Investigation the Antioxidant Features and Therapeutic Potential of Onion Peel Husk on Elevated Liver Enzymes with Induced Liver Fibrosis in Male Albino Rats
DOI:
https://doi.org/10.70749/ijbr.v3i1.438Keywords:
Phytochemicals, Liver Function EnzymesAbstract
Liver inflammations and fibrosis can be due to liver injury. In liver fibrosis, inflammations which trigger myofibroblasts in the liver release extracellular matrix proteins that produce fibrous scar. There exist a number of plants which are helpful in regulating the malfunctioning of liver enzymes in liver fibrosis. Onion peel contains quercetin which is effective against the management=nt of malfunctioning liver enzymes. 15 albino male subjects were induced with liver fibrosis using carbon tetrachloride injection to investigate their elevated liver function enzymes when given different doses of red onion peel. The serum level of alanine transaminase and aspartate transaminase enzymes were investigated. While members of treatment groups I (T1) and II (T2) received ROP powder in encapsulated quantities of 150 mg and 300 mg per kilogram of body weight, respectively, for 15 days, members of the control group (T0) received no therapy. Onion peel powder can be useful in treating malfunctioning liver enzymes in caused liver fibrosis, as seen by the significant decrease in liver enzymes seen in treatment groups. All results were taken significantly at p<0.05.
Downloads
References
Dibal, N. I., Garba, S. H., & Jacks, T. W. (2022). Onion peel quercetin attenuates ethanol-induced liver injury in mice by preventing oxidative stress and steatosis. Biomedical Research and Therapy, 9(6), 5101-5111. https://doi.org/10.15419/bmrat.v9i6.745
Jiang, Y., Han, X., Dou, J., Yuan, M., Zhou, M., Cui, Z., Lian, L., Nan, J., Zhang, X., & Wu, Y. (2022). Protective role of siberian onions against toxin-induced liver dysfunction: An insight into health-promoting effects. Food & Function, 13(8), 4678-4690. https://doi.org/10.1039/d1fo04404d
Roehlen, N., Crouchet, E., & Baumert, T. F. (2020). Liver fibrosis: Mechanistic concepts and therapeutic perspectives. Cells, 9(4), 875. https://doi.org/10.3390/cells9040875
Dhar, D., Baglieri, J., Kisseleva, T., & Brenner, D. A. (2020). Mechanisms of liver fibrosis and its role in liver cancer. Experimental Biology and Medicine, 245(2), 96-108. https://doi.org/10.1177/1535370219898141
Kisseleva, T., & Brenner, D. (2020). Molecular and cellular mechanisms of liver fibrosis and its regression. Nature Reviews Gastroenterology & Hepatology, 18(3), 151-166. https://doi.org/10.1038/s41575-020-00372-7
El-Beltagi, H. S., Eshak, N. S., Mohamed, H. I., Bendary, E. S., & Danial, A. W. (2022). Physical characteristics, mineral content, and antioxidant and antibacterial activities of punica granatum or citrus sinensis peel extracts and their applications to improve cake quality. Plants, 11(13), 1740. https://doi.org/10.3390/plants11131740
El-Shazly, A. H., Ahmed, N. S., Mohamed, A. Y., Elhossary, G. G., & Elsebaee, F. M. (2017). The Potential Prophylactic Effect of Orange Peel Administration on Fatty Liver and Hyperlipidemia in an Animal Model of Diet Induced Obesity. Cellulose (g), 50, 50.
M’hiri, N., Ioannou, I., Mihoubi Boudhrioua, N., & Ghoul, M. (2015). Effect of different operating conditions on the extraction of phenolic compounds in orange peel. Food and Bioproducts Processing, 96, 161-170. https://doi.org/10.1016/j.fbp.2015.07.010
Touchette, B. W., & Cox, D. S. (2022). Gelatin capsules as a delivery system for tomato (Lycopersicon esculentum) seed enhancements. Seed Science and Technology, 50(3), 367-380. https://doi.org/10.15258/sst.2022.50.3.08
Chhimwal, J., Sharma, S., Kulurkar, P., & Patial, V. (2020). Crocin attenuates CCl4-induced liver fibrosis via PPAR-γ mediated modulation of inflammation and fibrogenesis in rats. Human & Experimental Toxicology, 39(12), 1639-1649. https://doi.org/10.1177/0960327120937048
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Indus Journal of Bioscience Research
This work is licensed under a Creative Commons Attribution 4.0 International License.
