Clinical Audit of Inpatient Insulin Prescribing Patterns and Glycemic Outcomes: Sliding Scale Insulin Versus Basal–Bolus Therapy

Authors

  • Sibte Abbas General Practitioner & Public Health Physician, Bassam Medical Center, NEOM, Saudi Arabia.
  • Faiqa Jamil Department of General Medicine, Hayatabad Medical Complex, Peshawar, KP, Pakistan.
  • Fatima tu Zuhra Department of General Medicine, Hayatabad Medical Complex, Peshawar, KP, Pakistan.
  • Tanveer Ahmad Department of Internal Medicine, Lady Reading Hospital, Peshawar, KP, Pakistan.
  • Ishfaq Ahmad Mohmand Department of Internal Medicine, Lady Reading Hospital, Peshawar, KP, Pakistan.
  • Mahnoor Durrani Jinnah Teaching Hospital, Peshawar, KP, Pakistan.
  • Muhammad Shoaib Department of Internal Medicine, Lady Reading Hospital, Peshawar, KP, Pakistan.

DOI:

https://doi.org/10.70749/ijbr.v4i4.3060

Keywords:

Inpatient Hyperglycemia, Sliding Scale Insulin, Basal–bolus Insulin, Glycemic Control, Clinical Audit, Hypoglycemia, Hospital Stay.

Abstract

Background: Inpatient hyperglycemia is associated with adverse clinical outcomes and requires effective management. Despite evidence favoring basal–bolus insulin (BBI) therapy, sliding scale insulin (SSI) remains widely used in many hospitals. Objective: To evaluate inpatient insulin prescribing patterns and compare glycemic outcomes between SSI and BBI therapy during a third audit cycle. Methods: TThis re-audit of clinical practices was carried out at Lady Reading Hospital between June and December 2025 The study evaluated 482 insulin-treated patients with hyperglycemia admitted to hospital. Insulin type, blood glucose (BG) control, hypoglycemia, length of stay (LOS) and mortality were reviewed. Comparisons between SSI and BBI were made using appropriate tests of significance (p ≤ 0.05). Results: 64% of patients received BBI while 36% of patients used SSI. BBI use was linked to improved glycemic control (average glucose 162 ±35 mg/dL vs. 198 ± 42 mg/dL), reduced hypoglycemia (6% vs. 15%) and shorter hospital stay (3.5 vs. 4.9 days) over SSI (p<0.05). BBI was associated with a lower (insignificant) mortality rate (2% vs. 4%). Conclusion: Basal–bolus insulin therapy demonstrates superior clinical outcomes compared to SSI. Sustained audit interventions effectively improved prescribing practices and patient outcomes.

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References

1. Korytkowski, M. T., Muniyappa, R., Antinori-Lent, K., Donihi, A. C., Drincic, A. T., Hirsch, I. B., Luger, A., McDonnell, M. E., Murad, M. H., Nielsen, C., Pegg, C., Rushakoff, R. J., Santesso, N., & Umpierrez, G. E. (2022). Management of hyperglycemia in hospitalized adult patients in non-critical care settings: An Endocrine Society clinical practice guideline. The Journal of Clinical Endocrinology & Metabolism, 107(8), 2101-2128.

https://doi.org/10.1210/clinem/dgac278

2. Dhatariya, K., & Umpierrez, G. E. (2024). Management of diabetes and hyperglycemia in hospitalized patients. Endotext [Internet].

https://www.ncbi.nlm.nih.gov/sites/books/NBK279093/

3. Barmanray, R. D., Kyi, M., Worth, L. J., Colman, P. G., Churilov, L., Fazio, T. N., Rayman, G., Gonzalez, V., Hall, C., & Fourlanos, S. (2024). Hyperglycemia in hospital: An independent marker of infection, acute kidney injury, and stroke for hospital inpatients. The Journal of Clinical Endocrinology & Metabolism, 109(11), e2048-e2056.

