Maternal Outcomes in Pregnant Women with Uterine Fibroids
DOI:
https://doi.org/10.70749/ijbr.v3i4.2454Keywords:
Anemia, Maternal health, Postpartum hemorrhage, Pregnancy complications, Preterm birth, Uterine fibroids.Abstract
Background: Uterine fibroids are described as benign tumors of the uterine commonly arise in reproductive-age women group. During pregnancy due to hormonal and vascular alterations may produce fibroid enlargement and complications that affect the mother's health. They can be excessive postpartum bleeding, premature labor and anemia and affect the mother's comfort and recovery. Understanding these outcomes in local populations is essential for improving obstetric care, particularly in regions with limited resources and delayed antenatal follow-up. Objective: To determine the maternal outcome in pregnant women with uterine fibroids. Study Design: Cross-sectional study. Duration and Place of Study: This study was conducted from March 2024 to August 2024 in the Department of Obstetrics and Gynecology, Lady Reading Hospital Peshawar. Methodology: Eighty-one pregnant women aged 18–40 years with confirmed uterine fibroids were included through non-probability consecutive sampling. Data were collected using a structured proforma. Postpartum hemorrhage was defined as blood loss greater than 500 milliliters after delivery, preterm delivery as birth before 37 weeks, and anemia as hemoglobin less than 12 grams per deciliter. Results: Postpartum hemorrhage was found in 17.30% of participants, preterm delivery in 9.90%, and anemia in 14.80%. The majority of participants were from middle socioeconomic backgrounds and rural areas. Conclusion: Pregnant women with uterine fibroids are at higher risk of postpartum bleeding, early delivery, and anemia.
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1. Yang Q, Ciebiera M, Bariani MV, Ali M, Elkafas H, Boyer TG, et al. Comprehensive review of uterine fibroids: developmental origin, pathogenesis, and treatment. Endocr Rev. 2022;43(4):678-719.
https://doi.org/10.1210/endrev/bnab039
2. Ali M, Ciebiera M, Vafaei S, Alkhrait S, Chen HY, Chiang YF, et al. Progesterone signaling and uterine fibroid pathogenesis; molecular mechanisms and potential therapeutics. Cells. 2023;12(8):1117.
https://doi.org/10.3390/cells12081117
3. Nozaki Y, Takeuchi S, Arai M, Kuwatsuru Y, Toei H, Okada S, et al. Postoperative symptom changes following uterine artery embolization for uterine fibroid based on FIGO classification. CVIR Endovasc. 2025;8(1):9.
https://doi.org/10.1186/s42155-025-00520-7
4. Tîrnovanu MC, Lozneanu L, Tîrnovanu ŞD, Tîrnovanu VG, Onofriescu M, Ungureanu C, et al. Uterine fibroids and pregnancy: a review of the challenges from a Romanian tertiary level institution. Healthcare (Basel). 2022;10(5):855.
https://doi.org/10.3390/healthcare10050855
5. Don EE, Mijatovic V, Huirne JAF. Infertility in patients with uterine fibroids: a debate about the hypothetical mechanisms. Hum Reprod. 2023;38(11):2045-2054.
https://doi.org/10.1093/humrep/dead194
6. Tabakova N, Sparić R, Tinelli A. Reflections on postpartum hysterectomy as a possible complication of cesarean myomectomy: a long debate. Medicina (Kaunas). 2024;60(4):594.
https://doi.org/10.3390/medicina60040594
7. Arip M, Yap VL, Rajagopal M, Selvaraja M, Dharmendra K, Chinnapan S. Evidence-based management of uterine fibroids with botanical drugs—a review. Front Pharmacol. 2022;13:878407.
https://doi.org/10.3389/fphar.2022.878407
8. Barik A, Singh V, Choudhary A, Yadav P. Central placenta previa with coexisting central cervical fibroid in pregnancy: an obstetrician's nightmare. Cureus. 2021;13(6):e15910.
