Frequency of Intrauterine Death in Primigravida with Meconium Stained Liquor at Term
DOI:
https://doi.org/10.70749/ijbr.v3i4.1932Keywords:
Intrauterine Death, Meconium-stained Liquor, Primigravida, Maternal Age, Socioeconomic StatusAbstract
Background: The intrauterine death remains a major obstetric complication, particularly in primigravida who present with amniotic fluid containing meconium. Identification of concomitant attendant demographic risk factors facilitates selective surveillance as well as early intervention, especially in low-resource hospital settings. Objective: To determine the frequency of intrauterine death in primigravida with meconium stained liquor at term. Study Design: Descriptive cross-sectional study. Duration and Place of Study: The study was conducted from November 2022 to May 2023 at the Department of Obstetrics and Gynaecology, Hayatabad Medical Complex, Peshawar. Methodology: A total of 126 primigravida women aged 18–40 years with singleton pregnancies beyond 36 weeks gestation and meconium-stained liquor on ultrasound were enrolled. Patients with abnormal fetal presentation, congenital anomalies, or maternal comorbidities were excluded. Data were collected prospectively, and fetal outcomes were monitored until delivery. Results: The mean maternal age was 29.83 ± 4.64 years and mean gestational age was 39.37 ± 1.68 weeks. The frequency of intrauterine death was 4.80%. A significant association was found with maternal age (p=0.007) and socioeconomic status (p=0.012), while gestational age showed no significant relationship (p=0.418). Multivariate analysis identified maternal age >30 years as a significant predictor of intrauterine death (OR=0.21, p=0.017). Conclusion: In primigravida women with meconium-stained liquor, maternal age over 30 years significantly increases the risk of intrauterine death.
Downloads
References
1. Gallo, D. M., Romero, R., Bosco, M., Gotsch, F., Jaiman, S., Jung, E., Suksai, M., Ramón y Cajal, C. L., Yoon, B. H., & Chaiworapongsa, T. (2023). Meconium-stained amniotic fluid. American Journal of Obstetrics and Gynecology, 228(5), S1158-S1178.
https://doi.org/10.1016/j.ajog.2022.11.1283
2. Addisu, D., & Mekie, M. (2023). Adverse maternal and perinatal outcomes of meconium?stained amniotic fluid in term labor at hospitals in south Gondar zone, northwest Ethiopia: A prospective cohort study. BioMed Research International, 2023(1).
https://doi.org/10.1155/2023/8725161
3. Lavie, A., Fisch, S., Reicher, L., Zohav, E., & Maslovitz, S. (2023). Correlation of meconium-stained amniotic fluid and adverse pregnancy outcomes between 37 to 39 and 40 to 42 weeks of gestational age. American Journal of Perinatology, 41(S 01), e1591-e1598.
https://doi.org/10.1055/a-2053-8018
4. Zhu, X., Huang, S., Tang, Y., Wu, Z., Sun, Y., Ren, H., Lu, H., Yin, T., Zuo, Q., Ge, Z., & Jiang, Z. (2023). Once we find grade III meconium stained amniotic fluid, must we act as early as possible? International Journal of Women's Health, 15, 7-23.
https://doi.org/10.2147/ijwh.s385356
5. Albalawi, F. D., Faheem, W. A., Thabet, H., & Daghash, H. (2023). Exploring the relationship between childbirth expectations and fear among primigravida women in Saudi Arabia. Cureus.
https://doi.org/10.7759/cureus.49337
6. Bahmaei, H., Mousavi, P., Haghighizadeh, M. H., & Iravani, M. (2023). The impact of maternal position in labor on occiput-posterior position of fetus and pregnancy outcomes in pregnant women without epidural analgesia. Journal of Family & Reproductive Health.
https://doi.org/10.18502/jfrh.v17i2.12871
7. Xin, S., Liu, X., Zheng, J., Lai, H., Zhou, J., Zhang, F., Wu, X., Shen, T., Xu, L., & Zeng, X. (2022). Active management of labor process under smart medical model improves vaginal delivery outcomes of pregnant women with Preeclampsia. Journal of Healthcare Engineering, 2022, 1-7.
