued for their fluoride-releasing properties, are pivotal in caries prevention and management. This study explores the enhancement of fluoride release from GICs and compomers modified with natural additives—clove oil and thymol—at varying concentrations (0.5%, 1%, 2%). These additives, known for their bioactive and antimicrobial properties, were incorporated into the dental materials, and fluoride release was measured over 30 days. Disc-shaped specimens were fabricated, standardized, and tested for fluoride ion release at predetermined intervals (Days 1, 7, 14, 30) using an ion-selective electrode. Results revealed that modified materials exhibited significantly higher fluoride release compared to unmodified controls. The 2% clove oil and thymol-modified samples demonstrated the greatest cumulative fluoride release, with a dose-dependent effect observed across concentrations. Statistical analysis confirmed significant differences (p < 0.05) between control and modified groups, indicating that natural additives enhance fluoride release properties effectively. The findings underscore the potential of clove oil and thymol in improving the therapeutic efficacy of dental materials, with implications for sustained caries prevention. By combining fluoride delivery with the bioactive benefits of natural additives, this study provides a pathway for developing advanced restorative materials to address oral health disparities, especially in high-risk populations. Future research should focus on optimizing these materials for broader clinical application, ensuring enhanced fluoride release without compromising structural and functional integrity.
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Spatafora, G., Li, Y., He, X., Cowan, A., & Tanner, A. C. R. (2024). The Evolving Microbiome of Dental Caries. Microorganisms, 12(1), 121. https://doi.org/10.3390/microorganisms12010121
Heilmann, A., & Watt, R. G. (2024). Strategic public health considerations for caries control in populations. Dental Caries: The Disease and its Clinical Management, 17.
Dimopoulou, M., Antoniadou, M., Amargianitakis, M., Gortzi, O., Androutsos, O., & Varzakas, T. (2023). Nutritional Factors Associated with Dental Caries across the Lifespan: A Review. Applied Sciences, 13(24), 13254. https://doi.org/10.3390/app132413254
Goodwin, M., Henshaw, M., & Borrelli, B. (2023). Inequities and oral health: A behavioural sciences perspective. Community Dentistry and Oral Epidemiology, 51(1), 108–115. https://doi.org/10.1111/cdoe.12826
Allison, P. (2024). Social Determinants of Oral Health: A Comprehensive Review of Socioeconomic and Environmental Factors. Journal of dental care, 1(1), 1-10.
Zhu, T., Huang, Z., Shu, X., Zhang, C., Dong, Z., & Peng, Q. (2022). Functional nanomaterials and their potentials in antibacterial treatment of dental caries. Colloids and Surfaces B: Biointerfaces, 218, 112761. https://doi.org/10.1016/j.colsurfb.2022.112761
Adeghe, P. (2024). The multifaceted role of fluoride in preventing early childhood caries: A comprehensive review. International Journal of Life Science Research Updates, 2(1), 009-017. https://doi.org/10.53430/ijlsru.2024.2.1.0022
Rodriguez-Justo, M., Khadatkar, P., Suresh, S., Arisutha, S., & Verma, S. (2021). Fluorides-foundation for healthy teeth: a dental perspectives. Journal of Sol-Gel Science and Technology, 100(3), 375–387. https://doi.org/10.1007/s10971-021-05668-x
Veiga, N., Carvalho, R., Correia, P., Lopes, P., Couto, P., & Vicentis, G. (2023). Methods of Primary Clinical Prevention of Dental Caries in the Adult Patient: An Integrative Review. Healthcare, 11(11), 1635–1635. https://doi.org/10.3390/healthcare11111635
Motallaei, M. N., Yazdanian, M., Tebyanian, H., Tahmasebi, E., Alam, M., Abbasi, K., Seifalian, A., Ranjbar, R., & Yazdanian, A. (2021). The Current Strategies in Controlling Oral Diseases by Herbal and Chemical Materials. Evidence-Based Complementary and Alternative Medicine, 2021, 1–22. https://doi.org/10.1155/2021/3423001
Ivica, A., Šalinović, I., Krmek, S. J., Garoushi, S., Lassila, L., Säilynoja, E., & Miletić, I. (2024). Mechanical Properties and Ion Release from Fibre-Reinforced Glass Ionomer Cement. Polymers, 16(5), 607–607. https://doi.org/10.3390/polym16050607
Maloo, L. M., Patel, A., Toshniwal, S. H., & Bagde, A. D. (2022). Smart Materials Leading to Restorative Dentistry: An Overview. Cureus, 14(10). https://doi.org/10.7759/cureus.30789
Saridena, U. S. N. G., Sanka, G. S. S. J., Alla, R. K., AV, R., MC, S. S., & Raju Mantena, S. (2022). An overview of advances in glass ionomer cements. International Journal of Dental Materials, 04(04), 89–94. https://doi.org/10.37983/ijdm.2022.4403
Yu, O. Y., Ge, K. X., Lung, C. Y.-K., & Chu, C.-H. (2024). Developing a novel glass ionomer cement with enhanced mechanical and chemical properties. Dental Materials, 40(7), e1–e13. https://doi.org/10.1016/j.dental.2024.05.019
Yang, Q., Li, F., Ye, Y., & Zhang, X. (2024). Antimicrobial, remineralization, and infiltration: advanced strategies for interrupting dental caries. Medical Review, 0(0). https://doi.org/10.1515/mr-2024-0035
Alzebiani, N. (2023). Ability of Experimental Resin Modified Glass Ionomer Cements (RMGICs) to Remineralise and Form Apatite on Immersion (Doctoral dissertation, Queen Mary University of London).
Tokarczuk, D., Tokarczuk, O., Kiryk, J., Kensy, J., Szablińska, M., Dyl, T., Dobrzyński, W., Matys, J., & Dobrzyński, M. (2024). Fluoride Release by Restorative Materials after the Application of Surface Coating Agents: A Systematic Review. Applied Sciences, 14(11), 4956–4956. https://doi.org/10.3390/app14114956
Sikka, N., & Brizuela, M. (2024). Glass ionomer cement. StatPearls.
Pani, P. (2022). PIT AND FISSURE SEALANTS THE STOP OF THE DEMON. Book Rivers.
de, R., Jurado-Davila, I. V., Toffoli, J., Guerra, K., Estumano, D. C., Robson, Carissimi, E., & Féris, L. A. (2024). Exploring Key Parameters in Adsorption for Effective Fluoride Removal: A Comprehensive Review and Engineering Implications. Applied Sciences (Basel), 14(5), 2161–2161. https://doi.org/10.3390/app14052161
Sherief, D. I., Fathi, M. S., & El, A. (2020). Antimicrobial properties, compressive strength and fluoride release capacity of essential oil-modified glass ionomer cements—an in vitro study. Clinical Oral Investigations, 25(4), 1879–1888. https://doi.org/10.1007/s00784-020-03493-0
Center, B. D. (2023). Microleakage Among Different Dental Restorative Materials: Causes, Detection, and Impact on Marginal Integrity. https://johs.com.sa/admin/public/uploads/187/208_pdf.pdf
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