Pattern of Clinical Presentations and Risk Factors of Ectopic Pregnancy in Women Presenting to Tertiary Care Hospital
DOI:
https://doi.org/10.70749/ijbr.v3i5.2505Keywords:
Abdominal Pain, Clinical Presentation, Ectopic Pregnancy, Pelvic Infection, Risk Factors, Socioeconomic Status, Vaginal Bleeding.Abstract
Background: Ectopic pregnancy occurs when a fertilized ovum implants outside the uterine cavity, most commonly within the fallopian tube. It remains a serious cause of early maternal morbidity and mortality, especially in developing regions where delayed diagnosis is frequent. Various factors such as infection, previous pelvic surgery, miscarriage, and subfertility can damage the tubes and increase the chance of extra-uterine implantation. Objective: To determine the pattern of clinical presentations and risk factors of ectopic pregnancy in women presenting to tertiary care hospital. Study Design: Cross-sectional descriptive study. Duration and Place of Study: This study was carried out from August 2024 to February 2025 in the Department of Obstetrics and Gynecology, Hayatabad Medical Complex, Peshawar. Methodology: Sixty women aged 18–40 years with confirmed ectopic pregnancy were included. Demographic characteristics, clinical presentations, and predisposing factors were recorded. Data were analyzed for mean, standard deviation, frequency, and percentage using appropriate statistical tests. Results: The mean age was 27.23 ± 4.59 years. Most patients belonged to the lower socioeconomic class (60.0%), were illiterate (80.0%), and lived in rural areas (51.7%). Vaginal bleeding was observed in 28.3%, abdominal pain in 8.3%, and shock in 10.0%, while 53.3% presented without obvious symptoms. The most common risk factor was infection (33.3%), followed by previous surgery (15.0%), subfertility (11.7%), and miscarriage (10.0%). Conclusion: Ectopic pregnancy is more common among young women from low socioeconomic backgrounds. Pelvic infection and surgical history are major contributing factors.
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References
1. Papageorgiou, D., Sapantzoglou, I., Prokopakis, I., & Zachariou, E. (2025). Tubal ectopic pregnancy: From diagnosis to treatment. Biomedicines, 13(6), 1465.
https://doi.org/10.3390/biomedicines13061465
2. Ntafam, C. N., Sanusi-Musa, I., & Harris, R. D. (2024). Intramural ectopic pregnancy: An individual patient data systematic review. European Journal of Obstetrics & Gynecology and Reproductive Biology: X, 21, 100272.
https://doi.org/10.1016/j.eurox.2023.100272
3. Iwe, A. B., Nwafor, J. I., Asiegbu, O. G., Adebayo, J. A., Uche-Nwidagu, B. N., & Ali, V. C. (2021). Spontaneous ruptured bilateral tubal ectopic pregnancy following natural conception. Journal of Human Reproductive Sciences, 14(2), 196-199.
https://doi.org/10.4103/jhrs.jhrs_87_20
4. Kopelman, Z. A., Keyser, E. A., & Morales, K. J. (2021). Ectopic pregnancy until proven otherwise … even with a negative serum hCG test: A case report. Case Reports in Women's Health, 30, e00288.
https://doi.org/10.1016/j.crwh.2021.e00288
5. Rueangket, P., & Rittiluechai, K. (2021). Predictive analytic model for diagnosis of ectopic pregnancy. Frontiers in Medicine, 8.
https://doi.org/10.3389/fmed.2021.646258
6. Thirunavuk Arasoo, V. J., Masalamani, M., Ramadas, A., Dominic, N. A., Liew, D. D., Sia, R. W., Wanigaratne, A., Weerawarna, K., Wong, W. L., & Jeganathan, R. (2022). Association between chlamydial infection with ectopic and full-term pregnancies: A case-control study. Tropical Medicine and Infectious Disease, 7(10), 285.
https://doi.org/10.3390/tropicalmed7100285
7. Ghobrial, S., Ott, J., & Parry, J. P. (2023). An overview of postoperative Intraabdominal adhesions and their role on female infertility: A narrative review. Journal of Clinical Medicine, 12(6), 2263.
https://doi.org/10.3390/jcm12062263
8. Auer-Schmidt, M. M., Rahimi, G., Wahba, A. H., & Schmidt, T. (2021). Hysteroscopic management of intramural ectopic pregnancy. BMJ Case Reports, 14(11), e244514.
https://doi.org/10.1136/bcr-2021-244514
9. Moustakli, E., Domali, E., Potiris, A., Gerede, A., Anagnostaki, I., Zikopoulos, A., Theofanakis, C., Kathopoulis, N., Louis, K., Drakakis, P., & Stavros, S. (2025). After the shock: Impact of ectopic pregnancy on subsequent fertility and parenthood. Biomedicines, 13(9), 2205.
