Outcomes of pregnancy in Rhesus Negative Mothers in DHQ Dera Ismail Khan
DOI:
https://doi.org/10.70749/ijbr.v3i5.2719Keywords:
Cesarean section, Fetal distress, Neonatal anemia, Pregnancy outcome, Rh incompatibilityAbstract
Background: Rh negative pregnancy is a major concern in obstetrics, and it has increased risks of complications in mothers and babies. When the mother and father are Rh negative, pregnancy risks in the mother include maternal sensitization, which may cause problems in pregnancy as well as in the baby. The risks are higher in environments with low antenatal care and late booking. Objective: To determine the outcomes of pregnancy in rhesus negative mothers at District Headquarter Hospital Dera Ismail Khan. Study Design: Cross sectional descriptive study. Duration and Place of Study: This study was conducted from August 2023 to February 2024 in the Department of Obstetrics and Gynecology, District Headquarter Hospital, Dera Ismail Khan. Methodology: A total of 252 rhesus negative pregnant women aged 18 to 40 years with singleton pregnancy and gestational age more than 30 weeks were included. Pregnancy outcomes including caesarean section, fetal distress, neonatal anemia and stillbirth were noted. Data were analyzed using Statistical Package for Social Sciences version 26. Chi square test was applied after stratification and p-value ≤ 0.05 was taken as significant. Results: The mean age of participants was 28.83 ± 4.78 years and mean gestational age was 36.77 ± 2.22 weeks. Caesarean section was performed in 59.90% cases, fetal distress was observed in 25.00%, neonatal anemia was found in 9.90% and stillbirth occurred in 5.20% cases. Conclusion: Pregnancy in rhesus negative mothers is associated with high rates of caesarean section and notable adverse fetal outcomes such as fetal distress, neonatal anemia, and stillbirth.
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1. Aliyo A, Ashenafi G, Abduselam M. Rhesus negativity prevalence and neonatal outcomes among pregnant women delivered at Bule Hora University Teaching Hospital, West Guji Zone, South Ethiopia. Clin Med Insights Pediatr. 2023;17:11795565221145598. https://doi.org/10.1177/11795565221145598
2. Pell LG, Ariff S, Khan GN, Dampf H, Jokhio SM, Zipursky A, et al. Point-of-care determination of the frequency of rhesus(D)-negative blood types and the uptake of anti(D) immunoglobulin among Rh(D)-negative women in Dadu district, Sindh, Pakistan. PLOS Glob Public Health. 2025;5(4):e0004395. https://doi.org/10.1371/journal.pgph.0004395
3. Neamţu SD, Novac MB, Neamţu AV, Stanca ID, Boldeanu MV, Gluhovschi A, et al. Fetal-maternal incompatibility in the Rh system: Rh isoimmunization associated with hereditary spherocytosis, case presentation and review of the literature. Rom J Morphol Embryol. 2022;63(1):229-235.
https://doi.org/10.47162/RJME.63.1.26
4. Warner M, Villa N, Winebrenner J, Lewis S, Tjiattas-Saleski L. The complexity of weak rhesus positivity in pregnancy: challenges and management—a case report. Clin Pract Cases Emerg Med. 2025;9(4):436-438.
https://doi.org/10.5811/cpcem.47264
5. Davad D, Majithiya HD, Nagda J. Alloimmunization in a rhesus (Rh) D-negative pregnant woman with an uncommon Rh phenotype: a case report. Cureus. 2025;17(6):e86861. https://doi.org/10.7759/cureus.86861
6. Sun Y, Jiang S. Prenatal monitoring of perinatal pregnant women and fetus based on a smart electronic fetal monitoring system. J Healthc Eng. 2022;2022:5073636.
https://doi.org/10.1155/2022/5073636
Retraction in: J Healthc Eng. 2023;2023:9765425.
https://doi.org/10.1155/2023/9765425
7. Saraswathy V, Subashini M, Jayavani RL, Vaithiyanathan U, Mohan R, Sindhuri R. Predictors of maternal and fetal outcome in severely anemic pregnant mothers: a sequential mixed methods study. J Family Med Prim Care. 2023;12(11):2685-2689. https://doi.org/10.4103/jfmpc.jfmpc_1089_23
8. Dumitru A, Gica N, Botezatu R, Peltecu G. Prognosis and management in subsequent Rh alloimmunized pregnancies. Maedica (Bucur). 2021;16(4):681-684.
https://doi.org/10.26574/maedica.2020.16.4.681
9. Myle AK, Al-Khattabi GH. Hemolytic disease of the newborn: a review of current trends and prospects. Pediatric Health Med Ther. 2021;12:491-498.
https://doi.org/10.2147/PHMT.S327032
10. Júnior MDC, Sosa SEY, Fernandes M, do Carmo L, de Oliveira RW, Kanevsky G. Hemolytic disease of the fetus and newborn and rhesus alloimmunization in Latin American countries: a scoping review. BMC Pregnancy Childbirth. 2024;24(1):830.
https://doi.org/10.1186/s12884-024-07044-3
11. Prezioso G, Perrone S, Biasucci G, Pisi G, Fainardi V, Strisciuglio C, et al. Management of infants with brief resolved unexplained events (BRUE) and apparent life-threatening events (ALTE): a RAND/UCLA appropriateness approach. Life (Basel). 2021;11(2):171.
https://doi.org/10.3390/life11020171
12. Rodrigues JMDSR, Méio MDBB, Santos MCPD, Costa ACCD, Moreira MEL. Use of prophylactic phototherapy for RhD neonatal disease in a referral service. J Pediatr (Rio J). 2023;99(1):53-58. https://doi.org/10.1016/j.jped.2022.04.004
13. Bi BC, Yang HY, Su JY, Deng L. Analysis of pregnancy and neonatal outcomes in 100 pregnant women with Rh-negative blood type. BMC Pregnancy Childbirth. 2024;24(1):815.
https://doi.org/10.1186/s12884-024-06981-3
14. Yadav M, Baral G. Maternal and perinatal outcome in Rh-negative women. Nep J Obstet Gynecol. 2021;16(32):108-110.
https://doi.org/10.3126/njog.v16i1.37619
15. Khalil S, Humayun A, Syed W, Naz N. Fetomaternal complications of Rh-negative blood group. Indus J Biosci Res. 2025;3(6):216-221. https://doi.org/10.70749/ijbr.v3i6.1604
16. Sagar R, Patel S, Dhorajia H, Goswami B. Maternal and foetal outcome in Rh negative pregnancy. Int J Med Pharm Res. 2025;6(4):1264-1267.
17. Puangsricharern A, Suksawat S. Prevalence of Rh-negative pregnant women who attended the antenatal clinic and delivered in Rajavithi Hospital: 2000–2005. J Med Assoc Thai. 2007;90(8):1491-1494.
18. Sharma M, Raigar K, Sisodiya J. Maternal and perinatal outcome in Rh negative mothers. Int J Reprod Contracept Obstet Gynecol. 2023;12(12):3479-3483.
https://doi.org/10.18203/2320-1770.ijrcog20233621
19. Vaishnavi VS, Das P. Study on antenatal and fetal outcomes and complications in rhesus antigen negative pregnancy immunized and unimmunized and measures to prevent adventitious onset. J Popul Ther Clin Pharmacol. 2022;29(4):682-690.
20. Gul K, Bibi S, Gul Z, Gul P. The prevalence of rhesus negative blood group among pregnant women in Bolan Medical Complex Hospital, Quetta. J Soc Obstet Gynaecol Pak. 2016;6(3):98-101.
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