Incidence of Thrombocytopenia in Pregnant Females
DOI:
https://doi.org/10.70749/ijbr.v3i1.489Keywords:
Thrombocytopenia, Ectopic Pregnancy, Gestational Thrombocytopenia, Hypertensive Disorders, PakistanAbstract
Introduction: Thrombocytopenia or low platelet counts are frequent hematologic findings in pregnancy, possibly affecting both the mother and her fetus. This paper aims to establish its prevalence and determinants among pregnant females in the Department of Gynaecology and Obstetrics, District Headquarter Teaching Hospital/ Gomal Medical College, Dera Ismail Khan, Pakistan. Objectives: To assess the frequency, causes, and outcome of thrombocytopenia in pregnant females in a tertiary Health Care teaching Institute. Materials and Methods: The cross-sectional observational study was conducted at Department of Gynaecology and Obstetrics, District Headquarter Teaching Hospital/ Gomal Medical College, Dera Ismail Khan, Pakistan in the duration from June, 2024 to November, 2024. Subjects: this regimen is for pregnant females between 18 and 45 years of age with thrombocytopenia that was documented to be <150,000/μL. Results of platelet counts, clinical assessment, and complications were also recorded and compared. Results: In 250 participants, 62 (24.8%) had thrombocytopenia. The most common cause of thrombocytopenia was Gestational thrombocytopenia (61.3 %), followed by hypertensive disorders (24.2 %) and immune thrombocytopenia (9.7%). It was evident that complications to both the mother and fetus were considerably more severe in moderate and severe forms of the disease. Conclusion: Pathological thrombocytopenia during pregnancy needs early recognition and management to avoid adverse outcomes.
Downloads
References
- Jawad, Z., Umar, B., Janjua, M., Butt, S., & Mushtaq, A. (2021). Incidence of Thrombocytopenia in Pregnant Females Coming to Lady Walingdon Hospital, Lahore. Journal of The Society of Obstetricians and Gynaecologists of Pakistan, 11(2), 135-137. https://jsogp.net/index.php/jsogp/article/view/456
- Qurban, S., Arshad, S., Hussain, S., Imran, S., Munawar, A., & Ashraf, M. N. (2022). Frequency of Thrombocytopenia in pregnant females. Pakistan Journal of Medical and Health Sciences, 16(7), 997-999. https://doi.org/10.53350/pjmhs22167997
- Mozalyova, O. L., Samarina, A. V., & Rassokhin, V. V. (2022). Anemia and thrombocytopenia in HIV-positive pregnant women. Journal of obstetrics and women's diseases, 71(2), 69-78. https://doi.org/10.17816/jowd98476
- Singh, S., Balhara, K., & Oberoi, M. (2021). Prevalence and etiology of Thrombocytopenia in pregnant women in a tertiary care hospital in Delhi. MAMC Journal of Medical Sciences, 7(3), 239-243. https://doi.org/10.4103/mamcjms.mamcjms_52_21
- Erhabor, O., Muhammad, A. D., Adias, T., Ahmed, Y., & Erhabor, T. (2020). Anaemia and thrombocytopenia among pregnant women attending Aminu Kano teaching hospital, Kano state, north western Nigeria. Human Antibodies, 28(1), 11-19. https://doi.org/10.3233/hab-190388
- Bussel, J. B., Cooper, N., Lawrence, T., Michel, M., Vander Haar, E., Wang, K., Wang, H., & Saad, H. (2022). Romiplostim use in pregnant women with immune thrombocytopenia. American Journal of Hematology, 98(1), 31-40. https://doi.org/10.1002/ajh.26743
- Ghafoor, M. B., Sarwar, F., Durrani, T. A., Azher, Z. Q., Jabeen, S., & Ali Khan, M. H. (2023). Pattern of Thrombocytopenia in pregnancy at teaching hospital of Rahim Yar Khan, Pakistan. Journal of Rawalpindi Medical College, 26(4). https://doi.org/10.37939/jrmc.v26i4.2053
- Tarasco, E., Bütikofer, L., Friedman, K. D., George, J. N., Hrachovinova, I., Knöbl, P. N., Matsumoto, M., Von Krogh, A. S., Aebi-Huber, I., Cermakova, Z., Górska-Kosicka, M., Jalowiec, K. A., Largiadèr, C. R., Prohászka, Z., Sinkovits, G., Windyga, J., Lämmle, B., & Kremer Hovinga, J. A. (2021). Annual incidence and severity of acute episodes in hereditary thrombotic thrombocytopenic Purpura. Blood, 137(25), 3563-3575. https://doi.org/10.1182/blood.2020009801
- Reddy, S. B., Sayuktha, L., & Raj, M. R. (2021). Thrombocytopenia in Pregnancy-A Study in Relation to Maternal and Fetal Outcome. http://www.jcmad.com/admin/pdf/934.pdf
- Ghaffar, F., Hanif, A., Nawaz, A., Mahmood, A., Noor, S., & Rizwan, T. (2022). Low platelet count (Thrombocytopenia) in females diagnosed with hypertensive disorder after 20 weeks of gestation. Pakistan Journal of Medical and Health Sciences, 16(10), 658-660. https://doi.org/10.53350/pjmhs221610658
- Thakre, R., Gharde, P., & Raghuwanshi, M. (2023). Idiopathic Thrombocytopenic Purpura: Current limitations and management. Cureus. https://doi.org/10.7759/cureus.49313
- Doobaree, I. U., Conway, K., Miah, H., Miah, A., Makris, M., Hill, Q., Cooper, N., Bradbury, C., Newland, A., Provan, D., & McDonald, V. (2022). Incidence of adult primary immune thrombocytopenia in England—An update. European Journal of Haematology, 109(3), 238-249. https://doi.org/10.1111/ejh.13803
- Sari, Ö., & Üre, Ü. (2022). An evaluation of thrombocytopenia cases in the hematology clinic of the Ankara Numune training and research hospital. The Egyptian Journal of Haematology, 47(1), 35-43. https://doi.org/10.4103/ejh.ejh_56_21
- Payne, A. B., Adamski, A., Abe, K., Reyes, N. L., Richardson, L. C., Hooper, W. C., & Schieve, L. A. (2022). Epidemiology of cerebral venous sinus thrombosis and cerebral venous sinus thrombosis with thrombocytopenia in the United States, 2018 and 2019. Research and Practice in Thrombosis and Haemostasis, 6(2), e12682. https://doi.org/10.1002/rth2.12682
- Nekooghadam, S. M., Ebrahimi‐Dehkordi, S., Paraandavaji, E., Pishgahi, M., Ghadirzadeh, E., Charkazi, E., & Ghorbani, P. (2023). Heparin induced thrombocytopenia in pregnancy: A therapeutic challenge case report and literature review. Clinical Case Reports, 11(8). https://doi.org/10.1002/ccr3.7839
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Indus Journal of Bioscience Research
This work is licensed under a Creative Commons Attribution 4.0 International License.