https://doi.org/10.1155/2022/8926335
8. Cuenca, D. (2023). Pregnancy loss: Consequences for mental health. Frontiers in Global Women's Health, 3.
https://doi.org/10.3389/fgwh.2022.1032212
9. King, V. J., Bennet, L., Stone, P. R., Clark, A., Gunn, A. J., & Dhillon, S. K. (2022). Fetal growth restriction and stillbirth: Biomarkers for identifying at risk fetuses. Frontiers in Physiology, 13.
https://doi.org/10.3389/fphys.2022.959750
10. Cai, Y., Zhang, X., Wu, X., Liu, H., Qi, L., & Liu, X. (2022). The value of umbilical artery blood gas analysis in the diagnosis and prognosis evaluation of fetal distress. American journal of translational research, 14(7), 4821.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9360831/
11. Leal, C. R., Rezende, K. P., Macedo, E. D., Rezende, G. D., & Corrêa Júnior, M. D. (2023). Comparison between protocols for management of fetal growth restriction. Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics, 45(02), 096-103.
https://doi.org/10.1055/s-0043-1764493
12. Getaneh, Y., Fekadu, E., Jemere, A. T., Mengistu, Z., Tarekegn, G. E., & Oumer, M. (2021). Incidence and determinants of adverse outcomes among women who were managed for eclampsia in the University of Gondar comprehensive specialized hospital, northwest Ethiopia. BMC Pregnancy and Childbirth, 21(1).
https://doi.org/10.1186/s12884-021-04199-1
13. Shekari, M., Jahromi, M. S., Ranjbar, A., Mehrnoush, V., Darsareh, F., & Roozbeh, N. (2022). The incidence and risk factors of meconium amniotic fluid in Singleton pregnancies: An experience of a tertiary hospital in Iran. BMC Pregnancy and Childbirth, 22(1).
https://doi.org/10.1186/s12884-022-05285-8
14. Tolu, L. B., Birara, M., Teshome, T., & Feyissa, G. T. (2020). Perinatal outcome of meconium stained amniotic fluid among labouring mothers at teaching referral hospital in urban Ethiopia. PLOS ONE, 15(11), e0242025.
https://doi.org/10.1371/journal.pone.0242025
15. Shirsath, S. B., Farooqui, A. A., Baria, I. R., & Samreen, M. S. (2023). To Assess Perinatal Outcome in Meconium Stained Amniotic Fluid. Res. J. Med. Sci, 17, 11-15.
16. Shilpasri YM, Madhurya B. (2019). Clinical study of babies born through meconium stained amniotic fluid. Int J Contemp Pediatr, 6(2), 491-496.
http://dx.doi.org/10.18203/2349-3291.ijcp20190687
17. Mahapatra, P, Dash, S, Jena, S, Nanda, S, S, Mahanta, C. (2021). Perinatal outcome of meconium stained amniotic fluid. J Popul Ther Clin Pharmacol. 28(2), 177-181.
http://dx.doi.org/10.53555/jptcp.v28i2.3395
18. Mohammad, N., Jamal, T., Sohaila, A., & Ali, S. R. (2018). Meconium stained liquor and its neonatal outcome. Pakistan Journal of Medical Sciences, 34(6).
https://doi.org/10.12669/pjms.346.15349
19. Ali, L., Anbreen, T., & Yasir, R. (2014). Pregnancies with meconium stained liquor. Journal of Surgery Pakistan (International), 19(1), 3134.
https://www.old.jsp.org.pk/Issues/JSP%2019%20(1)%20Jan-Mar%202014%20PDF/Lubna%20Ali%20OA.pdf
20. Divya, N, V, & Lakshmi, G. V. (2023). Perinatal outcome in meconium stained liquor in labour. IP International Journal of Medical Paediatrics and Oncology, 4(1), 41-46.
https://pdfs.semanticscholar.org/a9f7/8031k7tDhfZMGkbLqBwEkEHwTeKmJWwMT966.pdf
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Indus Journal of Bioscience Research

This work is licensed under a Creative Commons Attribution 4.0 International License.