https://doi.org/10.3390/biomedicines13092205
10. Flanagan, H. C., Duncan, W. C., Lin, C., Spears, N., & Horne, A. W. (2023). Recent advances in the understanding of tubal ectopic pregnancy. Faculty Reviews, 12.
https://doi.org/10.12703/r/12-26
11. Thanasa, A., Thanasa, E., Grapsidi, V., Antoniou, I., Gerokostas, E., Kamaretsos, E., Chasiotis, A., & Thanasas, I. (2024). Interstitial ectopic pregnancy associated with painless and severe vaginal bleeding: A rare, atypical clinical presentation. Cureus.
https://doi.org/10.7759/cureus.53225
12. Durden, J. A., Burleson, S. L., Pigott, D. C., Gullett, J. P., & Thompson, M. (2024). Abdominal ectopic pregnancy: A case report of an uncommon complication of pregnancy without prenatal care. Cureus.
https://doi.org/10.7759/cureus.68478
13. Xiao, Z., Long, S., Yan, Z., Chen, Z., Lin, L., & Cao, Y. (2024). A rare case of diaphragmatic rupture due to ectopic pregnancy leading to haemorrhagic shock in a multipara: A case report. International Journal of Women's Health, 16, 1653-1659.
https://doi.org/10.2147/ijwh.s478590
14. Abdelwahid, S. A., Suliman Ibrahim, A. H., Mohammed Adam, H. K., Jaffer Youssef, A. I., Abdalla Elamin, A. M., Omer Elzein, E. A., & Mohamed, I. S. (2023). Ectopic pregnancy risk factors presentation and management outcomes. Clinical Journal of Obstetrics and Gynecology, 6(3), 143-149.
https://doi.org/10.29328/journal.cjog.1001143
15. Gomathi, V., & Praba, K. S. (2022). Study of risk factors, clinical presentation and management of ectopic pregnancy at a rural tertiary care center. Int J Acad Med Pharm, 4(5), 161-165.
https://academicmed.org/Uploads/Volume4Issue5/35.-53.-JAMP_MEDP-161-165.pdf
16. Imran, A., Mustafa, N., & Akhtar, N. (2009). Frequency of different presentations and surgical management of ectopic pregnancy at Combined Military Hospital Lahore. Pakistan Armed Forces Med J, 59(2), 207-10.
17. Kakar, N. S., Salam, R., Bugti, Z., Naz, R., Ehsan, N., & Saifullah, S. (2021). Incidence and presentation of ectopic pregnancy. Med Forum, 32(12), 48-50.
https://medicalforummonthly.com/index.php/mfm/article/view/383
18. Malik, N., Ahmed, T. M., Rauf, M., Aftab, S. B., Ahmed, M. N., & Khan, S. J. (2024). Ectopic pregnancy: An analysis of prevalence and clinical magnitude. Annals of PIMS-Shaheed Zulfiqar Ali Bhutto Medical University, 20(3), 218-221.
https://doi.org/10.48036/apims.v20i3.1081
19. Singh, T., Mohan, S., Aggarwal, S., & Maji, D. (2021). A study on presentation and management of ectopic pregnancy at tertiary care hospital. International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 10(5), 1997.
https://doi.org/10.18203/2320-1770.ijrcog20211526
20. Gauvin, C., Amberger, M., Louie, K., & Argeros, O. (2019). Previously asymptomatic ruptured tubal ectopic pregnancy at over 10 weeks' gestation: Two case reports. Case Reports in Women's Health, 21, e00089.
https://doi.org/10.1016/j.crwh.2018.e00089
21. Rafique, S., e Raana, G., Huma, N., Fatima, A., Ashfaq, M., & Javeed, S. (2015). Analysis of Risk Factors, Impact of Diagnostic Delays on Presentation and Management of Ectopic Pregnancy. Journal of Surgery Pakistan (International), 20, 2.
https://www.old.jsp.org.pk/Issues/JSP%2020%20(2)%20April-June%20PDF%202015/Saima%20Rafique%20OA.pdf
22. Shabab, U., & Hashmi, H. A. (2013). Different pattern of presentation of ectopic pregnancy and its management. Journal of surgery Pakistan (international), 18(1).
https://old.jsp.org.pk/Issues/JSP%2018%20(1)%20Jan%20-%20March%202013%20PDF/Uzma%20Shabab%20OA.pdf
23. Kemal, S., Hussain, R., & Chaudhry, S. (2017). Ectopic Pregnancy–A 3 Year Analysis Of Different Presentations At Tertiary Care Hospitals Of Karachi. Pakistan Journal of Medicine and Dentistry, 6(1), 24-28.
https://ojs.zu.edu.pk/pjmd/article/view/2760
24. John, L. B., Saketha, L. N., & Rathod, S. (2021). Risk factors, clinical presentation and management of ectopic pregnancy in a rural tertiary care centre- An observational study. Indian Journal of Obstetrics and Gynecology Research, 8(3), 296-300.
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