Correlation between Glycated Hemoglobin and Syntax Score on Angiography in Patients with Coronary Artery Disease

Authors

  • Muhammad Omer Hashmi Armed Forces Institute of Cardiology & National Institute of Heart Diseases (AFIC-NIHD), Rawalpindi, Pakista
  • Nabil Younas Department of Cardiology, Advanced International Hospital Islamabad, Pakistan
  • Talal Wasif Mirza Department of Cardiology, City Hospital, Gujrat, Pakistan

DOI:

https://doi.org/10.70749/ijbr.v3i4.1906

Abstract

Background: Coronary Syndrome and Myocardial Infraction in people with diabetes. Literature stated that there is very strong relationship exist between HbA1c and syntax score. But different studies showed conflicting results. In order to determine whether the association is strong enough or weak enough in patients belonging to the local community, we want to conduct this study locally. Objective: To determine the correlation between glycated hemoglobin and syntax score on angiography in patients with coronary artery disease. Methodology: This Cross sectional study was conducted at Armed Forces Institute of Cardiology & National Institute of Heart Diseases (AFIC-NIHD), Rawalpindi, Pakistan for the duration of 6 months i.e. August 2024 to January 2025. Total 50 patients from wards who met the eligibility requirements were enrolled. Then blood sample was taken for assessment of HbA1c. All patients underwent angiography and syntax score was noted. This entire data was entered into a proforma. Using SPSS version 21, and Pearson's correlation coefficient was determined. P-values ≤0.05 were considered significant. Results: The mean age of patients was 56.66±8.76 years. There were 29 (58%) males and 21 (42%) females. The mean BMI of patients was 26.83±1.35 kg/m2. Out of 50 patients, 17 (34%) were smokers, 40 (80%) were hypertensive, 46 (92%) were diabetic, 13 (26%) had dyslipidaemia, 9 (18%) had f/h coronary artery disease. The mean duration of coronary artery disease was 9.14±6.32 days. The mean HbA1c of patients was 11.26±2.05 %. The mean syntax score of patients was 17.28±6.73. There was strong positive correlation between HbA1c and syntax score i.e. r = 0.883 (p<0.05). There is a linear relationship exist between HbA1c and syntax score. Conclusion: As a result, there is a significant positive association between syntactic score and HbA1c. We may now use the findings of this study to advocate screening patients for HbA1c levels prior to angiography, anticipate the severity of the disease, and develop treatment plans.

Downloads

Download data is not yet available.

References

1. Shah AD, Langenberg C, Rapsomaniki E, Denaxas S, Pujades-Rodriguez M, Gale CP, et al. Type 2 diabetes and incidence of cardiovascular diseases: a cohort study in 1· 9 million people. The lancet Diabetes & endocrinology. 2015;3(2):105-13.

https://doi.org/10.1016/s2213-8587(14)70219-0

2. Low Wang CC, Hess CN, Hiatt WR, Goldfine AB. Clinical update: cardiovascular disease in diabetes mellitus: atherosclerotic cardiovascular disease and heart failure in type 2 diabetes mellitus–mechanisms, management, and clinical considerations. Circulation. 2016;133(24):2459-502.

https://doi.org/10.1161/circulationaha.116.022194

3. Shah T. Clinical parameters and its association with coronary involvement in diabetic vs. non-diabetic cad patients with reference to syntax score. Interv Cardiol. 2020;12(1):3.

https://doi.org/10.37532/fmic.2020.12(1).643

4. Bharath S, Gosavi S. Angiography findings in diabetic and non-diabetic patients with cardiac symptoms. J Cardiovasc Dis Res. 2020;11(3):60-3.

https://doi.org/10.21276/ijcmr.2019.6.2.15

5. Emara A, Samy NI, Hammad AA. Relationship between glycated haemoglobin and complexity of coronary artery disease in diabetic patients. Journal of Cardiology and Therapy. 2017;5(1):693-6.

https://doi.org/10.17554/j.issn.2309-6861.2018.05.135

6. Srinivasan MP, Kamath PK, Pai ND, Manjrekar PA, Mahabala C. Factors correlating with severity of coronary artery disease in Type 2 diabetic patients on treatment for more than 5 years. British Journal of Medicine and Medical Research. 2014;4(26):4364.

https://doi.org/10.9734/bjmmr/2014/11169

7. Zhang X, Xu X, Jiao X, Wu J, Zhou S, Lv X. The effects of glucose fluctuation on the severity of coronary artery disease in type 2 diabetes mellitus. Journal of diabetes research. 2013;2013.

https://doi.org/10.1155/2013/576916

8. Sarwar N, Aspelund T, Eiriksdottir G, Gobin R, Seshasai SRK, Forouhi NG, et al. Markers of dysglycaemia and risk of coronary heart disease in people without diabetes: Reykjavik prospective study and systematic review. PLoS medicine. 2010;7(5):e1000278.

https://doi.org/10.1371/journal.pmed.1000278

9. Gerstein HC, Swedberg K, Carlsson J, McMurray JJ, Michelson EL, Olofsson B, et al. The hemoglobin A1c level as a progressive risk factor for cardiovascular death, hospitalization for heart failure, or death in patients with chronic heart failure: an analysis of the Candesartan in Heart failure: Assessment of Reduction in Mortality and Morbidity (CHARM) program. Archives of internal medicine. 2008;168(15):1699-704.

https://doi.org/10.2337/dc08-1709

10. Dutta B, Neginhal M, Iqbal F. Glycated hemoglobin (HbA1c) correlation with severity of coronary artery disease in non-diabetic patients-a hospital based study from North-Eastern India. Journal of clinical and diagnostic research: JCDR. 2016;10(9):OC20.

https://doi.org/10.7860/jcdr/2016/22378.8525

11. Karakoyun S, Goekdeniz T, Gürsoy MO, Rencüzoğulları İ, Karabağ Y, Altıntaş B, et al. Increased glycated hemoglobin level is associated with SYNTAX score II in patients with type 2 diabetes mellitus. Angiology. 2016;67(4):384-90.

https://doi.org/10.1177/0003319715591752

12. Habib S, Ullah SZ, Saghir T, Muhammad AS, Deen ZU, Naseeb K, et al. The association between hemoglobin A1c and the severity of coronary artery disease in non-diabetic patients with acute coronary syndrome. Cureus. 2020;12(1).

https://doi.org/10.7759/cureus.6631

13. Mansour MM, Moustafa IM, Ahmed MS, Hblas WR, Ahmed MH, Abd EL AE-HI, et al. Impact of Glycated Haemoglobin Level on Severity of Coronary Artery Disease in Non-Diabetic Patients. The Medical Journal of Cairo University. 2018;86(March):759-67.

https://doi.org/10.21608/mjcu.2018.55559

Downloads

Published

2025-04-30

How to Cite

Hashmi, M. O., Younas, N., & Mirza, T. W. (2025). Correlation between Glycated Hemoglobin and Syntax Score on Angiography in Patients with Coronary Artery Disease. Indus Journal of Bioscience Research, 3(4), 907-910. https://doi.org/10.70749/ijbr.v3i4.1906