Frequency of Abnormal Oral Glucose Tolerance Test in Patients of PCOS with Subfertility
DOI:
https://doi.org/10.70749/ijbr.v3i4.3049Keywords:
Glucose intolerance, Infertility, Insulin resistance, Polycystic ovary syndrome, SubfertilityAbstract
Background: Subfertility is common problem in reproductive age women and polycystic ovarian syndrome is one of major cause of it. Many patients with this condition have disturbance in glucose metabolism due to insulin resistance, which may remain undiagnosed and can affect fertility outcome. Objective: To determine the frequency of abnormal oral glucose tolerance test in patients of polycystic ovarian syndrome with subfertility. Study Design: Cross sectional study. Duration and Place of Study: This study was conducted from 10th June 2024 to 10th December 2024 in Department of Obstetrics and Gynaecology, Lady Reading Hospital Peshawar. Methodology: A total of 120 patients aged 18–40 years with polycystic ovarian syndrome and subfertility were included. Oral glucose tolerance test was performed by giving 75 g glucose and measuring blood glucose after 2 hours. Abnormal test was taken when value was more than 153 mg/dl. Data was analysed using statistical package for social sciences version 26. Results: Mean age was 28.70±5.66 years. Abnormal oral glucose tolerance test was found in 54 (45.00%) patients while 66 (55.00%) were normal. Patients with duration of polycystic ovarian syndrome more than 6 months had higher abnormal results 47 (51.1%) as compared to 7 (25.0%) in ≤6 months (p=0.015). Conclusion: Abnormal oral glucose tolerance test is frequent in patients of polycystic ovarian syndrome with subfertility and longer disease duration shows significant association.
Downloads
References
1. Mínguez-Alarcón L, Williams PL, Souter I, Ford JB, Hauser R, Chavarro JE. Women’s preconception psychological stress and birth outcomes in a fertility clinic: the EARTH study. Front Glob Womens Health. 2024; 5:1293255.
https://doi.org/10.3389/fgwh.2024.1293255
2. Van Den Tweel MM, van den Munckhof EHA, van der Zanden M, Molijn AC, van Lith JMM, Le Cessie S, et al. Bacterial vaginosis in a subfertile population undergoing fertility treatments: a prospective cohort study. J Assist Reprod Genet. 2023;41(2):441-450.
https://doi.org/10.1007/s10815-023-03000-w
3. Skowrońska M, Pawłowski M, Milewski R. A literature review and a proposed classification of the relationships between ovulatory infertility and lifestyle factors based on the three groups of ovulation disorders classified by WHO. J Clin Med. 2023;12(19):6275.
https://doi.org/10.3390/jcm12196275
4. Attia GM, Alharbi OA, Aljohani RM. The impact of irregular menstruation on health: a review of the literature. Cureus. 2023;15(11):e49146. https://doi.org/10.7759/cureus.49146
5. Singh S, Pal N, Shubham S, Sarma DK, Verma V, Marotta F, et al. Polycystic ovary syndrome: etiology, current management, and future therapeutics. J Clin Med. 2023;12(4):1454.
https://doi.org/10.3390/jcm12041454
6. Christ JP, Cedars MI. Current guidelines for diagnosing PCOS. Diagnostics (Basel). 2023;13(6):1113.
https://doi.org/10.3390/diagnostics13061113
7. Ding H, Zhang J, Zhang F, Zhang S, Chen X, Liang W, et al. Resistance to the insulin and elevated level of androgen: a major cause of polycystic ovary syndrome. Front Endocrinol (Lausanne). 2021; 12:741764.
https://doi.org/10.3389/fendo.2021.741764
8. Palomba S, Seminara G, Tomei F, Marino A, Morgante G, Baldini D, et al. Diagnosis and management of infertility in patients with polycystic ovary syndrome (PCOS): guidelines from the Italian society of human reproduction (SIRU) and the Italian centers for the study and conservation of eggs and sperm (CECOS Italy). Reprod Biol Endocrinol. 2025;23:37.
https://doi.org/10.1186/s12958-025-01372-5
9. Agrawal IV A, Dave A, Jaiswal A. Type 2 diabetes mellitus in patients with polycystic ovary syndrome. Cureus. 2023;15(10):e46859.
https://doi.org/10.7759/cureus.46859
10. Herman R, Sikonja J, Jensterle M, Janez A, Dolzan V. Insulin metabolism in polycystic ovary syndrome: secretion, signaling, and clearance. Int J Mol Sci. 2023;24(4):3140.
https://doi.org/10.3390/ijms24043140
11. Smitha C, Sailakshmi OP, Nagaratnamma R. Prevalence of impaired glucose tolerance and diabetes mellitus in women with polycystic ovarian syndrome. J Med Sci. 2017;3(4):116-8.
https://doi.org/10.5005/jp-journals-10045-0070
12. Shamin B, Naseem H, Ahmed EN, Javed H, Mansoor A. Frequency of impaired glucose tolerance in women with polycystic ovarian syndrome. 2025.
https://doi.org/10.65035/pn78p605
13. Lekshmiammal P, Krishnadas S. Hyperinsulinemia in polycystic ovary syndrome. J Med Sci Clin Res. 2017;5(5):21286-21292. https://doi.org/10.18535/jmscr/v5i5.14
14. Zahid S, Sadaf R, Rani N, Ayub M, Wazir N, Qaiser F. Frequency of impaired oral glucose tolerance test results in women with polycystic ovarian syndrome. J Coll Physicians Surg Pak. 2026;36(3):316-319.
https://doi.org/10.29271/jcpsp.2026.03.316
15. Pilla P, Gudi SN. Prevalence of impaired glucose tolerance in nonpregnant polycystic ovarian syndrome patients. J South Asian Fed Obstet Gynecol. 2024.
https://doi.org/10.5005/jp-journals-10006-2409
16. Anwar B, Faiza, Malik S, Qasim M, Fayaz M, Khalid S. Impaired glucose tolerance in patients with polycystic ovarian syndrome. Pak J Med Health Sci. 2023;17(2):589-592.
https://doi.org/10.53350/pjmhs2023172589
17. Krstevska B, Jovanovska Mishevska S, Velkoska Nakova V, Serafimoski V. Prevalence and predictors of impaired glucose tolerance and diabetes mellitus type 2 in patients with polycystic ovary syndrome. Prilozi. 2021;42(2):61-70.
https://doi.org/10.2478/prilozi-2021-0022
18. Mohanapu S, Jeyakumar AM. Prevalence of glucose abnormalities in polycystic ovary syndrome women and evaluating efficacy of fasting blood glucose. Int J Reprod Contracept Obstet Gynecol. 2019;8(5):1751-1756.
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Indus Journal of Bioscience Research
This work is licensed under a Creative Commons Attribution 4.0 International License.