https://doi.org/10.1210/clinem/dgae051

4. Pratiwi, C., Zulkifly, S., Dahlan, T. F., Hafidzati, A., Oktavia, N., Mokoagow, M. I., Epriliawati, M., Nasarudin, J., & Made Kshanti, I. A. (2021). Hospital related hyperglycemia as a predictor of mortality in non-diabetes patients: A systematic review. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 15(6), 102309.

https://doi.org/10.1016/j.dsx.2021.102309

5. Demidowich, A. P., Stanback, C., & Zilbermint, M. (2024). Inpatient diabetes management. Annals of the New York Academy of Sciences, 1538(1), 5-20.

https://doi.org/10.1111/nyas.15190

6. Horton, W. B. (2023). Inpatient management of diabetes and hyperglycemia. The Diabetes Textbook, 739-753.

https://doi.org/10.1007/978-3-031-25519-9_46

7. Lam, K., Gan, S., Nguyen, B., Jing, B., & Lee, S. J. (2022). Sliding scale insulin use in a national cohort study of nursing home residents with type 2 diabetes. Journal of the American Geriatrics Society, 70(7), 2008-2018.

https://doi.org/10.1111/jgs.17771

8. Alex, M., Sreedharan, D. P., Bhandari, R., & Kolar, R. (2024). Retrospective analysis of sliding scale versus basal bolus insulin in the treatment of uncontrolled hyperglycemia in patients with type 2 diabetes mellitus and infections. International Journal of Diabetes in Developing Countries, 45(3), 661-669.

https://doi.org/10.1007/s13410-024-01397-3

9. Pasquel, F. J., Lansang, M. C., Dhatariya, K., & Umpierrez, G. E. (2021). Management of diabetes and hyperglycaemia in the hospital. The Lancet Diabetes & Endocrinology, 9(3), 174-188.

https://doi.org/10.1016/s2213-8587(20)30381-8

10. Seisa, M. O., Saadi, S., Nayfeh, T., Muthusamy, K., Shah, S. H., Firwana, M., Hasan, B., Jawaid, T., Abd-Rabu, R., Korytkowski, M. T., Muniyappa, R., Antinori-Lent, K., Donihi, A. C., Drincic, A. T., Luger, A., Torres Roldan, V. D., Urtecho, M., Wang, Z., & Murad, M. H. (2022). A systematic review supporting the Endocrine Society clinical practice guideline for the management of hyperglycemia in adults hospitalized for Noncritical illness or undergoing elective surgical procedures. The Journal of Clinical Endocrinology & Metabolism, 107(8), 2139-2147.

https://doi.org/10.1210/clinem/dgac277

11. Lai, J., Li, Q., He, Y., Zou, S., Bai, X., & Rastogi, S. (2022). Glycemic control regimens in the prevention of surgical site infections: A meta-analysis of randomized clinical trials. Frontiers in Surgery, 9.

https://doi.org/10.3389/fsurg.2022.855409

12. Passarella, P., & Gosmanov, A. R. (2026). Insulin therapy. Medical Clinics of North America, 110(3), 363-375.

https://doi.org/10.1016/j.mcna.2025.11.001

13. Chawla, R., Mukherjee, J. J., Chawla, M., Kanungo, A., Shunmugavelu, M. S., & Das, A. K. (2021). Expert group recommendations on the effective use of bolus insulin in the management of type 2 diabetes mellitus. Medical Sciences, 9(2), 38.

https://doi.org/10.3390/medsci9020038

14. Bolli, G. B., Porcellati, F., Lucidi, P., & Fanelli, C. G. (2021). The physiological basis of insulin therapy in people with diabetes mellitus. Diabetes Research and Clinical Practice, 175, 108839.

https://doi.org/10.1016/j.diabres.2021.108839

15. Bolli, G. B., Home, P. D., Porcellati, F., Riddle, M. C., Gerstein, H. C., Lucidi, P., Fanelli, C. G., & Owens, D. R. (2025). The modern role of basal insulin in advancing therapy in people with type 2 diabetes. Diabetes Care.

