A Relationship of Bleeding Manifestation with Platelet Counts in Dengue Patients in a Tertiary Care Hospital

Muhammad Jamil; Javeria Iqbal; Hafiz Ahmad Iqrash Qureshi; Ayesha Waheed; Mariyam Rashid; Adeel Ahmed; Muhammad Irfan Jamil

doi:10.70749/ijbr.v3i4.778

Authors

Muhammad Jamil Nishtar Hospital, Multan, Pakistan
Javeria Iqbal Nishtar Hospital, Multan, Pakistan
Hafiz Ahmad Iqrash Qureshi Nishtar Hospital, Multan, Pakistan
Ayesha Waheed Bakhtwar Amin Hospital, Multan, Pakistan
Mariyam Rashid Services Hospital, Lahore, Pakistan
Adeel Ahmed Nishtar Hospital, Multan, Pakistan
Muhammad Irfan Jamil Lahore General Hospital, Lahore, Pakistan

DOI:

https://doi.org/10.70749/ijbr.v3i4.778

Keywords:

Dengue, Thrombocytopenia, Bleeding Manifestations, Platelet Count, Febrile Illness

Abstract

Background and Objective: Dengue fever is a prevalent cause of febrile illness, often associated with thrombocytopenia and bleeding manifestations. The study aims to investigate the relationship between platelet counts and bleeding manifestations among dengue patients admitted to a tertiary care hospital. Material & Methods: A Cross-sectional study was conducted at the Department of Medicine, Nishtar Hospital, Multan, involving 140 confirmed dengue cases with platelet counts below 150,000/µL. This study was conducted over a period of 15 months from July 2023 to September 2024. Patients were categorized by platelet levels and bleeding manifestations and data were analyzed using SPSS version 26. Results: A total of 140 patients with a mean age of 44.23 ± 11.95 years were included in the study. Bleeding manifestations were observed in 57.1% of patients, categorized as single-site bleeding in 36.4% and multiple-site bleeding in 20.7%. Petechiae were the most common manifestation (52.1%), followed by purpura (39.3%) and gum bleeding (37.1%). Severe thrombocytopenia was significantly associated with petechiae (65.6%, p=0.042) and purpura (75.0%, p=0.000), while melena was more frequent in mild thrombocytopenia (35.6%, p=0.000). Hematuria and bleeding gums were significantly correlated with moderate thrombocytopenia (42.9%, p=0.018; 38.1%, p=0.036, respectively). Bleeding status showed no significant trend across platelet count categories (p=0.198). Conclusions: Thrombocytopenia severity is significantly associated with specific bleeding manifestations in dengue patients, highlighting the need for vigilant platelet monitoring to mitigate complications.

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