Frequency of Helicobacter Pylori Positive Serology in Patients with Dyspepsia
DOI:
https://doi.org/10.70749/ijbr.v3i5.2780Keywords:
Dyspepsia, Helicobacter pylori, Serology, IgM, Functional Dyspepsia.Abstract
Objective: The purpose of this study is to quantify the number of patients with dyspepsia who test positive for Helicobacter pylori and to identify any correlations between this finding and clinical, risk factor, and lifestyle variables. Study Design: Cross-sectional study. Place and Duration of Study: Department of Medicine, Ittefaq Trust Hospital, Lahore, over a period of six months after approval of the research synopsis. Methodology: The study comprised 130 patients with dyspepsia, aged 16 to 75 years, selected by non-probability sequential selection. Standard clinical criteria were used to define dyspepsia. The following information was documented: demographics, clinical features, comorbidities, lifestyle variables, and the usage of proton pump inhibitors. H. pylori serology was evaluated by collecting venous blood samples and quantifying immunoglobulin M (IgM) levels; results more than 40 U/mL were deemed positive. We used SPSS version 25 to analyses the data. The chi-square test was used to evaluate relationships between factors and H. pylori serology, and descriptive statistics were computed. A p-value <0.05 was considered statistically significant. Results: The participants' average age was 45.39 ± 16.28 years, and slightly more than half of them were female (51.5%). Helicobacter pylori positive serology was found in 18 (13.8%) patients. The majority of patients had dyspeptic symptoms for more than 12 months (66.2%). No statistically significant association was observed between H. pylori seropositivity and age, gender, body mass index, duration of dyspepsia, medical comorbidities, family history, proton pump inhibitor use, lifestyle, or dietary habits (p>0.05). Conclusion: Helicobacter pylori positive serology was detected in a minority of dyspeptic patients, with no significant association with socio-demographic, clinical, or lifestyle factors. These findings support the multifactorial nature of dyspepsia and suggest that H. pylori infection alone may not be a primary determinant of dyspeptic symptoms.
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