https://doi.org/10.2337/dci24-0104

16. Vellanki, P., Cardona, S., Galindo, R. J., Urrutia, M. A., Pasquel, F. J., Davis, G. M., Fayfman, M., Migdal, A., Peng, L., & Umpierrez, G. E. (2022). Efficacy and safety of intensive versus Nonintensive supplemental insulin with a basal-bolus insulin regimen in hospitalized patients with type 2 diabetes: A randomized clinical study. Diabetes Care, 45(10), 2217-2223.

https://doi.org/10.2337/dc21-1606

17. Badia, J. M., Rubio-Pérez, I., López-Menéndez, J., Diez, C., Al-Raies Bolaños, B., Ocaña-Guaita, J., Meijome, X. M., Chamorro-Pons, M., Calderón-Nájera, R., Ortega-Pérez, G., Paredes-Esteban, R., Sánchez-Viguera, C., Vilallonga, R., Picardo, A. L., Bravo-Brañas, E., Espin, E., & Balibrea, J. M. (2020). The persistent breach between evidence and practice in the prevention of surgical site infection. Qualitative study. International Journal of Surgery, 82, 231-239.

https://doi.org/10.1016/j.ijsu.2020.08.027

18. Niyomugabo, A., Mukeshimana, M., Collins, A., & Chironda, G. (2024). Exploring facilitators and barriers to healthcare professionals’ use of clinical guidelines to prevent surgical site infection in Rwandan hospitals. International Journal of Africa Nursing Sciences, 21, 100792.

https://doi.org/10.1016/j.ijans.2024.100792

19. Rosinha, P. M., Inácio, I. M., Teixeira, S. M., Amaral, C. S., & Silva, M. H. (2022). Hyperglycemia in hospitalized patients of a tertiary care hospital: Prevalence and treatment in two cross-sectional evaluations (2011-2020). Archives of Endocrinology and Metabolism.

https://doi.org/10.20945/2359-3997000000452

20. Quigley, M., Zoungas, S., Zimbudzi, E., Wischer, N., Andrikopoulos, S., & Green, S. E. (2022). Making the most of audit and feedback to improve diabetes care: A qualitative study of the perspectives of Australian diabetes centres. BMC Health Services Research, 22(1).

https://doi.org/10.1186/s12913-022-07652-9

21. Ashley-Fenn, W., Janjua, Z., Monir, S., Yaqub, H., Swaray, A., Maltese, G., & Malik, I. (2024). An audit of inpatient insulin prescriptions – how error relates to information source. Future Healthcare Journal, 11(2), 100146.

https://doi.org/10.1016/j.fhj.2024.100146

22. Murphy, W. J., Hand, R. K., Abram, J. K., & Papoutsakis, C. (2021). Impact of diabetes prevention guideline adoption on health outcomes: A pragmatic implementation trial. Journal of the Academy of Nutrition and Dietetics, 121(10), 2090-2100.e1.

https://doi.org/10.1016/j.jand.2020.11.001

23. Nguyen, S., Davis, G. M., & Vasudevan, M. M. (2023). Clinical practice update: Inpatient insulin pump and integrated insulin delivery systems. Contemporary Endocrinology, 95-116.

https://doi.org/10.1007/978-3-031-44648-1_7

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Published

2026-04-29

How to Cite

Abbas, S., Jamil, F., Fatima tu Zuhra, Ahmad, T., Mohmand, I. A., Durrani, M., & Muhammad Shoaib. (2026). Clinical Audit of Inpatient Insulin Prescribing Patterns and Glycemic Outcomes: Sliding Scale Insulin Versus Basal–Bolus Therapy. Indus Journal of Bioscience Research, 4(4), 25-29. https://doi.org/10.70749/ijbr.v4i4.3060