https://doi.org/10.7759/cureus.15910
9. Kawano M, Okamoto M, Yano M, Kawano Y. Life-threatening anemia due to uterine fibroids: a case series. Exp Ther Med. 2022;24(5):669.
https://doi.org/10.3892/etm.2022.11605
10. Sundermann AC, Aldridge TD, Hartmann KE, Jones SH, Torstenson ES, Edwards DRV. Uterine fibroids and risk of preterm birth by clinical subtypes: a prospective cohort study. BMC Pregnancy Childbirth. 2021;21(1):560.
https://doi.org/10.1186/s12884-021-03968-2
11. Kirschen GW, AlAshqar A, Miyashita-Ishiwata M, Reschke L, El Sabeh M, Borahay MA. Vascular biology of uterine fibroids: connecting fibroids and vascular disorders. Reproduction. 2021;162(2):R1-R18.
https://doi.org/10.1530/REP-21-0087
12. Tancred T, Mubangizi V, Dei EN, Natukunda S, Abankwah DNY, Ellis P, et al. Prevention and management of anaemia in pregnancy: community perceptions and facility readiness in Ghana and Uganda. PLOS Glob Public Health. 2024;4(8):e0003610.
https://doi.org/10.1371/journal.pgph.0003610
13. Sankaran SM, Pillai JS. Fetomaternal outcome in fibroid complicating pregnancy: a retrospective study. Int J Reprod Contracept Obstet Gynaecol. 2021;10(7):2613-20.
14. Kumari V, Gunjan, Sinha R. A clinical study on the impact of uterine fibroids on maternal and fetal outcomes during pregnancy. Int J Pharm Qual Assurance. 2025;16(2):310-315.
15. Al Sulaimani R, Machado L, Al Salmi M. Do large uterine fibroids impact pregnancy? Oman Med J. 2021;36(4):e292.
https://doi.org/10.5001/omj.2021.93
16. Sarwat N, Arshad S, Qurat-ul-Ain, Meo RA. Impact of leiomyoma in pregnancy. J Ayub Med Coll Abbottabad. 2012;24(1):90-92.
17. Chohan FN, Memon S, Abbas S, et al. Uterine leiomyoma and pregnancy outcome: an experience at tertiary care setup. Pak J Med Health Sci. 2021;15(6):1682-1684.
18. Shafique S, Ibrahim N, Akram U, Pervaiz E, Riaz T, Waseem Z. Feto-maternal outcomes in pregnancy with fibroids. J Liaquat Uni Med Health Sci. 2025;
https://doi.org/10.22442/jlumhs.2025.01270
19. Zafar S, Saeed S, Shakeel M, Faiz SA. Evaluate the maternal and fetal outcome in women having pregnancy with fibroids. J Soc Obstet Gynaecol Pak. 2019;9(2):93-96.
20. Sridevi R, Padmavathy B, Soundariaeswari RP. Fibroid complicating pregnancy: maternal and fetal outcome. Int J Acad Med Pharm. 2024;6(3):654-657.
21. Singh D, Masand DL, Gupta B. High-risk pregnancy: fibroids and their impact on maternal and foetal health—insights from a prospective study. Int J Reprod Contracept Obstet Gynecol. 2024;13(12):3616-3619.
22. Usmani SY, Nisa SU, Nisa SS, Latif S. Outcome of pregnancies associated with fibroids. Pak J Med Health Sci. 2013;7(3):748-750.
23. Poovathi M, Ramalingam R. Maternal and fetal outcome in pregnancy with fibroids: a prospective study. Int J Sci Stud. 2016;3(11):169-172.
24. Tabassum S, Saleem M, Bhatti AR, et al. Fetomaternal outcome in pregnant patients with fibroids at a tertiary care hospital. J Popul Ther Clin Pharmacol. 2024;31(9):2915-2921.
https://doi.org/10.53555/jptcp.v31i9.13117
25. Amber S, Fahad A, Maqbool S, Aftab N, Faraz S. Fibroids in pregnancy: a case series. Cureus. 2025;17(7):e87577.
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