Diagnostic Accuracy of the Upper Lip Bite Test for Predicting Difficult Intubation: A Cross-Sectional Study
DOI:
https://doi.org/10.70749/ijbr.v4i2.2893Keywords:
Upper Lip Bite Test, Difficult Intubation, Airway Assessment, Cormack–Lehane Classification, Anesthesia.Abstract
Background: Unexpected difficult tracheal intubation remains a major cause of anesthesia-related morbidity and mortality worldwide. Accurate preoperative airway assessment is therefore essential to reduce airway-related complications. Several bedside airway tests are available; however, none has demonstrated ideal predictive accuracy across all patient populations. The Upper Lip Bite Test (ULBT) is a simple bedside test assessing mandibular mobility and dentition, and has shown promising diagnostic performance in previous studies. Methods: This cross-sectional diagnostic accuracy study was conducted at Patel Hospital, Karachi, from July 2022 to January 2025. A total of 231 adult patients aged 20–60 years undergoing elective surgery under general anesthesia with endotracheal intubation were enrolled using non-probability consecutive sampling. ULBT was performed preoperatively and classified into three grades. Direct laryngoscopy was performed after induction of anesthesia, and laryngeal view was graded using the Cormack–Lehane (C–L) classification, which served as the reference standard. Difficult laryngoscopy was defined as C–L grade IIb–IV. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and diagnostic accuracy were calculated. Results: Among 231 patients, 28 (12.1%) experienced difficult laryngoscopy. ULBT demonstrated a sensitivity of 85.7%, specificity of 98.0%, PPV of 92.3%, NPV of 96.0%, and an overall diagnostic accuracy of 95.2%. Conclusion: The Upper Lip Bite Test is a simple, rapid, and highly specific tool for predicting difficult laryngoscopy and can be effectively incorporated into routine pre-anesthetic airway assessment.
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1. Cook, T., Woodall, N., & Frerk, C. (2011). Major complications of airway management in the UK: Results of the fourth national audit project of the royal college of anaesthetists and the Difficult Airway Society. Part 1: Anaesthesia. British Journal of Anaesthesia, 106(5), 617-631.
https://doi.org/10.1093/bja/aer058
2. Apfelbaum, J. L., Hagberg, C. A., Caplan, R. A., Blitt, C. D., Connis, R. T., Nickinovich, D. G., ... & Ovassapian, A. (2013). Practice guidelines for management of the difficult airway: an updated report by the American Society of Anesthesiologists Task Force on Management of the Difficult Airway. Anesthesiology, 118(2), 251-270.
https://doi.org/10.1097/ALN.0b013e31827773b2
3. Shiga, T., Wajima, Z., Inoue, T., & Sakamoto, A. (2005). Predicting difficult intubation in apparently normal patients. Anesthesiology, 103(2), 429-437.
https://doi.org/10.1097/00000542-200508000-00027
4. Khan, Z. H., Kashfi, A., & Ebrahimkhani, E. (2003). A comparison of the upper lip bite test (a simple new technique) with modified Mallampati classification in predicting difficulty in endotracheal intubation: A prospective blinded study. Anesthesia & Analgesia, 96(2), 595-599.
https://doi.org/10.1213/00000539-200302000-00053
5. Hester, C. E., Dietrich, S. A., White, S. W., Secrest, J. A., Lindgren, K. R., & Smith, T. (2007). A comparison of preoperative airway assessment techniques: the modified Mallampati and the upper lip bite test. AANA journal, 75(3).
6. Cook, T. M. (2000). A new practical classification of laryngeal view. Anaesthesia, 55(3), 274-279.
https://doi.org/10.1046/j.1365-2044.2000.01270.x
7. Lundstrøm, L. H., Vester-Andersen, M., Møller, A. M., Charuluxananan, S., L'hermite, J., & Wetterslev, J. (2011). Poor prognostic value of the modified Mallampati score: a meta-analysis involving 177 088 patients. British journal of anaesthesia, 107(5), 659-667.
https://doi.org/10.1093/bja/aer292
8. Samsoon GL, Young JR. Difficult tracheal intubation: a retrospective study. Anaesthesia. 1987;42(5):487-490.
https://doi.org/10.1111/j.1365-2044.1987.tb04039.x.
9. Nørskov AK, Rosenstock CV, Wetterslev J, Lundstrøm LH. Diagnostic accuracy of airway assessment tests for predicting difficult intubation: a systematic review and meta-analysis. Br J Anaesth. 2016;116(3):297-308.
https://doi.org/10.1093/bja/aev404
10. WILSON, M., SPIEGELHALTER, D., ROBERTSON, J., & LESSER, P. (1988). Predicting difficult intubation. British Journal of Anaesthesia, 61(2), 211-216.
https://doi.org/10.1093/bja/61.2.211
11. El-Ganzouri, A. R., McCarthy, R. J., Tuman, K. J., Tanck, E. N., & Ivankovich, A. D. (1996). Preoperative airway assessment. Anesthesia & Analgesia, 82(6), 1197-1204.
https://doi.org/10.1213/00000539-199606000-00017
12. Rosenblatt WH, Sukhupragarn W. Airway management. Anesthesiol Clin. 2015;33(2):257-278.
https://doi.org/10.1016/j.anclin.2015.02.003
13. Healy DW, Maties O, Hovord D, Kheterpal S. A systematic review of the role of videolaryngoscopy in successful orotracheal intubation. Br J Anaesth. 2012;109(1):41-49.
https://doi.org/10.1093/bja/aes113
14. Langeron, O., Masso, E., Huraux, C., Guggiari, M., Bianchi, A., Coriat, P., & Riou, B. (2000). Prediction of difficult mask ventilation. Anesthesiology, 92(5), 1229-1236.
https://doi.org/10.1097/00000542-200005000-00009
15. Krobbuaban B, Diregpoke S, Kumkeaw S, Tanomsat M. The predictive value of the upper lip bite test for difficult intubation. J Med Assoc Thai. 2005;88(4):505-509.
https://pubmed.ncbi.nlm.nih.gov/15962687/
16. Badheka JP, Doshi PM, Vyas AM, Kacha NJ, Parmar VS. Comparison of upper lip bite test with modified Mallampati classification in predicting difficult intubation. Indian J Anaesth. 2010;54(5):400-405.
https://doi.org/10.4103/0019-5049.71033
17. Etezadi F, Ahangari A, Shokri H, Najafi A, Khajavi MR, Moharari RS. Upper lip bite test as a predictor of difficult intubation. Anesth Analg. 2013;116(4):885-889.
https://doi.org/10.1213/ANE.0b013e31827abf0d
18. Khan ZH, Arbabi S, Yekaninejad MS, Madadkhan M. Diagnostic value of the upper lip bite test in predicting difficult intubation. Eur J Anaesthesiol. 2009;26(10):817-821.
https://doi.org/10.1097/EJA.0b013e32832c4c4b
19. Prakash S, Mullick P, Bhandari S, Kumar A, Gogia AR, Singh R. Evaluation of airway predictors including upper lip bite test in obese patients. J Anaesthesiol Clin Pharmacol. 2018;34(3):395-401.
https://doi.org/10.4103/joacp.JOACP_154_17
20. Roth D, Pace NL, Lee A, Hovhannisyan K, Warenits AM, Arrich J, et al. Airway physical examination tests for detection of difficult airway management in apparently normal adult patients. Cochrane Database Syst Rev. 2018;5:CD008874.
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