Radiographic Findings in Cerebral Palsy Children Presenting to Mardan Medical Complex
DOI:
https://doi.org/10.70749/ijbr.v3i5.2991Keywords:
Brain, Cerebral palsy, Magnetic resonance imaging, Radiography, TomographyAbstract
Background: Cerebral palsy is a permanent disorder of movement and posture caused by non-progressive brain injury. Children with cerebral palsy display different types of neurological problems as well as radiographic abnormalities. However, there is limited information available about radiographic findings in children with cerebral palsy in the Mardan area. Objective: To determine the radiographic findings in children with cerebral palsy presenting to Mardan Medical Complex. Study Design: Cross sectional study. Duration and Place of Study: This study was conducted from 1st September 2024 to 1st March 2025 in Department of Pediatrics, Mardan Medical Complex Mardan. Methodology: Total 106 children aged 1 to 12 years with cerebral palsy were included. Computed tomography and magnetic resonance imaging of brain were performed using standard pediatric neuroimaging protocols. Data was analyzed using Statistical Package for Social Sciences version 26. Quantitative variables were expressed as mean ± standard deviation while categorical variables were presented as frequency and percentage. Results: Mean age of children was 6.96±3.46 years and mean weight was 23.34±7.72 kg. Males were 66 (62.3%) and females were 40 (37.7%). On computed tomography, diffuse brain atrophy was seen in 56 (52.80%), cerebral hypodensities in 48 (45.30%), parenchyma calcifications in 11 (10.40%) and malformations in 8 (7.50%). On magnetic resonance imaging, white matter damage of immaturity was present in 45 (42.50%), basal ganglia damage in 14 (13.20%), cortical subcortical damage in 10 (9.40%) and focal infarct in 8 (7.50%). Conclusion: Radiographic imaging shows important structural brain abnormalities in children with cerebral palsy.
Downloads
References
1. Paul S, Nahar A, Bhagawati M, Kunwar AJ. A review on recent advances of cerebral palsy. Oxid Med Cell Longev. 2022; 2022:2622310.
https://doi.org/10.1155/2022/2622310
2. Basoya S, Kumar S, Wanjari A. Cerebral palsy: a narrative review on childhood disorder. Cureus. 2023;15(11):e49050.
https://doi.org/10.7759/cureus.49050
3. Tegegne KT. Determinants of cerebral palsy in children: systematic review. Sudan J Paediatr. 2023;23(2):126-144.
https://doi.org/10.24911/SJP.106-1670589241
4. Handsfield GG, Williams S, Khuu S, Lichtwark G, Stott NS. Muscle architecture, growth, and biological remodelling in cerebral palsy: a narrative review. BMC Musculoskelet Disord. 2022;23(1):233.
https://doi.org/10.1186/s12891-022-05110-5
5. Horber V, Andersen GL, Arnaud C, De La Cruz J, Dakovic I, Greitane A, et al. Prevalence, clinical features, neuroimaging, and genetic findings in children with ataxic cerebral palsy in Europe. Neurology. 2023;101(24):e2509-e2521.
https://doi.org/10.1212/WNL.0000000000207851
6. Nguefack S, Fongue NN, Tague DAK, Kengne UIM, Tapouh JRM, Nguefack F, et al. Imaging of developmental delay in black African children: a hospital-based study in Yaoundé-Cameroon. Afr Health Sci. 2023;23(1):686-692.
https://doi.org/10.4314/ahs.v23i1.73
7. Russ JB, Agarwal S, Venkatesan C, Scelsa B, Vollmer B, Tarui T, et al. Fetal malformations of cortical development: review and clinical guidance. Brain. 2025;148(6):1888-1903.
https://doi.org/10.1093/brain/awaf094
8. Gafner M, Michelson M, Argilli E, Yosovich K, Sherr EH, Parks KC, et al. Major brain malformations: corpus callosum dysgenesis, agenesis of septum pellucidum and polymicrogyria in patients with BCORL1-related disorders. J Hum Genet. 2022;67(2):95-101.
