Comparison Between IV Lignocaine and IV Labetalol on Hemodynamic Changes during Extubation of Endotracheal Tube

Hira Iqbal; Mohsin Riaz Askri; Shumyala Maqbool; Abida Batool; Noor Ul Ain Yousafi

doi:10.70749/ijbr.v3i4.651

Authors

Hira Iqbal Department of ICU and Anesthesia, Allied Hospital/ Faisalabad Medical University, Faisalabad, Pakistan.
Mohsin Riaz Askri Department of Anesthesia, Children Hospital & Institute of Child Health, Faisalabad, Pakistan.
Shumyala Maqbool Department of Anesthesia Allied Hospital, Faisalabad Medical University, Faisalabad, Pakistan.
Abida Batool Allied Hospital Faisalabad, Pakistan.
Noor Ul Ain Yousafi Children Hospital Faisalabad, Pakistan.

DOI:

https://doi.org/10.70749/ijbr.v3i4.651

Keywords:

Hemodynamic Changes, Laryngoscopy, Lignocaine, Labetalol, Endotracheal Intubation

Abstract

Introduction: Laryngoscopy and endotracheal intubation produce pressor and sympathoadrenal reactions. Certain medications, such as Lignocaine and Labetalol, can be given to prevent these haemodynamic alterations before intubation. Objective: The aim of this study was to compare the hemodynamic changes of IV lignocaine and antihypertensive drug during extubation. Materials and Methods: 60 patients of ASA grade I, scheduled for various surgeries under general anesthesia were divided into 2 Groups. Group A was administered I.V plain lignocaine 1.5 mg/kg. Group B was administered IV labetalol 0.5 mg/kg 2 minutes prior to extubation. HR, SBP, DBP was recorded at baseline and 5 min after tracheal extubation. Results: The mean age of patients was 38.07±11.69 years in the Labetalol group and 34.53±6.68 years in the Lignocaine group. Before induction, hemodynamic parameters were comparable. Pre-induction heart rate (HR) was 85.90±9.51 beats/min in the Labetalol group and 87.40±9.12 beats/min in the Lignocaine group. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were 118.67±11.05 mmHg and 73.87±4.87 mmHg in the Labetalol group, and 122.00±10.30 mmHg and 75.53±4.63 mmHg in the Lignocaine group. Five minutes post-extubation, HR was 90.80±0.99 beats/min in the Labetalol group and 102.50±11.04 beats/min in the Lignocaine group. SBP/DBP were 103.33±7.58 mmHg/71.33±5.76 mmHg in the Labetalol group and 107.67±11.65 mmHg/73.87±5.98 mmHg in the Lignocaine group. These findings align with previous studies, where HR at five minutes post-intubation was significantly lower in the Labetalol group (78.43±6.41 vs. 88.37±6.73 beats/min, p<0.001). Conclusion: Labetalol is a more effective drug in attenuation of hemodynamic response to laryngoscopy and endotracheal intubation in comparison to Lignocaine.

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