https://doi.org/10.1038/s10038-021-00971-5
9. Lin J, Zhao X, Qi X, Zhao W, Teng S, Mo T, et al. Structural covariance alterations reveal motor damage in periventricular leukomalacia. Brain Commun. 2024;6(6):fcae405. https://doi.org/10.1093/braincomms/fcae405
10. Mackay MT, Chen J, Shapiro J, Pastore-Wapp M, Slavova N, Grunt S, et al. Association of acute infarct topography with development of cerebral palsy and neurologic impairment in neonates with stroke. Neurology. 2023;101(15):e1509-e1520.
https://doi.org/10.1212/WNL.0000000000207705
11. Velasquez-Minoli JP, Cardona-Ramirez N, Garcia-Arias HF, Restrepo-Restrepo F, Porras-Hurtado GL. Clinical-functional correlation with brain volumetry in severe perinatal asphyxia: a case report. Ital J Pediatr. 2024;50(1):66.
https://doi.org/10.1186/s13052-024-01633-w
12. de Almeida Marcelino AL, Al-Fatly B, Tuncer MS, Krägeloh-Mann I, Koy A, Kühn AA. Lesion distribution and network mapping in dyskinetic cerebral palsy. Brain Commun. 2025;7(3):fcaf228.
https://doi.org/10.1093/braincomms/fcaf228
13. Bax M, Tydeman C, Flodmark O. Clinical and MRI correlates of cerebral palsy: the European cerebral palsy study. JAMA. 2006;296(13):1602-1608.
https://doi.org/10.1001/jama.296.13.1602
14. Sadiq IM, Nooruldeen SA. Brain computerized tomography scans findings in children with cerebral palsy. J Kirkuk Med Coll. 2017;5(1):90-98.
https://doi.org/10.32894/kjms.2021.169447
15. Al-Mosawi AJ. Brain imaging abnormalities in cerebral palsy. J Clin Med Img Case Rep. 2021;1(1):1028.
https://doi.org/10.33309/2639-913x.030202
16. Karim T, Mohammad SS, Dossetor R, Nguyen THG, Trinh QD, Nguyen TVA, et al. Magnetic resonance imaging patterns of children with cerebral palsy: findings from hospital-based surveillance in Vietnam. 2024.
https://doi.org/10.21203/rs.3.rs-4819173/v1
17. Fatima S, Goraya A, Azhar H, Qureshi AA. Evaluation of brain MRI in cerebral palsy patients in the children's hospital Lahore. J Bahria Univ Med Dent Coll. 2024;14(1):40-44.
https://doi.org/10.51985/JBUMDC2023231
18. Towsley K, Shevell MI, Dagenais L. Population-based study of neuroimaging findings in children with cerebral palsy. Eur J Paediatr Neurol. 2011;15(1):29-35.
https://doi.org/10.1016/j.ejpn.2010.07.005
19. Nabi N, Shefa J, Akhter S. Neuro-imaging findings in children with developmental delay and cerebral palsy: experience from a tertiary medical center of Bangladesh. BIRDEM Med J. 2021;11(2):112-115.
https://doi.org/10.3329/birdem.v11i2.53128
20. Sanjee SS, Shettigar CG, Soans ST. Clinical and imaging correlation of cerebral palsy: a retrospective study in a tertiary care centre. Int J Contemp Pediatr. 2019;6(3):1199-1203.
https://doi.org/10.18203/2349-3291.ijcp20192012
21. Manandhar BP, Singh U, Khatun N. Neuroimaging in children with cerebral palsy: a study conducted at tertiary level paediatric hospital of Nepal. J Nepal Paediatr Soc. 2018;38(1):25-30. https://doi.org/10.3126/jnps.v38i1.19330
22. Khadir S, Issa SA. Magnetic resonance imaging findings in patients with cerebral palsy in Duhok, Iraq: case series. J Surg Med. 2020;4(1):1-4.
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Indus Journal of Bioscience Research

This work is licensed under a Creative Commons Attribution 4.0 International License.